Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Thao Ngoc, Huynh"'
Autor:
Thao Ngoc Huynh, Jody Toperzer, Allison Scherer, Anne Gumina, Tonya Brunetti, Michael K. Mansour, David M. Markovitz, Brian C. Russo
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
The intermediate filament vimentin is present in immune cells and is implicated in proinflammatory immune responses. Whether and how it supports antimicrobial activities of neutrophils are not well established. Here, we developed an immortalized neut
Externí odkaz:
https://doaj.org/article/88eeae99cf5346b9aac4248b852902b5
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Poly(A)-specific ribonuclease (PARN) is a 3′-exoribonuclease that removes poly(A) tails from the 3′ end of RNAs. PARN is known to deadenylate some ncRNAs, including hTR, Y RNAs, and some miRNAs and thereby enhance their stability by limi
Externí odkaz:
https://doaj.org/article/8b9f4079e632425a8c9b274470d90e0f
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Recent studies proposed that m6A modification in mammalian mRNAs increases their recruitment to stress granule. However, here the authors observed that m6A modification has a limited effect on mRNA entry into stress granules.
Externí odkaz:
https://doaj.org/article/dd84e5ce91e34343892c384aea652718
Autor:
Ho-Chang Jeong, Siddharth Shukla, Wilson Chun Fok, Thao Ngoc Huynh, Luis Francisco Zirnberger Batista, Roy Parker
Publikováno v:
Science. 379:901-907
Mutations in the 3′ to 5′ RNA exonuclease USB1 cause hematopoietic failure in poikiloderma with neutropenia (PN). Although USB1 is known to regulate U6 small nuclear RNA maturation, the molecular mechanism underlying PN remains undetermined, as p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74bad78289aa7672d987c70c7d8ff967
https://doi.org/10.1126/science.abj8379
https://doi.org/10.1126/science.abj8379
Autor:
Roubina Tatavosian, Huy Nguyen Duc, Thao Ngoc Huynh, Dong Fang, Benjamin Schmitt, Xiaodong Shi, Yiming Deng, Christopher Phiel, Tingting Yao, Zhiguo Zhang, Haobin Wang, Xiaojun Ren
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Diffuse intrinsic pontine gliomas exhibit a characteristic mutation of lysine 27 to methionine (K27M) in genes encoding histone H3.3. Here the authors show that the H3.3K27M mutation imposes a specific pattern of H3.3K27 methylation by altering the t
Externí odkaz:
https://doaj.org/article/70c84502ebb94488990d301031f7915f
Autor:
Chao Yu Zhen, Roubina Tatavosian, Thao Ngoc Huynh, Huy Nguyen Duc, Raibatak Das, Marko Kokotovic, Jonathan B Grimm, Luke D Lavis, Jun Lee, Frances J Mejia, Yang Li, Tingting Yao, Xiaojun Ren
Publikováno v:
eLife, Vol 5 (2016)
The Polycomb PRC1 plays essential roles in development and disease pathogenesis. Targeting of PRC1 to chromatin is thought to be mediated by the Cbx family proteins (Cbx2/4/6/7/8) binding to histone H3 with a K27me3 modification (H3K27me3). Despite t
Externí odkaz:
https://doaj.org/article/8fc968e384404c7290595ab449b6876e
Autor:
Xiaojun Ren, Chao Yu Zhen, Haobin Wang, Roubina Tatavosian, Kyle Brown, Thao Ngoc Huynh, Brian Ma, Tingting Yao, Samantha Kent, Huy Nguyen Duc
Publikováno v:
Journal of Biological Chemistry. 294:1451-1463
Polycomb group (PcG) proteins repress master regulators of development and differentiation through organization of chromatin structure. Mutation and dysregulation of PcG genes cause developmental defects and cancer. PcG proteins form condensates in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7cf2451c757c64d540ba170ec30ec83
https://doi.org/10.1074/jbc.ra118.006620
https://doi.org/10.1074/jbc.ra118.006620
Publikováno v:
Nature communications. 13(1)
The presence of the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6e43957e8ad230c26fe8a956a3954953
https://pubmed.ncbi.nlm.nih.gov/35768440
https://pubmed.ncbi.nlm.nih.gov/35768440
Publikováno v:
RNA
Stress granules (SGs) are stress-induced RNA–protein assemblies formed from a complex transcriptome of untranslating ribonucleoproteins (RNPs). Although RNAs can be either enriched or depleted from SGs, the rules that dictate RNA partitioning into
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3070a3188adaf1d21b20974c1f1f88da
https://pubmed.ncbi.nlm.nih.gov/33199441
https://pubmed.ncbi.nlm.nih.gov/33199441
Autor:
Jon Demasi, Maria Lai, Graycen Wheeler, Joel Baskin, Michael J. Smallegan, Tom Weiser, Michael Bradshaw, Devin Tauber, Kristen Schneider, Arpan Das, Timothy D. Read, Giulia A Corbet, Thao Ngoc Huynh, Shelby Lennon, John L. Rinn, Kevin Choi, Alison R. Swearingen, Soraya Shehata, Savannah F Spradlin, Matt Hynes-Grace, Daniel Ahrens, Dan Timmons, Benjamin Nebenfuehr
Publikováno v:
PLoS ONE, Vol 16, Iss 6, p e0237055 (2021)
PLoS ONE
PLoS ONE
A key aspect in defining cell state is the complex choreography of DNA binding events in a given cell type, which in turn establishes a cell-specific gene-expression program. Here we wanted to take a deep analysis of DNA binding events and transcript
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01e029000f8dfb90e6ceb791c0fa75ae
https://doi.org/10.1371/journal.pone.0237055
https://doi.org/10.1371/journal.pone.0237055