Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Thangaraj Sindhu"'
Autor:
Poopandi, Saritha, Sundaraj, Rajamanikandan, Rajmichael, Raji, Thangaraj, Sindhu, Dhamodharan, Prabhu, Biswal, Jayashree, Malaisamy, Veerapandiyan, Jeyaraj Pandian, Chitra, Jeyaraman, Jeyakanthan *
Publikováno v:
In Molecular & Biochemical Parasitology November 2021 246
QcrB is an essential subunit of cytochrome-bc1 complex and is anticipated as a therapeutic target for tuberculosis. In recent years, significant attempts have been made to develop different chemical classes of QcrB inhibitors. Among them, a series of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efb0b7fd19d4dd07471b53e1e30d2925
https://doi.org/10.21203/rs.3.rs-2903522/v1
https://doi.org/10.21203/rs.3.rs-2903522/v1
Autor:
Thangaraj Sindhu, Pal Debnath
Publikováno v:
Current Molecular Pharmacology. 15:380-392
The cytochrome bc1-aa3 supercomplex plays an essential role in the cellular respiratory system of Mycobacterium Tuberculosis. It transfers electrons from menaquinol to cytochrome aa3 (Complex IV) via cytochrome bc1 (Complex III), which reduces the ox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c13f7183e6bd7565fa6421491f0a9f83
https://doi.org/10.2174/1874467214666210928152512
https://doi.org/10.2174/1874467214666210928152512
Publikováno v:
Journal of Molecular Graphics and Modelling. 118:108347
Cytochrome b (QcrB) is considered an essential subunit in the electron transport chain that coordinates the action of the entire cytochrome bc1 oxidase. It has been identified as an attractive drug target for a new promising clinical candidate Q203 t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59246faa64f36d2ced1333da3c82c6cb
https://doi.org/10.1016/j.jmgm.2022.108347
https://doi.org/10.1016/j.jmgm.2022.108347
Publikováno v:
Biochemical Engineering Journal. 121:59-72
Insect Ryanodine receptor (RyR) is an intracellular calcium release channels that play a key role in calcium signaling in numerous cell types. Targeting Ryanodine receptor is considered as efficient treatment option for the control of diamondback mot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::936cfe04f46c9e2b9b6dc8a4b9d47f7a
https://doi.org/10.1016/j.bej.2017.01.013
https://doi.org/10.1016/j.bej.2017.01.013
Autor:
Pappu Srinivasan, Thangaraj Sindhu
Publikováno v:
Journal of Receptors and Signal Transduction. 37:109-123
Takeda G-protein-coupled receptor 5 (TGR5) is emerging as an important and promising target for the development of anti-diabetic drugs. Pharmacophore modeling and atom-based 3D-QSAR studies were carried out on a new series of 5-phenoxy-1,3-dimethyl-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05f82fd9e0addb46730a196261bef07b
https://doi.org/10.1080/10799893.2016.1189564
https://doi.org/10.1080/10799893.2016.1189564
Autor:
S. K. Jalali, Thiruvengadam Venkatesan, Jeyaraman Jeyakanthan, Thangaraj Sindhu, Dhamodharan Prabhu, Gandhi R. Gracy, Anil Rai
Publikováno v:
Computational biology and chemistry. 77
Acetylcholinesterase-1 (AChE1) is a vital enzyme involved in neurotransmission and represents an attractive insecticide-target for organophosphates and carbamates in Plutella xylostella (Linneaus), an important pest of cruciferous crops worldwide. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9e8a8359ca24dc1c3134ddb549b0bd0
https://pubmed.ncbi.nlm.nih.gov/30368112
https://pubmed.ncbi.nlm.nih.gov/30368112
Autor:
Thangaraj Sindhu, Pappu Srinivasan
Publikováno v:
Molecular BioSystems. 11:1305-1318
Farnesoid X receptor and Takeda G-protein-coupled receptor-5 are well known bile acid receptors and act as promising targets for the drug development and treatment of diabetes. Agonists of both the bile acid receptors increase insulin sensitivity and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05e2d2f75fc3d6eab565ca6973a8a1bb
https://doi.org/10.1039/c5mb00137d
https://doi.org/10.1039/c5mb00137d
Autor:
Pappu Srinivasan, Thangaraj Sindhu
Publikováno v:
RSC Advances. 5:14202-14213
TGR5, a G-protein coupled receptor, acts as a promising target for the treatment of diabetes, obesity and metabolic syndromes. Understanding the activation of TGR5, the structural conformation and the mode of mechanism upon binding with agonists is c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8794da7af5cb1a0e73c68c83ca408396
https://doi.org/10.1039/c4ra16617e
https://doi.org/10.1039/c4ra16617e
Autor:
Paramasivam Ragavendran, Velliyur Kanniappan Gopalakrishnan, Dhanapal Durgapriya, Dominic Sophia, Thangaraj Sindhu, Sundaraj Rajamanikandan
Publikováno v:
Asian Pacific Journal of Tropical Medicine. 5:862-867
ObjectiveTo evaluate the protective effect of ethanol extract of Mollugo nudicaulis (M. nudicaulis) against perchloroethylene-induced hepatotoxicity.MethodsThe hepatoprotective activity of the ethanol extract of M. nudicaulis (200 mg/kg body wt) was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90fe2f8d6c0571fecf9381065595e955
https://doi.org/10.1016/s1995-7645(12)60161-8
https://doi.org/10.1016/s1995-7645(12)60161-8