Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Thao, Perry"'
Autor:
Elfatih Elzein, Cindy Hong Li, Daniel Soohoo, Britton Kenneth Corkey, Chandru Venkataramani, Xiao-Jun Li, Manoj C. Desai, Nesrine El-Bizri, Haibo Jiang, Kobayashi Tetsuya, Nevena Mollova, Sridharan Rajamani, Jason K. Perry, Arvinder Dhalla, Thao Perry, Xiaofen Li, Robert G. Strickley, Notte Gregory, Gerry Rhodes, Ryoko Hirakawa, Luiz Belardinelli, Eve-Irene Lepist, Parkhill Eric Q, Jeff Zablocki, Oliver L. Saunders, Lu Yafan, Rao Kalla, Dmitry Koltun, Cheng Xie, Gongxin Liu, Wei-Qun Wang, Kris M. Kahlig, Bernard P. Murray, Michael Graupe, Guerrero Juan A, Martinez Ruben, Mark Osier, Lufei Hu
Publikováno v:
Journal of Medicinal Chemistry. 59:9005-9017
Late sodium current (late INa) is enhanced during ischemia by reactive oxygen species (ROS) modifying the Nav 1.5 channel, resulting in incomplete inactivation. Compound 4 (GS-6615, eleclazine) a novel, potent, and selective inhibitor of late INa, is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d94b0c7942e17b573ee6f2bc8434003
https://doi.org/10.1021/acs.jmedchem.6b00939
https://doi.org/10.1021/acs.jmedchem.6b00939
Autor:
Elfatih Elzein, Kobayashi Tetsuya, Brian Stafford, Ryoko Hirakawa, Nevena Mollova, Sridharan Rajamani, Belem Avila, Catherine Smith-Maxwell, Thao Perry, Lin Wu, Jennifer Tang, Jeff Zablocki, Xiaofen Li, Wei-Qun Wang, Dmitry Koltun, Parkhill Eric Q, Robert Jiang, Arvinder Dhalla, Luiz Belardinelli
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:3207-3211
We started with a medium throughput screen of heterocyclic compounds without basic amine groups to avoid hERG and β-blocker activity and identified [1,2,4]triazolo[4,3-a]pyridine as an early lead. Optimization of substituents for Late INa current in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98fe40fe24221536f142ea4df6dd02ec
https://doi.org/10.1016/j.bmcl.2016.03.096
https://doi.org/10.1016/j.bmcl.2016.03.096
Autor:
Leanna Lagpacan, Christopher Allen Ziebenhaus, Bruno Marchand, Elfatih Elzein, Jason K. Perry, Bernard P. Murray, Scott Preston Simonovich, Parkhill Eric Q, Armando G. Villaseñor, WaiLok K. Hung, Nikos Pagratis, Rao Kalla, Jeff Zablocki, Dmitry Koltun, John R. Somoza, Timothy R. Hansen, Ron Aoyama, Thao Perry, Magdeleine Hung, Xiaofen Li
Publikováno v:
Bioorganicmedicinal chemistry letters. 28(3)
We hereby disclose the discovery of inhibitors of CaMKII (7h and 7i) that are highly potent in rat ventricular myocytes, selective against hERG and other off-target kinases, while possessing good CaMKII tissue isoform selectivity (cardiac γ/δ vs. n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caba80ce7be1413193b5f5243755c5aa
https://pubmed.ncbi.nlm.nih.gov/29254643
https://pubmed.ncbi.nlm.nih.gov/29254643
Autor:
Jeff A, Zablocki, Elfatih, Elzein, Xiaofen, Li, Dmitry O, Koltun, Eric Q, Parkhill, Tetsuya, Kobayashi, Ruben, Martinez, Britton, Corkey, Haibo, Jiang, Thao, Perry, Rao, Kalla, Gregory T, Notte, Oliver, Saunders, Michael, Graupe, Yafan, Lu, Chandru, Venkataramani, Juan, Guerrero, Jason, Perry, Mark, Osier, Robert, Strickley, Gongxin, Liu, Wei-Qun, Wang, Lufei, Hu, Xiao-Jun, Li, Nesrine, El-Bizri, Ryoko, Hirakawa, Kris, Kahlig, Cheng, Xie, Cindy Hong, Li, Arvinder K, Dhalla, Sridharan, Rajamani, Nevena, Mollova, Daniel, Soohoo, Eve-Irene, Lepist, Bernard, Murray, Gerry, Rhodes, Luiz, Belardinelli, Manoj C, Desai
Publikováno v:
Journal of medicinal chemistry. 59(19)
Late sodium current (late I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::42002de8c78a8f6b8aa2978518cc834f
https://pubmed.ncbi.nlm.nih.gov/27690427
https://pubmed.ncbi.nlm.nih.gov/27690427
Autor:
