Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Thao T Tang"'
Autor:
Quy Le, Brandon Hadland, Jenny L. Smith, Amanda Leonti, Benjamin J. Huang, Rhonda Ries, Tiffany A. Hylkema, Sommer Castro, Thao T. Tang, Cyd N. McKay, LaKeisha Perkins, Laura Pardo, Jay Sarthy, Amy K. Beckman, Robin Williams, Rhonda Idemmili, Scott Furlan, Takashi Ishida, Lindsey Call, Shivani Srivastava, Anisha M. Loeb, Filippo Milano, Suzan Imren, Shelli M. Morris, Fiona Pakiam, Jim M. Olson, Michael R. Loken, Lisa Brodersen, Stanley R. Riddell, Katherine Tarlock, Irwin D. Bernstein, Keith R. Loeb, Soheil Meshinchi
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 22 (2022)
The CBFA2T3-GLIS2 (C/G) fusion is a product of a cryptic translocation primarily seen in infants and early childhood and is associated with dismal outcome. Here, we demonstrate that the expression of the C/G oncogenic fusion protein promotes the tran
Externí odkaz:
https://doaj.org/article/134ccd270d5242848fcfcd4f706249e4
Autor:
Danielle C. Kirkey, Anisha M. Loeb, Sommer Castro, Cyd Nourigat McKay, LaKeisha Perkins, Laura Pardo, Amanda R. Leonti, Thao T. Tang, Michael R. Loken, Lisa Eidenschink Brodersen, Keith R. Loeb, David A. Scheinberg, Quy Le, Soheil Meshinchi
Publikováno v:
Blood Advances. 7:1178-1189
Preferentially Expressed Antigen in Melanoma (PRAME), a cancer-testis antigen, provides an ideal target for immunotherapy in acute myeloid leukemia (AML). We have shown expression of PRAME in a significant subset of childhood and adult AML and lack o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9d77d911a8410e62c1149667c59de5c
https://doi.org/10.1182/bloodadvances.2022008304
https://doi.org/10.1182/bloodadvances.2022008304
Therapeutic Targeting of Mesothelin with Chimeric Antigen Receptor T Cells in Acute Myeloid Leukemia
Autor:
Katherine Tarlock, Salvatore Fiorenza, Soheil Meshinchi, Lindsey F Call, Quy Le, Cameron J. Turtle, Anisha M Loeb, Cyd Nourigat McKay, Jenny L. Smith, Michael R. Loken, Shivani Srivastava, LaKeisha Perkins, Rhonda E. Ries, Stanley R. Riddell, Amanda R. Leonti, Colin Correnti, Laura Pardo, Thao T. Tang, Tiffany A. Hylkema, Sommer Castro
Publikováno v:
Clinical Cancer Research. 27:5718-5730
Purpose: We previously identified mesothelin (MSLN) as highly expressed in a significant fraction of acute myeloid leukemia (AML) but entirely silent in normal hematopoiesis, providing a promising antigen for immunotherapeutic targeting that avoids h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f065418da887725fff132a03b0ce968c
https://doi.org/10.1158/1078-0432.ccr-21-1546
https://doi.org/10.1158/1078-0432.ccr-21-1546
Autor:
Michael G. Kiflezghi, Sunny Nguyen, Mary Ann K. Li, Socheata Thon, Brian M. Wasko, Yordanos C. Elala, Matt Kaeberlein, Daniel E. L. Promislow, Katherine A. Grayden, Thu H. B. Tran, Mitsuhiro Tsuchiya, Yan Ting Zhao, Irika Sinha, Mitchell B. Lee, Deborah Kim, Karl Rodriguez, Ngoc Han Tran, Daniel T. Carr, Jesse Wang, Tu Anh Nguyen, Thao T Tang, Margarete D. Moore, Priya Ragosti, Priya A. Uppal
Publikováno v:
GeroScience
As the molecular mechanisms of biological aging become better understood, there is growing interest in identifying interventions that target those mechanisms to promote extended health and longevity. The budding yeast Saccharomyces cerevisiae has ser
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ad882866b8140dacf583449b1c91f96
https://doi.org/10.1007/s11357-021-00418-x
https://doi.org/10.1007/s11357-021-00418-x
Autor:
Anilkumar Gopalakrishnapillai, Todd A. Alonzo, Soheil Meshinchi, Min Xu, Steven M. Kornblau, Lisa Broderson, E. Anders Kolb, Timothy J. Triche, Jenny L. Smith, Sonali P. Barwe, Quy Le, Michael R. Loken, Amanda R. Leonti, Colin Correnti, Laura Pardo, Cassie K. Chou, Robert B. Gerbing, Allison Kaeding, Rhonda E. Ries, Katherine Tarlock, Thao T. Tang
Publikováno v:
Blood Adv
