The LetA/S two-component system regulates transcriptomic changes that are essential for the culturability of Legionella pneumophila in water

Autor: Nilmini Mendis, Peter McBride, Joseph Saoud, Thangadurai Mani, Sebastien P. Faucher

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-17 (2018)

Abstract Surviving the nutrient-poor aquatic environment for extended periods of time is important for the transmission of various water-borne pathogens, including Legionella pneumophila (Lp). Previous work concluded that the stringent response and t

Externí odkaz: https://doaj.org/article/041ada4e1a704882b6a2c60f3dd375e8

Polymorphism in ion channel genes of Dirofilaria immitis: Relevant knowledge for future anthelmintic drug design

Autor: Thangadurai Mani, Catherine Bourguinat, Kathy Keller, Elena Carreton, Andrew Peregrine, Roger K. Prichard

Publikováno v: International Journal for Parasitology: Drugs and Drug Resistance, Vol 6, Iss 3, Pp 343-355 (2016)

Dirofilaria immitis, a filarial parasite, causes cardiopulmonary dirofilariasis in dogs, cats and wild canids. The macrocyclic lactone (ML) class of drugs has been used to prevent heartworm infection. There is confirmed ML resistance in D. immitis an

Externí odkaz: https://doaj.org/article/7378510947f5421c8c7efc078d01a33d

A tail-specific protease is required for Legionella pneumophila intracellular multiplication

Autor: Joseph Saoud, Thangadurai Mani, Petra Rohrbach, Sébastien P. Faucher

Publikováno v: Canadian Journal of Microbiology. 68:747-757

Legionella pneumophila is a Gram-negative bacterium found in natural and man-made water systems where it replicates within amoebas and ciliates. In humans, once inside the lungs, L. pneumophila replicates in alveolar macrophages and causes Legionnair

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::22131fcca27eaf23352db759bfc2a081
https://doi.org/10.1139/cjm-2022-0119

Polymorphism in ABC transporter genes of Dirofilaria immitis

Autor: Roger K. Prichard, Catherine Bourguinat, Thangadurai Mani

Publikováno v: International Journal for Parasitology: Drugs and Drug Resistance, Vol 7, Iss 2, Pp 227-235 (2017)
International Journal for Parasitology: Drugs and Drug Resistance

Dirofilaria immitis, a filarial nematode, causes dirofilariasis in dogs, cats and occasionally in humans. Prevention of the disease has been mainly by monthly use of the macrocyclic lactone (ML) endectocides during the mosquito transmission season. R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7af325a1585ac782d1426e182bedfad2
http://www.sciencedirect.com/science/article/pii/S2211320717300143

Interaction of macrocyclic lactones with a Dirofilaria immitis P-glycoprotein

Autor: Byron L. Blagburn, Shoaib Ashraf, Catherine Bourguinat, Roger K. Prichard, Thangadurai Mani, Kathy Keller

Publikováno v: International Journal for Parasitology. 46:631-640

Dirofilaria immitis, a filarial nematode, causes dirofilariasis or heartworm disease in dogs, cats and wild canids. Effective prevention of the disease is mainly by the use of the macrocyclic lactone class of drugs as heartworm preventives, and no ot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d717e6cffaa6ebaddf9d1a1d327f45e
https://doi.org/10.1016/j.ijpara.2016.04.004