Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Thandranese S. Owens"'
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Determination of methotrexate, 7-hydroxymethotrexate, and 2,4-diamino-N10-methylpteroic acid by LC–MS/MS in plasma and cerebrospinal fluid and application in a pharmacokinetic analysis of high-dose methotrexate
Autor: Vinay M. Daryani, Nicholas S. Selvo, Michael S. Roberts, Jessica K. Roberts, Amar Gajjar, Clinton F. Stewart, Thandranese S. Owens, K. Elaine Harstead
Publikováno v: Journal of Liquid Chromatography & Related Technologies. 39:745-751
A rapid and robust method for measuring methotrexate (MTX) and its two primary metabolites, 7-hydroxymethotrexate (7-OHMTX) and 2,4-diamino-N10-methylpteroic acid (DAMPA), was developed for use in pharmacokinetic studies of plasma and cerebrospinal f
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f5e1ce12a0cca68c1f07f2028d33dbf8
https://doi.org/10.1080/10826076.2016.1243558
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3
Factors influencing the intracellular exposure of gemcitabine triphosphate in children with CNS tumors
Autor: Nicholas S. Selvo, Clinton F. Stewart, Giles W. Robinson, Olivia Campagne, Thandranese S. Owens, Bo Zhong, Amar J. Gajjar
Publikováno v: Journal of Clinical Oncology. 37:e13547-e13547
e13547 Background: Gemcitabine (dFdC), a cytosine analog, is currently being evaluated as a therapy to treat children and young adults with central nervous systems (CNS) tumors in two clinical trials (NCT01878617 and NCT03434262). Once in the cell, d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d3ba4d3ea4b2121e31edfcf4f2390795
https://doi.org/10.1200/jco.2019.37.15_suppl.e13547
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4
Determination of crenolanib in human serum and cerebrospinal fluid by liquid chromatography–electrospray ionization-tandem mass spectrometry (LC–ESI-MS/MS)
Autor: Michael S, Roberts, David C, Turner, Thandranese S, Owens, Abhijit, Ramachandran, Cynthia, Wetmore, Stacy L, Throm, Clinton F, Stewart
Publikováno v: Journal of Chromatography B. 929:1-5
A LC-ESI-MS/MS method for the determination of crenolanib (CP-868,596) in human serum was developed and validated employing d4-CP-868,596 as an internal standard (ISTD). In addition to human serum, the method was also partially validated for crenolan
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c2586f61565b574effda1d6caf28348
https://doi.org/10.1016/j.jchromb.2013.04.002
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5
UGT1A1Promoter Genotype Correlates With SN-38 Pharmacokinetics, but Not Severe Toxicity in Patients Receiving Low-Dose Irinotecan
Autor: Charles H. Fraga, Tiebin Liu, Lisa M. McGregor, Stacy L. Throm, Clinton F. Stewart, Catherine A. Billups, Carlos Rodriguez-Galindo, Thandranese S. Owens, Amar Gajjar, Wayne L. Furman, Melinda A. O'Shaughnessy, John C. Panetta
Publikováno v: Journal of Clinical Oncology. 25:2594-2600
PurposeTo study the association between UDP-glucuronosyltransferase 1A1 (UGT1A1) genotypes and severe toxicity as well as irinotecan disposition in pediatric patients with solid tumors receiving low-dose, protracted irinotecan (15 to 75 mg/m2daily fo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34340aef3ee6cfe46c00ee586bba3b8c
https://doi.org/10.1200/jco.2006.10.2301
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6
High-performance liquid chromatographic assay with fluorescence detection for the simultaneous measurement of carboxylate and lactone forms of irinotecan and three metabolites in human plasma
Autor: Suzan K. Hanna, Katrin Fricke, Kristine R. Crews, Thandranese S. Owens, Helen M. Dodds
Publikováno v: Journal of Chromatography B. 788:65-74
Irinotecan (CPT-11), a camptothecin analog, is metabolized to SN-38, an active topoisomerase I inhibitor, and inactive metabolites, including APC and SN-38 glucuronide (SN-38G). A high-performance liquid chromatographic assay method to simultaneously
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a69474f79c93b1fcc10aa1254e401ba4
https://doi.org/10.1016/s1570-0232(02)01016-4
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7
Determination of Nutlin-3a in Murine Plasma by Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry (LC-ESI-MS/MS)
Autor: Clinton F. Stewart, Edward Derrick, Jeremy P. Mallari, Thandranese S. Owens, Feng Bai, Fangyi Zhu, Michael Tagen, Fan Zhang, Laura Miller
A sensitive and precise LC-ESI-MS/MS method for determination of nutlin-3a in murine plasma using ketoconazole as an internal standard was developed and validated. Plasma nutlin-3a samples were prepared by either a simple protein precipitation (PP) f
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ae15ca123ed4c50a259150c157b2762
https://europepmc.org/articles/PMC2814893/
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8
Determination of dopamine, serotonin, and their metabolites in pediatric cerebrospinal fluid by isocratic high performance liquid chromatography coupled with electrochemical detection
Autor: Clinton F. Stewart, Charles H. Fraga, Thandranese S. Owens, Michael Tagen, K. Elaine Hubbard, Amy Wells
Publikováno v: Biomedical Chromatography.
A method to rapidly measure dopamine (DA), dihydroxyindolphenylacetic acid, homovanillic acid, serotonin (5-HT) and 5-hydroxyindoleacetic acid concentrations in cerebrospinal fluid (CSF) has not yet been reported. A rapid, sensitive, and specific HPL
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7334a4171996293a428afb1a93809c1a
https://doi.org/10.1002/bmc.1338
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9
Abstract 4526: Age dependent disposition of cyclophosphamide (CTX) and metabolites in infants ≤ 1 year old with brain tumors
Autor: Vinay M. Daryani, Amar Gajjar, Yogesh T. Patel, Stacy L. Throm, Thandranese S. Owens, K. Elaine Harstead, John C. Panetta, David C. Turner, Clinton F. Stewart
Publikováno v: Cancer Research. 75:4526-4526
An ongoing trial of risk-adapted therapy for infants and young children < 3 yrs old diagnosed with brain tumors includes IV CTX (NCT00602667). One aim is to describe the pharmacokinetics (PK) of CTX, and 2 of its metabolites, the inactive carboxyethy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1594f36c501a81a084c64d809f01614b
https://doi.org/10.1158/1538-7445.am2015-4526
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