Zobrazeno 1 - 10
of 1 180
pro vyhledávání: '"Thanos, D"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Human RECQL4, a member of the RecQ helicase family, plays a role in maintaining genomic stability, but its precise function remains unclear. The N-terminus of RECQL4 has similarity to Sld2, a protein required for the firing of DNA replicatio
Externí odkaz:
https://doaj.org/article/80d336316c204714908a6f2c09219e53
Autor:
Rossetti, Giacomo G., Dommann, Noëlle, Karamichali, Angeliki, Dionellis, Vasilis S., Asensio Aldave, Ainhoa, Yarahmadov, Tural, Rodriguez-Carballo, Eddie, Keogh, Adrian, Candinas, Daniel, Stroka, Deborah, Halazonetis, Thanos D.
Publikováno v:
In Cell 31 October 2024 187(22):6220-6234
Autor:
Roberto Ricciardiello, Giulia Forleo, Lina Cipolla, Geraldine van Winckel, Caterina Marconi, Thierry Nouspikel, Thanos D. Halazonetis, Omar Zgheib, Simone Sabbioneda
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract DNA polymerase eta (Polη) is the only translesion synthesis polymerase capable of error-free bypass of UV-induced cyclobutane pyrimidine dimers. A deficiency in Polη function is associated with the human disease Xeroderma pigmentosum varia
Externí odkaz:
https://doaj.org/article/98bb223a95e14e1fac273cbabf508600
Akademický článek
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Autor:
Groelly, Florian J., Dagg, Rebecca A., Petropoulos, Michalis, Rossetti, Giacomo G., Prasad, Birbal, Panagopoulos, Andreas, Paulsen, Teressa, Karamichali, Angeliki, Jones, Samuel E., Ochs, Fena, Dionellis, Vasilis S., Puig Lombardi, Emilia, Miossec, Matthieu J., Lockstone, Helen, Legube, Gaëlle, Blackford, Andrew N., Altmeyer, Matthias, Halazonetis, Thanos D., Tarsounas, Madalena
Publikováno v:
In Molecular Cell 15 September 2022 82(18):3382-3397
Autor:
Bhowmick, Rahul, Lerdrup, Mads, Gadi, Sampath Amitash, Rossetti, Giacomo G., Singh, Manika I., Liu, Ying, Halazonetis, Thanos D., Hickson, Ian D.
Publikováno v:
In Molecular Cell 15 September 2022 82(18):3366-3381
Autor:
Giacomo G. Rossetti, Marianna A. Ossorio, Stephan Rempel, Annika Kratzel, Vasilis S. Dionellis, Samia Barriot, Laurence Tropia, Christoph Gorgulla, Haribabu Arthanari, Volker Thiel, Peter Mohr, Remo Gamboni, Thanos D. Halazonetis
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Mpro, the main protease of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is essential for the viral life cycle. Accordingly, several groups have performed in silico screens to identify Mpro inhibitors that might be used t
Externí odkaz:
https://doaj.org/article/422fbb10202b48f599c596a21a945a4e
Autor:
Florian J. Groelly, Rebecca A. Dagg, Jonathan Mailler, Thanos D. Halazonetis, Madalena Tarsounas
Publikováno v:
STAR Protocols, Vol 4, Iss 1, Pp 101970- (2023)
Summary: Cells experiencing DNA replication stress enter mitosis with under-replicated DNA, which activates a repair mechanism known as mitotic DNA synthesis (MiDAS). Here we describe a protocol to identify at genome wide and at high resolution the g
Externí odkaz:
https://doaj.org/article/474a7216b26e4b8d9a849050a8924633
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2020 Sep 01. 117(36), 21849-21850.
Externí odkaz:
https://www.jstor.org/stable/26969083
A transcription-based mechanism for oncogenic β-catenin-induced lethality in BRCA1/2-deficient cells
Autor:
Rebecca A. Dagg, Gijs Zonderland, Emilia Puig Lombardi, Giacomo G. Rossetti, Florian J. Groelly, Sonia Barroso, Eliana M. C. Tacconi, Benjamin Wright, Helen Lockstone, Andrés Aguilera, Thanos D. Halazonetis, Madalena Tarsounas
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Germline mutations in BRCA1 or BRCA2 tumour suppressor genes predispose to different cancers, as does oncogene activation. Here the authors reveal that aberrant transcription of specific genes triggered by activation of the oncogene β-catenin causes
Externí odkaz:
https://doaj.org/article/df2c21948aa4474d8a16c5c108679eec