Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Thandi M. Onami"'
Autor:
John R Harp, Thandi M Onami
Publikováno v:
PLoS ONE, Vol 5, Iss 6, p e10973 (2010)
Selectin mediated tethering represents one of the earliest steps in T cell extravasation into lymph nodes via high endothelial venules and is dependent on the biosynthesis of sialyl Lewis X (sLe(x)) ligands by several glycosyltransferases, including
Externí odkaz:
https://doaj.org/article/962258f856234563ae1f8eee25d2c502
Publikováno v:
AIDS Research and Human Retroviruses. 29:1407-1417
A vital part of the renewed hope for a vaccine against the human immunodeficiency virus (HIV-1) is based on recent studies that have highlighted major sites of HIV-1 vulnerability that could be effectively targeted by a preventive vaccine. One of the
Autor:
Vishal J. Sindhava, Halide Tuna, Subbarao Bondada, Donald A. Cohen, Thomas F. Tedder, Thandi M. Onami, Beth W. Gachuki, Margarita G. Avdiushko, David J. DiLillo
Publikováno v:
The Journal of Immunology. 189:3355-3367
Dendritic cells (DCs) play an essential role in regulation of immune responses. In the periphery, Ag presentation by DCs is critical for adaptive responses; for this reason, DCs are often targets of adjuvants that enhance vaccine responses. Activated
Publikováno v:
Viral Immunology. 23:377-384
Immunoglobulins in secretions play a critical role in protection at mucosal surfaces. We examined the generation of viral-specific IgG and IgA in plasma and mucosal secretions of mice following systemic or mucosal immunization with lymphocytic chorio
Publikováno v:
The Journal of Immunology. 182:4721-4727
Posttranslational modification of proteins, such as glycosylation, can impact cell signaling and function. ST6Gal I, a glycosyltransferase expressed by B cells, catalyzes the addition of α-2,6 sialic acid to galactose, a modification found on N-link
Autor:
Thandi M. Onami, Sundaresan Venkatachalam, Sangeetha Rajagopalan, Prabakaran Nagarajan, Robert L. Donnell, Stephen A. Kania
Publikováno v:
Oncogene
The chromodomain helicase DNA binding proteins (CHDs) are known to affect transcription via their ability to remodel chromatin and modulate histone deacetylation. In an effort to understand the functional role of the chromodomain helicase DNA binding
Autor:
Tatsuro Irimura, Nobuaki Higashi, Thandi M. Onami, Yosuke Kumamoto, Yasuyuki Imai, Kayoko Sato, Stephen M. Hedrick
Publikováno v:
Blood. 106:207-215
Macrophage galactose-type C-type lectins (MGLs), which were recently named CD301, have 2 homologues in mice: MGL1 and MGL2. MGLs are expressed on macrophages and immature dendritic cells. The persistent presence of granulation tissue induced by a pro
Publikováno v:
The Journal of Immunology. 171:6527-6533
Experimental autoimmune encephalomyelitis (EAE) is a mouse model of multiple sclerosis characterized by infiltration of activated CD4+ T lymphocytes into tissues of the CNS. This study investigated the role of CD43 in the induction and progression of
Autor:
Thandi M. Onami, Tatsuro Irimura, Stephen M. Hedrick, Yoshimi Ohashi, Makoto Tsuiji, Mayuko Fujimori, Nobuaki Higashi
Publikováno v:
Journal of Biological Chemistry. 277:28892-28901
A novel mouse macrophage galactose-type C-type lectin 2 (mMGL2) was identified by BLAST analysis of expressed sequence tags. The sequence of mMGL2 is highly homologous to the mMGL, which should now be called mMGL1. The open reading frame of mMGL2 con
Publikováno v:
Seminars in Immunology. 8:69-82
Developing T cells which recognize self-proteins are specifically deleted by the process of negative selection in the thymus. This review summarizes data from both in-vitro and in-vivo systems on the cellular and biochemical requirements that play ro