Xiaofen Li, Rao Kalla, Art Gimbel, Thao Perry, Elfatih Elzein, Jeff Zablocki, Ming Yang, Dewan Zeng
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:1397-1401
A series of N-1 monosubstituted 8-pyrazolyl xanthines have been synthesized and evaluated for their affinity for the adenosine receptors (AdoRs). We have discovered two compounds 18 (CVT-7124) and 28 (CVT-6694) that display good affinity for the A(2B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0ad952cae86b92e38484b3004599916
https://doi.org/10.1016/j.bmcl.2008.01.008
https://doi.org/10.1016/j.bmcl.2008.01.008
Autor:
Venkata Palle, Dewan Zeng, Arthur Gimbel, Xiaofen Li, Thao Perry, Elfatih Elzein, Vaibhav Varkhedkar, Rao Kalla, Jeff Zablocki, Tennig Maa
Publikováno v:
Journal of Medicinal Chemistry. 49:3682-3692
Adenosine has been suggested to induce bronchial hyperresponsiveness in asthmatics, which is believed to be an A(2B) adenosine receptor (AdoR) mediated pathway. We hypothesize that a selective, high-affinity A(2B) AdoR antagonist may provide therapeu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a6bd4f08b2541abc8a8d07048c0e139
https://doi.org/10.1021/jm051268+
https://doi.org/10.1021/jm051268+
Autor:
David Lustig, Elfatih Elzein, Rao Kalla, Xiaofen Li, Dewan Zeng, Art Gimbel, Kwan Leung, Thao Perry, Jeff Zablocki
Publikováno v:
Journal of medicinal chemistry. 51(7)
Recently, we have reported a series of new 1,3-symmetrically (R 1 = R 3) substituted xanthines ( 3 and 4) which have high affinity and selectivity for the human adenosine A 2B receptors (hA(2B)-AdoR). Unfortunately, this class of compounds had poor p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b088faec147c713e7ea581a3e8c1d25c
https://pubmed.ncbi.nlm.nih.gov/18321039
https://pubmed.ncbi.nlm.nih.gov/18321039
Autor:
Rao Kalla, Xiaofen Li, Thao Perry, Mark Micklatcher, Jeff Zablocki, Yuzhi Wu, Tim Marquart, Yuan Li, Elfatih Elzein, Dewan Zeng
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(1)
A series of new selective, high affinity A(1)-AdoR agonists is reported. Compound 23 that incorporated a carboxylic acid functionality in the 4-position of the pyrazole ring displayed K(iL) value of 1 nM for the A(1)-AdoR and5000-fold selectivity ove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f9c92ff65294ce4103cde14d411ffa1
https://pubmed.ncbi.nlm.nih.gov/17045477
https://pubmed.ncbi.nlm.nih.gov/17045477
Autor:
Rao V, Kalla, Elfatih, Elzein, Thao, Perry, Xiaofen, Li, Venkata, Palle, Vaibhav, Varkhedkar, Arthur, Gimbel, Tennig, Maa, Dewan, Zeng, Jeff, Zablocki
Publikováno v:
Journal of medicinal chemistry. 49(12)
Adenosine has been suggested to induce bronchial hyperresponsiveness in asthmatics, which is believed to be an A(2B) adenosine receptor (AdoR) mediated pathway. We hypothesize that a selective, high-affinity A(2B) AdoR antagonist may provide therapeu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f3c11c4c30dcb35bb9abc8cb32f44d6f
https://pubmed.ncbi.nlm.nih.gov/16759111
https://pubmed.ncbi.nlm.nih.gov/16759111
Autor:
Dengming Xiao, Jia Hao, Piscopio Anthony D, Art Gimbel, Thao Perry, Venkata Palle, Jeff Zablocki, Dewan Zeng, Vaibhav Varkhedkar, Kwan Leung, Rao Kalla, Nancy Chu, Tenning Maa
Publikováno v:
Bioorganicmedicinal chemistry letters. 15(3)
Adenosine has been suggested to play a role in asthma, possibly via activation of A2B adenosine receptors on mast cells and other pulmonary cells. We describe our initial efforts to discover a xanthine based selective A2B AdoR antagonist that resulte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34837a4b5b5c01557cb128b940369476
https://pubmed.ncbi.nlm.nih.gov/15664822
https://pubmed.ncbi.nlm.nih.gov/15664822