Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Thamiya Vasanthakumar"'
Autor:
Thamiya Vasanthakumar, Kristine A. Keon, Stephanie A. Bueler, Michael C. Jaskolka, John L. Rubinstein
Publikováno v:
Nature Structural & Molecular Biology. 29:430-439
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f94504592dae0600f2dff872f68fa80c
https://doi.org/10.1038/s41594-022-00757-z
https://doi.org/10.1038/s41594-022-00757-z
Publikováno v:
Trends in Biochemical Sciences. 45:295-307
V-ATPases are membrane-embedded protein complexes that function as ATP hydrolysis-driven proton pumps. V-ATPases are the primary source of organellar acidification in all eukaryotes, making them essential for many fundamental cellular processes. Enzy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::367c33cd658115f9de6355e637eb9847
https://doi.org/10.1016/j.tibs.2019.12.007
https://doi.org/10.1016/j.tibs.2019.12.007
Autor:
Thamiya Vasanthakumar, Kristine A. Keon, Stephanie A. Bueler, Michael C. Jaskolka, John L. Rubinstein
Vacuolar-type ATPases (V-ATPases) are rotary enzymes that acidify intracellular compartments in eukaryotic cells. These multi-subunit complexes consist of a cytoplasmic V1 region that hydrolyzes ATP and a membrane-embedded VO region that transports p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97dd6d9b68e194c20011039c172e10f6
https://doi.org/10.1101/2021.11.09.467972
https://doi.org/10.1101/2021.11.09.467972
Autor:
Thamiya, Vasanthakumar, Kristine A, Keon, Stephanie A, Bueler, Michael C, Jaskolka, John L, Rubinstein
Publikováno v:
Nature structuralmolecular biology. 29(5)
Vacuolar-type ATPases (V-ATPases) are rotary enzymes that acidify intracellular compartments in eukaryotic cells. These multi-subunit complexes consist of a cytoplasmic V
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::46b23623378880cedfd9a10b254ee21c
https://pubmed.ncbi.nlm.nih.gov/35469063
https://pubmed.ncbi.nlm.nih.gov/35469063
Autor:
Bhairavi Tolani, Anna Celli, Yanmin Yao, Yong Zi Tan, Richard Fetter, Christina R. Liem, Adam J. de Smith, Thamiya Vasanthakumar, Paola Bisignano, Adam D. Cotton, Ian B. Seiple, John L. Rubinstein, Marco Jost, Jonathan S. Weissman
Publikováno v:
Nature biotechnology, vol 40, iss 12
Mutations in Ras family proteins are implicated in 33% of human cancers, but direct pharmacological inhibition of Ras mutants remains challenging. As an alternative to direct inhibition, we screened for sensitivities in Ras-mutant cells and discovere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39a71129bb71ed4aab46b2badda735d5
https://pubmed.ncbi.nlm.nih.gov/35879364
https://pubmed.ncbi.nlm.nih.gov/35879364
Autor:
Stephanie A. Bueler, Thamiya Vasanthakumar, Di Wu, Victoria Beilsten-Edmands, Carol V. Robinson, John L. Rubinstein
Publikováno v:
Proceedings of the National Academy of Sciences. 116:7272-7277
Proton-translocating vacuolar-type ATPases (V-ATPases) are necessary for numerous processes in eukaryotic cells, including receptor-mediated endocytosis, protein maturation, and lysosomal acidification. In mammals, V-ATPase subunit isoforms are diffe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efaa9a590bd366812253de6528905a76
https://doi.org/10.1073/pnas.1814818116
https://doi.org/10.1073/pnas.1814818116
Autor:
Yanmin Yao, Anna Celli, Jonathan S. Weissman, Christina R Liem, Thamiya Vasanthakumar, Richard D. Fetter, Bhairavi Tolani, Paola Bisignano, Marco Jost, Yong Zi Tan, John L. Rubinstein, Ian B. Seiple, Adam J. de Smith
Mutations in the Ras family of oncogenes are implicated in 33% of human cancers, making Ras an intensely pursued target in drug discovery. As an alternative to direct pharmacological inhibition of Ras, we looked for sensitivities in RAS mutant cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12da45d4be8d9bcf358a44a5ff5af0a2
https://doi.org/10.1101/2020.12.23.423300
https://doi.org/10.1101/2020.12.23.423300
Autor:
Thamiya, Vasanthakumar, Stephanie A, Bueler, Di, Wu, Victoria, Beilsten-Edmands, Carol V, Robinson, John L, Rubinstein
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 116(15)
Proton-translocating vacuolar-type ATPases (V-ATPases) are necessary for numerous processes in eukaryotic cells, including receptor-mediated endocytosis, protein maturation, and lysosomal acidification. In mammals, V-ATPase subunit isoforms are diffe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::36a650da03a6dc7847c6b3b4e30b3cb3
https://pubmed.ncbi.nlm.nih.gov/30910982
https://pubmed.ncbi.nlm.nih.gov/30910982
Publikováno v:
Science. 2/25/2022, Vol. 375 Issue 6583, p900-919. 28p. 3 Color Photographs.
Autor:
Tolani, Bhairavi, Celli, Anna, Yao, Yanmin, Tan, Yong Zi, Fetter, Richard, Liem, Christina R., de Smith, Adam J., Vasanthakumar, Thamiya, Bisignano, Paola, Cotton, Adam D., Seiple, Ian B., Rubinstein, John L., Jost, Marco, Weissman, Jonathan S.
Publikováno v:
Nature Biotechnology; Dec2022, Vol. 40 Issue 12, p1834-1844, 11p