Výsledky vyhledávání - "Thang Kien Chiu"

Testing water-mediated DNA recognition by the Hin recombinase

Autor: Thang Kien Chiu, Reid C. Johnson, Richard E. Dickerson, Catherine S. Sohn

Publikováno v: The EMBO Journal. 21:801-814

The Hin recombinase specifically recognizes its DNA-binding site by means of both major and minor groove interactions. A previous X-ray structure, together with new structures of the Hin DNA-binding domain bound to a recombination half-site that were

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https://doi.org/10.1093/emboj/21.4.801

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Intrinsic bending and deformability at the T-A step of CCTTTAAAGG: A comparative analysis of T-A and A-T steps within A-tracts11Edited by I. Tinoco

Autor: Darcy R. Mack, Thang Kien Chiu, Richard E. Dickerson

Publikováno v: Journal of Molecular Biology. 312:1037-1049

Introduction of a T-A or pyrimidine-purine step into a straight and rigid A-tract can cause a positive roll deformation that kinks the DNA helix at that step. In CCTTTAAAGG, the central T-A step has an 8.6° bend toward the major groove. We report th

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https://doi.org/10.1006/jmbi.2001.4994

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1 Å crystal structures of B -DNA reveal sequence-specific binding and groove-specific bending of DNA by magnesium and calcium 1 1Edited by I. Tinoco

Autor: Richard E. Dickerson, Thang Kien Chiu

Publikováno v: Journal of Molecular Biology. 301:915-945

The 1 A resolution X-ray crystal structures of Mg(2+) and Ca(2+) salts of the B-DNA decamers CCAACGTTGG and CCAGCGCTGG reveal sequence-specific binding of Mg(2+) and Ca(2+) to the major and minor grooves of DNA, as well as non-specific binding to bac

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https://doi.org/10.1006/jmbi.2000.4012

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Absence of Minor Groove Monovalent Cations in the Crosslinked Dodecamer C-G-C-G-A-A-T-T-C-G-C-G

Autor: Maria Kaczor-Grzeskowiak, Thang Kien Chiu, Richard E. Dickerson

Publikováno v: Journal of Molecular Biology. 292:589-608

The structure of a crosslinked B -DNA dodecamer of sequence C-G-C-G-A-A-T-T-C-G-C-G has been solved to a resolution of 1.43 A. The dithiobis-propane crosslink, -CH2-CH2-CH2-S-S-CH2-CH2-CH2-, bridges N7 atoms of adenine bases 6 and 18 in the two centr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::035b9d29bab1d93cddd20e090b7a91ef
https://doi.org/10.1006/jmbi.1999.3075

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Helix bending as a factor in protein/DNA recognition

Autor: Thang Kien Chiu, Richard E. Dickerson

Publikováno v: Biopolymers. 44:361-403

Normal vectors perpendicular to individual base pairs are a powerful tool for studying the bending behavior of B-DNA, both in the form of normal vector plots and in matrices that list angles between vectors for all possible base pair combinations. A

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https://doi.org/10.1002/(sici)1097-0282(1997)44:4<361::aid-bip4>3.0.co

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1 Å crystal Structures of B-DNA reveal sequence-specific binding and groove-specific bending of DNA by magnesium and calcium

Autor: Thang Kien Chiu, Richard E. Dickerson

Publikováno v: Journal of Molecular Biology. 303:111

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https://doi.org/10.1006/jmbi.2000.4144

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Defining GC-specificity in the minor groove: side-by-side binding of the di-imidazole lexitropsin to C-A-T-G-G-C-C-A-T-G

Autor: J.W. Lown, Mary L. Kopka, Thang Kien Chiu, David S. Goodsell, Richard E. Dickerson, Gye Won Han

Publikováno v: Structure. (8):1033-1046

Background: Polyamide drugs, such as netropsin, distamycin and their lexitropsin derivatives, can be inserted into a narrow B-DNA minor groove to form 1:1 complexes that can distinguish AT base pairs from GC, but cannot detect end-for-end base-pair r

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