Exome sequencing identifies novel somatic variants in African American esophageal squamous cell carcinoma

Autor: Hayriye Verda Erkizan, Shrey Sukhadia, Thanemozhi G. Natarajan, Gustavo Marino, Vicente Notario, Jack H. Lichy, Robert G. Wadleigh

Publikováno v: Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)

Abstract Esophageal cancer has a strikingly low survival rate mainly due to the lack of diagnostic markers for early detection and effective therapies. In the U.S., 75% of individuals diagnosed with esophageal squamous cell carcinoma (ESCC) are of Af

Externí odkaz: https://doaj.org/article/ca8d62a5f3954af2b113cef1574f176b

Impact of Pre-Analytical Variables on Cancer Targeted Gene Sequencing Efficiency.

Autor: Luiz H Araujo, Cynthia Timmers, Konstantin Shilo, Weiqiang Zhao, Jianying Zhang, Lianbo Yu, Thanemozhi G Natarajan, Clinton J Miller, Ayse Selen Yilmaz, Tom Liu, Joseph Amann, José Roberto Lapa E Silva, Carlos Gil Ferreira, David P Carbone

Publikováno v: PLoS ONE, Vol 10, Iss 11, p e0143092 (2015)

Tumor specimens are often preserved as formalin-fixed paraffin-embedded (FFPE) tissue blocks, the most common clinical source for DNA sequencing. Herein, we evaluated the effect of pre-sequencing parameters to guide proper sample selection for target

Externí odkaz: https://doaj.org/article/9c0d6c4bbe984059b2385d1738e3bb68

Biomarkers of Oxidative Stress in Cancer, and Their Clinical Implications

Autor: Thanemozhi G. Natarajan, Palanivel Gajalakshmi

Publikováno v: Handbook of Oxidative Stress in Cancer: Mechanistic Aspects ISBN: 9789811545016
Handbook of Oxidative Stress in Cancer: Mechanistic Aspects

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::995fb5787396d92f8ab6ad00b27e12d6
https://doi.org/10.1007/978-981-15-4501-6_174-1

Somatic Mutation Spectrum of Non–Small-Cell Lung Cancer in African Americans: A Pooled Analysis

Autor: Konstantin Shilo, Ayse Selen Yilmaz, Tom Liu, Philip E. Lammers, David P. Carbone, Thanemozhi G. Natarajan, Rosana Eisenberg, Velmalia Matthews-Smith, Cynthia Timmers, Adriana Gonzalez, Ann G. Schwartz, Luiz H. Araujo, Kevin R. Coombes, Weiqiang Zhao, Jianying Zhang

Publikováno v: Journal of Thoracic Oncology. 10(10):1430-1436

Introduction: The mutational profile of non–small-cell lung cancer (NSCLC) has become an important tool in tailoring therapy to patients, with clear differences according to the population of origin. African Americans (AAs) have higher lung cancer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::376d3c2711856ea8f0b041a92cb637ae

Tumor molecular profiling in advanced pediatric brain tumors

Autor: Gargi D. Basu, Szabolcs Szelinger, Tracey White, Janine LoBello, Thanemozhi G. Natarajan, Nathan Garinger, Candyce M Bair, Ahmet Kurdoglu, Thomas Royce

Publikováno v: Journal of Clinical Oncology. 37:e21516-e21516

e21516 Background: With the advent of high-throughput molecular profiling, clinical outcome in pediatric cancers has greatly improved due to our greater understanding of genetic origin of pediatric cancer, and availability of biomarker specific treat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d5de244e40f13deff4908408c6646371
https://doi.org/10.1200/jco.2019.37.15_suppl.e21516