In an effort to identify acute myeloid leukemia (AML)-restricted targets for therapeutic development in AML, we analyzed the transcriptomes of 2051 children and young adults with AML and compared the expression profile with normal marrow specimens. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcbabf29991c7fc5db37a55aa3acac84
https://doi.org/10.1182/bloodadvances.2021004424
https://doi.org/10.1182/bloodadvances.2021004424
Autor:
Jay F. Sarthy, Suzan Imren, Brandon Hadland, Soheil Meshinchi, Sommer Castro, Keith R. Loeb, Benjamin J. Huang, Cynthia Nourigat, Scott N. Furlan, LaKeisha Perkins, Shivani Srivastava, Rhonda E. Ries, Thao T Tang, Irwin D. Bernstein, Jenny L. Smith, Lisa Eidenschink Brodersen, Katherine Tarlock, Stanley R. Riddell, Larua Pardo, Lindsey F Call, Amy Beckman, Rhonda Idemmili, Amanda R. Leonti, Tiffany A. Hylkema, Takashi Ishida, Anisha M Loeb, Quy Le, Loken Michael, Robin Williams
Fusion oncoproteins are the initiating event in AML pathogenesis, although they are thought to require additional cooperating mutations for leukemic transformation. CBFA2T3-GLIS2 (C/G) fusion occurs exclusively in infants and is associated with highl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::006f550daf8c2558a104753f1a38f789
https://doi.org/10.21203/rs.3.rs-757279/v1
https://doi.org/10.21203/rs.3.rs-757279/v1
Autor:
Scott R. Kennedy, Alan J. Herr, Thu H. B. Tran, Ian T. Dowsett, Mitchell B. Lee, Niloufar Ghodsian, Anh B. Diep, Michael G. Kiflezghi, Michael S. Chung, Daniel T. Carr, Katherine A. Grayden, Anna Bode, Thao T Tang, Priya A. Uppal, Daniel E. L. Promislow, Ngoc Han Tran, Brian M. Wasko, Sarah G. Stanton, Yordanos C. Elala, Michael Hope, Matt Kaeberlein
Publikováno v:
Proceedings of the National Academy of Sciences. 116:3062-3071
Mutations accumulate within somatic cells and have been proposed to contribute to aging. It is unclear what level of mutation burden may be required to consistently reduce cellular lifespan. Human cancers driven by a mutator phenotype represent an in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a67dbe15949814a4c0c083d887da464
https://doi.org/10.1073/pnas.1815966116
https://doi.org/10.1073/pnas.1815966116
Autor:
Mitchell B. Lee, Michael G. Kiflezghi, Mitsuhiro Tsuchiya, Brian Wasko, Daniel T. Carr, Priya A. Uppal, Katherine A. Grayden, Yordanos C. Elala, Tu Anh Nguyen, Jesse Wang, Priya Rastogi, Sunny Nguyen, Yan Ting Zhao, Deborah Kim, Socheata Thon, Irika Sinha, Thao T. Tang, Ngoc H. B. Tran, Thu H. B. Tran, Margarete D. Moore, Mary Ann K. Li, Karl Rodriguez, Daniel E. L. Promislow, Matt Kaeberlein
Publikováno v:
GeroScience. 44:1889-1889
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc29c3a20f353d796a47d1e09c3e6da0
https://doi.org/10.1007/s11357-022-00544-0
https://doi.org/10.1007/s11357-022-00544-0
Autor:
Quy Le, LaKeisha Perkins, Laura Pardo, Cynthia Nourigat-Mckay, Soheil Meshinchi, Amanda R. Leonti, Lindsey F Call, Thao T. Tang, Sommer Castro
Publikováno v:
Blood. 138:1712-1712
Effective immunotherapy for acute myeloid leukemia (AML) has been limited by the lack of AML-restricted targets (expression in AML but silent in normal hematopoiesis). Current immunotherapies targeting lineage markers CD33 and CD123 (if effective) wo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc5c35230b18e9d1441900e0508e5c9c
https://doi.org/10.1182/blood-2021-153156
https://doi.org/10.1182/blood-2021-153156
Autor:
Amanda R. Leonti, Cynthia Nourigat-Mckay, Rhonda E. Ries, Tiffany A. Hylkema, Sommer Castro, Michael R. Loken, LaKeisha Perkins, Thao T. Tang, Soheil Meshinchi, Lisa Eidenschink Brodersen, Jenny L. Smith, Laura Pardo, Keith R. Loeb, Quy Le
Publikováno v:
Blood. 138:360-360
The CBFA2T3-GLIS2 (CBF/GLIS) fusion is a product of a cryptic translocation exclusively seen in refractory infant AML. Lack of relevant model systems that accurately recapitulate this infant AML has limited progress. To overcome this barrier, we deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27955f1e6f8db810fa370ca1aadd387c
https://doi.org/10.1182/blood-2021-148916
https://doi.org/10.1182/blood-2021-148916