Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Thanh C. Ho"'
Autor:
Dimitris Spyridakos, Niki Mastrodimou, Kiran Vemuri, Thanh C. Ho, Spyros P. Nikas, Alexandros Makriyannis, Kyriaki Thermos
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 1, p 240 (2022)
Oxidative stress, neurodegeneration, neuroinflammation, and vascular leakage are believed to play a key role in the early stage of diabetic retinopathy (ESDR). The aim of this study was to investigate the blockade of cannabinoid receptor 1 (CB1R) and
Externí odkaz:
https://doaj.org/article/d0a713dbdfe34183af87614ededd306f
Autor:
Yingpeng Liu, Thanh C. Ho, Mohammed Baradwan, Maria Pascual Lopez-Alberca, Christos Iliopoulos-Tsoutsouvas, Spyros P. Nikas, Alexandros Makriyannis
Publikováno v:
Molecules, Vol 25, Iss 3, p 684 (2020)
A new approach to synthesize cannabilactones using Suzuki cross-coupling reaction followed by one-step demethylation-cyclization is presented. The two key cannabilactone prototypes AM1710 and AM1714 were obtained selectively in high overall yields an
Externí odkaz:
https://doaj.org/article/9155deac76e446faa00a3508784d8783
Autor:
Shakiru O. Alapafuja, Spyros P. Nikas, Thanh C. Ho, Fei Tong, Othman Benchama, Alexandros Makriyannis
Publikováno v:
Molecules, Vol 24, Iss 19, p 3559 (2019)
In earlier work, we reported a novel class of CB2 selective ligands namely cannabilactones. These compounds carry a dimethylheptyl substituent at C3, which is typical for synthetic cannabinoids. In the current study with the focus on the pharmacophor
Externí odkaz:
https://doaj.org/article/b37a6c912e6e42a0961b41d3f816acb9
Autor:
Tia A. Tummino, Christos Iliopoulos-Tsoutsouvas, Joao M. Braz, Evan S. O’Brien, Reed M. Stein, Veronica Craik, Ngan K. Tran, Suthakar Ganapathy, Yuki Shiimura, Fei Tong, Thanh C. Ho, Dmytro S. Radchenko, Yurii S. Moroz, Fangyu Liu, Sian Rodriguez Rosado, Karnika Bhardwaj, Jorge Benitez, Yongfeng Liu, Herthana Kandasamy, Claire Normand, Meriem Semache, Laurent Sabbagh, Isabella Glenn, John J. Irwin, Kaavya Krishna Kumar, Alexandros Makriyannis, Allan I. Basbaum, Brian K. Shoichet
Docking tangible virtual libraries can reveal unexpected chemotypes that complement the structures of biological targets. Seeking new agonists for the cannabinoid-1 receptor (CB1R), we docked 74 million tangible molecules, prioritizing 46 high rankin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f866fdd249e0ce3cd2d9772403b5cafc
https://doi.org/10.1101/2023.02.27.530254
https://doi.org/10.1101/2023.02.27.530254
Publikováno v:
Drug and alcohol dependence. 240
Evidence suggests the existence of a functional interaction between endogenous cannabinoid (CB) and opioid systems. Thus, targeting CB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5dca2d16b05ceaabcaac6f005f27f76c
https://pubmed.ncbi.nlm.nih.gov/36191533
https://pubmed.ncbi.nlm.nih.gov/36191533
Autor:
Thanh C. Ho, Joseph J. Mullins, Marcus A. Tius, Spyros P. Nikas, Ngan K. Tran, Fei Tong, Han Zhou, Nicolai Zvonok, Alexandros Makriyannis
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 72:128836
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9827acce2d791f629f75a0a17137cfe1
https://doi.org/10.1016/j.bmcl.2022.128836
https://doi.org/10.1016/j.bmcl.2022.128836
Publikováno v:
Tetrahedron. 74:4445-4455
The structures of α-lithiated vinyl ethers were explored on the basis of a combined computational and NMR study. Calculations (M06/6-31 + G(d)) on free energies of aggregate formation for a series of α-lithiated vinyl ethers indicated that the tetr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0955b90e3b3cf4a9e4ecccdc420d7e5e
https://doi.org/10.1016/j.tet.2018.07.019
https://doi.org/10.1016/j.tet.2018.07.019
Autor:
Thanh C. Ho, Naoyuki Shimada, Alexandros Makriyannis, Marcus A. Tius, Wen Zhang, Spyros P. Nikas
Publikováno v:
The Journal of Organic Chemistry. 82:7839-7849
We report the design, synthesis, and biological evaluation of a novel class of cannabinergic ligands, namely C1'-azacycloalkyl hexahydrocannabinols. Our synthetic approaches utilize an advanced common chiral intermediate triflate from which all analo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3367235a6f4455066163ebd4e8faaf64
https://doi.org/10.1021/acs.joc.7b00988
https://doi.org/10.1021/acs.joc.7b00988
Autor:
Marcus A. Tius, Thanh C. Ho
Publikováno v:
Cutting-Edge Organic Synthesis and Chemical Biology of Bioactive Molecules ISBN: 9789811362439
A considerable number of cannabinoid compounds have been designed and synthesized since the Mechoulam group reported the first isolation and stereospecific synthesis of natural (−)-Δ9-tetrahydrocannabinol in the 1960s. Following the introduction o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b11a085dc2ccafcce39b2197558540d
https://doi.org/10.1007/978-981-13-6244-6_11
https://doi.org/10.1007/978-981-13-6244-6_11
Autor:
Han Zhou, Ngan K. Tran, Nikolai Zvonok, Spyros P. Nikas, Alexandros Makriyannis, Marcus A. Tius, Fei Tong, Thanh C. Ho
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 38:127882
As a continuation of earlier work on classical cannabinoids bearing bulky side chains we report here the design, synthesis, and biological evaluation of 3′-functionalized oxa-adamantyl cannabinoids as a novel class of cannabinergic ligands. Key syn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45ac64b78f037de7b24e9d003df112b1
https://doi.org/10.1016/j.bmcl.2021.127882
https://doi.org/10.1016/j.bmcl.2021.127882