Zobrazeno 1 - 10
of 170
pro vyhledávání: '"Thangamani Muthukumar"'
Autor:
Thalia Salinas, Carol Li, Catherine Snopkowski, Gabriel Stryjniak, Shady Albakry, Ruchuang Ding, Steven P. Salvatore, Surya V. Seshan, Darshana M. Dadhania, Thangamani Muthukumar, Manikkam Suthanthiran
Publikováno v:
Journal of Clinical and Translational Science, Vol 8, Pp 140-140 (2024)
OBJECTIVES/GOALS: RNA-seq of urine and kidney allograft biopsies (bx) found that urinary cell immune landscape reflects intragraft molecular events and we discovered a shared set of 127 mRNAs in urine matched to T cell mediated and antibody mediated
Externí odkaz:
https://doaj.org/article/554c8329fe1a417a8fb55555066a71f0
Autor:
Ayman Al Jurdi, Esther C. Liu, Thalia Salinas, Meredith J. Aull, Michelle Lubetzky, Alexander L. Drelick, Catherine B. Small, Sandip Kapur, Choli Hartono, Thangamani Muthukumar
Publikováno v:
Frontiers in Nephrology, Vol 2 (2022)
BackgroundKidney transplantation in HIV-infected individuals with end-stage kidney disease is associated with improved survival compared to dialysis. Rabbit anti-thymocyte globulin (rATG) induction in HIV-infected kidney transplant recipients has bee
Externí odkaz:
https://doaj.org/article/efc10ce84b32427c909a32c2178761a4
Autor:
Thalia Salinas, Carol Li, Catherine Snopkowski, Gabriel Stryjniak, Divya Shankaranarayanan, Shady Albakry, Ruchuang Ding, Vijay K. Sharma, Steven P. Salvatore, Surya V. Seshan, Darshana M. Dadhania, Thangamani Muthukumar, Manikkam Suthanthiran
Publikováno v:
Journal of Clinical and Translational Science, Vol 7, Pp 95-96 (2023)
OBJECTIVES/GOALS: Development of a user friendly home kit that enables kidney transplant recipients to process urine at home and post the lysate containing RNA to a Core Laboratory would simplify urinary cell mRNA profiling and facilitate longitudina
Externí odkaz:
https://doaj.org/article/82a2230afcfa4ac08214587af5968636
Autor:
Sami Alasfar, Isaac E. Hall, Sherry G. Mansour, Yaqi Jia, Heather R. Thiessen-Philbrook, Francis L. Weng, Pooja Singh, Bernd Schröppel, Thangamani Muthukumar, Sumit Mohan, Rubab F. Malik, Meera N. Harhay, Mona D. Doshi, Enver Akalin, Jonathan S. Bromberg, Daniel C. Brennan, Peter P. Reese, Chirag R. Parikh
Publikováno v:
BMC Nephrology, Vol 22, Iss 1, Pp 1-10 (2021)
Abstract Background Post-Transplant erythrocytosis (PTE) has not been studied in large recent cohorts. In this study, we evaluated the incidence, risk factors, and outcome of PTE with current transplant practices using the present World Health Organi
Externí odkaz:
https://doaj.org/article/1fd8b64bfaf34fd0aa61c904343483b8
Autor:
Sherry G. Mansour, Nadeen Khoury, Ravi Kodali, Sarthak Virmani, Peter P. Reese, Isaac E. Hall, Yaqi Jia, Yu Yamamoto, Heather R. Thiessen-Philbrook, Wassim Obeid, Mona D. Doshi, Enver Akalin, Jonathan S. Bromberg, Meera N. Harhay, Sumit Mohan, Thangamani Muthukumar, Pooja Singh, Francis L. Weng, Dennis G. Moledina, Jason H. Greenberg, Francis P. Wilson, Chirag R. Parikh
Publikováno v:
PLoS ONE, Vol 17, Iss 3 (2022)
Background Acute kidney injury (AKI) in deceased donors is not associated with graft failure (GF). We hypothesize that hemodynamic AKI (hAKI) comprises the majority of donor AKI and may explain this lack of association. Methods In this ancillary anal
