Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Thao Ung"'
Autor:
Thao Ung, Ronald Robinson, Chrysanthe Spais, Justin Schreiber, Hussein Hallak, Jean Husten, Thelma S. Angeles, Jacquelyn Lyons, Yun Liu
Publikováno v:
Bioanalysis. 13:575-585
Aim: To quantify the free form of a protein as a target-engagement biomarker in nonhuman primate serum, a Meso Scale Discovery ligand-binding assay was developed and qualified. Results: The initial assay produced an unexpected artifact when used to m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15ce1411ff5e30f589db719afc908cd8
https://doi.org/10.4155/bio-2020-0307
https://doi.org/10.4155/bio-2020-0307
Autor:
Keith J. Miller, Kenneth W. Rohrbach, Jianxin Feng, Mary Ann Pelleymounter, Sarah E. Malmstrom, Jinping Gan, Ge Zhang, Ginger Wu, Thao Ung, Chen-Pin Hung, William J. Keim, Karen A. Rossi, Jeffrey A. Robl, Qinling Qu, John M. Fevig, Mary Jane Cullen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:330-335
A series of 2,3,3a,4-tetrahydro-1H-pyrrolo[3,4-c]isoquinolin-5(9bH)-ones is described, several examples of which exhibit potent 5-HT(2C) agonism with excellent selectivity over the closely related 5-HT(2A) and 5-HT(2B) receptors. Compounds such as 38
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2079c57086a886d54141aa8d75f1c8e7
https://doi.org/10.1016/j.bmcl.2012.10.091
https://doi.org/10.1016/j.bmcl.2012.10.091
Autor:
Beverly P. Holskin, Sheryl L. Meyer, Emmanuel Burgeon, Bruce Jones, Thao Ung, Emir Duzic, Sandra Y. Flores, Mark A. Ator, Vincent J. Dupriez
Publikováno v:
Analytical Biochemistry. 400:184-189
Assay technologies that measure intracellular Ca 2+ release are among the predominant methods for evaluation of GPCR function. These measurements have historically been performed using cell-permeable fluorescent dyes, although the use of the recombin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f49fbd3b900603f3b6fc127c513e764
https://doi.org/10.1016/j.ab.2010.01.028
https://doi.org/10.1016/j.ab.2010.01.028
Autor:
Evan B. Janovitz, Mary Ann Pelleymounter, Mary F. Malley, Eva Zuvich, Jeffrey G. Varnes, Xueying Cao, Chen-Pin Hung, Karen A. Rossi, Mary Jane Cullen, Thao Ung, William J. Keim, Sarah E. Malmstrom, Michael Thomas, Keith J. Miller, Ginger Wu, Kenneth W. Rohrbach, Ge Zhang, Rangaraj Narayanan, Qinling Qu, Lois D. Lehman-McKeeman, Jeffrey A. Robl, James Devenny, Dean A. Wacker
Publikováno v:
Journal of Medicinal Chemistry. 50:1365-1379
Robust pharmaceutical treatment of obesity has been limited by the undesirable side-effect profile of currently marketed therapies. This paper describes the synthesis and optimization of a new class of pyrazinoisoindolone-containing, selective 5-HT2C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af9455a4be4dd87363342b50ad98d204
https://doi.org/10.1021/jm0612968
https://doi.org/10.1021/jm0612968
Autor:
Jeffrey A. Robl, Mary Jane Cullen, Guohua Zhao, Mary Ann Pelleymounter, Ginger Wu, Thao Ung, Keith J. Miller, Chet Kwon, Xueying Cao, Chen-Pin Hung, Kenneth W. Rohrbach, Philip D. Stein, Sarah E. Malmstrom, Jinping Gan, Qinling Qu, William J. Keim, Karen A. Rossi, James Devenny, Ge Zhang, Sharon N. Bisaha
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(13)
The 5-HT2C receptor has been implicated as a critical regulator of appetite. Small molecule activation of the 5-HT2C receptor has been shown to affect food intake and regulate body weight gain in rodent models and more recently in human clinical tria
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b37d0ab47b2f6505a7e24bd04d9c9731
https://pubmed.ncbi.nlm.nih.gov/23683593
https://pubmed.ncbi.nlm.nih.gov/23683593
Tricyclic dihydroquinazolinones as novel 5-HT2C selective and orally efficacious anti-obesity agents
Autor:
Chen-Pin Hung, Kenneth W. Rohrbach, Saleem Ahmad, Sarah E. Malmstrom, Thao Ung, Eva O’Tanyi, Mary Jane Cullen, Rangaraj Narayanan, Michael Thomas, Ginger Wu, Keith J. Miller, Jinping Gan, Ge Zhang, William J. Keim, Mary Ann Pelleymounter, Qinling Qu, Jeffrey A. Robl, Khehyong Ngu
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(3)
Agonists of the 5-HT2C receptor have been shown to suppress appetite and reduce body weight in animal models as well as in humans. However, agonism of the related 5-HT2B receptor has been associated with valvular heart disease. Synthesis and biologic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2af6e09eb0fd35884b739a42666bd93a
https://pubmed.ncbi.nlm.nih.gov/20022752
https://pubmed.ncbi.nlm.nih.gov/20022752
Autor:
Dean A. Wacker, Jeffrey G. Varnes, Sarah E. Malmstrom, Xueying Cao, Chen-Pin Hung, Thao Ung, Ginger Wu, Ge Zhang, Eva Zuvich, Michael A. Thomas, William J. Keim, Mary Jane Cullen, Kenneth W. Rohrbach, Qinling Qu, Rangaraj Narayanan, Karen Rossi, Evan Janovitz, Lois Lehman-McKeeman, Mary F. Malley, James Devenny
Publikováno v:
Journal of Medicinal Chemistry; Mar2007, Vol. 50 Issue 6, p1365-1379, 15p