Externí odkaz:
https://doaj.org/article/ceba8cc55e9944ea9b6c83c9613ca2d9
Autor:
Hemant Suryawanshi, Hua Yang, Michelle Lubetzky, Pavel Morozov, Mila Lagman, Gaurav Thareja, Alicia Alonso, Carol Li, Catherine Snopkowski, Aziz Belkadi, Franco B. Mueller, John R. Lee, Darshana M. Dadhania, Steven P. Salvatore, Surya V. Seshan, Vijay K. Sharma, Karsten Suhre, Manikkam Suthanthiran, Thomas Tuschl, Thangamani Muthukumar
Publikováno v:
PLoS ONE, Vol 17, Iss 6 (2022)
We tested the hypothesis that single-cell RNA-sequencing (scRNA-seq) analysis of human kidney allograft biopsies will reveal distinct cell types and states and yield insights to decipher the complex heterogeneity of alloimmune injury. We selected 3 b
Externí odkaz:
https://doaj.org/article/83187766d5604e109b43277b65fa3517
Autor:
David M. Barry, Elizabeth A. McMillan, Balvir Kunar, Raphael Lis, Tuo Zhang, Tyler Lu, Edward Daniel, Masataka Yokoyama, Jesus M. Gomez-Salinero, Angara Sureshbabu, Ondine Cleaver, Annarita Di Lorenzo, Mary E. Choi, Jenny Xiang, David Redmond, Sina Y. Rabbany, Thangamani Muthukumar, Shahin Rafii
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The kidney is vascularized with highly specialized and zonated endothelial cells that are essential for its filtration function. Here, Barry et al. provide a single-cell RNA sequencing analysis of the kidney vasculature that highlights its transcript
Externí odkaz:
https://doaj.org/article/89ca827692df403aa71f8398b5ac7748
Autor:
Aziz Belkadi, Gaurav Thareja, Darshana Dadhania, John R Lee, Thangamani Muthukumar, Catherine Snopkowski, Carol Li, Anna Halama, Sara Abdelkader, Silvana Abdulla, Yasmin Mahmoud, Joel Malek, Manikkam Suthanthiran, Karsten Suhre
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0249930 (2021)
Kidney transplantation is the treatment of choice for patients with end-stage kidney failure, but transplanted allograft could be affected by viral and bacterial infections and by immune rejection. The standard test for the diagnosis of acute patholo
Externí odkaz:
https://doaj.org/article/e3b8bfb0e4b34eb7953fbe033bbfc53c
Autor:
Bryan J. Dooley, MD, Akanksha Verma, BA, Ruchuang Ding, MD, Hua Yang, MD, Thangamani Muthukumar, MD, Michele Lubetzky, MD, Divya Shankaranarayanan, MD, Olivier Elemento, PhD, Manikkam Suthanthiran, MD
Publikováno v:
Transplantation Direct, Vol 6, Iss 8, p e588 (2020)
Background. Identification of a shared gene expression pattern between T cell–mediated rejection (TCMR) and antibody-mediated rejection (AMR) in human kidney allografts may help prioritize targets for the treatment of both types of acute rejection.
Externí odkaz:
https://doaj.org/article/e31b37e4a46c43e9948ec9a272da5afe
Autor:
Choli Hartono, Miriam Chung, Alan S. Perlman, James M. Chevalier, David Serur, Surya V. Seshan, Thangamani Muthukumar
Publikováno v:
Kidney International Reports, Vol 3, Iss 4, Pp 861-866 (2018)
Introduction: IgA nephropathy is the most common glomerulonephritis in the world. We conducted a pilot trial (NCT01103778) to test the effect of bortezomib in patients with IgA nephropathy and significant proteinuria. Methods: We treated 8 consecutiv
Externí odkaz:
https://doaj.org/article/558a1cc0a4764eefb7d51aca0c332595