Collaborative Virtual Screening Identifies a 2-Aryl-4-aminoquinazoline Series with Efficacy in an

Autor: Taisuke, Tawaraishi, Atsuko, Ochida, Yuichiro, Akao, Sachiko, Itono, Masahiro, Kamaura, Thamina, Akther, Mitsuyuki, Shimada, Stacie, Canan, Sanjoy, Chowdhury, Yafeng, Cao, Kevin, Condroski, Ola, Engkvist, Amanda, Francisco, Sunil, Ghosh, Rina, Kaki, John M, Kelly, Chiaki, Kimura, Thierry, Kogej, Kazuya, Nagaoka, Akira, Naito, Garry, Pairaudeau, Constantin, Radu, Ieuan, Roberts, David, Shum, Nao-Aki, Watanabe, Huanxu, Xie, Shuji, Yonezawa, Osamu, Yoshida, Ryu, Yoshida, Charles, Mowbray, Benjamin, Perry

Publikováno v: Journal of medicinal chemistry.

Probing multiple proprietary pharmaceutical libraries in parallel via virtual screening allowed rapid expansion of the structure-activity relationship (SAR) around hit compounds with moderate efficacy against

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::098120064a818c49ef6eba16a4ffb203
https://pubmed.ncbi.nlm.nih.gov/36607408

A brief review on novel pyrene based fluorometric and colorimetric chemosensors for the detection of Cu2+

Autor: Thamina Akther, Carl Redshaw, Zannatul Kowser, Ummey Rayhan, Takehiko Yamato

Publikováno v: Materials Chemistry Frontiers. 5:2173-2200

The development of colorimetric and fluorometric chemosensors that capable of detecting Cu2+ ions by a change in colour and fluorescence intensity has been described. Herein, chemosensors having pyrene functional groups as a signaling moiety are disc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ae1763982bf493613876e01854ea95c5
https://doi.org/10.1039/d0qm01008a

Nonbisphosphonate inhibitors of Plasmodium falciparum FPPS/GGPPS

Autor: Mark Smith, Atsuko Ochida, Stephanie Kabeche, Thamina Akther, Takashi Ichikawa, Michael J. Pulkoski-Gross, Jumpei Aida, Paul S. Humphries, Ellen Yeh

Publikováno v: Bioorganicmedicinal chemistry letters. 41

A series of novel thiazole-containing amides were synthesized. A structure-activity relationship study of these compounds led to the identification of potent and selective PfFPPS/GGPPS inhibitors with good in vitro ADME profiles. The most promising c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f589b25651e73127628ffa91a54ecc8
https://pubmed.ncbi.nlm.nih.gov/33766764

Synthesis and Structure of 1,2-Dimethylene[2.10]metacyclophane and Its Conversion into Chiral [10]Benzenometacyclophanes

Autor: Md. Monarul Islam, Carl Redshaw, Takehiko Yamato, Taisuke Matsumoto, Thamina Akther, Junji Tanaka, Pierre Thuéry

Publikováno v: European Journal of Organic Chemistry. 2017:1721-1726

Bromination of 5,21-di-tert-butyl-8,24-dimethoxy-1,2-dimethyl[2.10]metacyclophan-1-ene (MCP-1-ene; 1) with benzyltrimethylammonium tribromide exclusively afforded 1,2-bis(bromomethyl)-5,21-di-tert-butyl-8,24-dimethoxy[2.10]MCP-1-ene (2). Debrominatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::73be6d909e5dca34c045151560c7ae2a
https://doi.org/10.1002/ejoc.201601647

Synthesis, Structures and Conformational Studies of 1,2-Dimethyl[2.10]metacyclophan-1-enes

Autor: Shofiur Rahman, Thamina Akther, Taisuke Matsumoto, Carl Redshaw, Pierre Thuéry, Junji Tanaka, Paris E. Georghiou, Takehiko Yamato, Monarul Islam

Publikováno v: ChemistrySelect
ChemistrySelect, 2016, 1 (13), pp.3594-3600. ⟨10.1002/slct.201600670⟩
ChemistrySelect, Wiley, 2016, 1 (13), pp.3594-3600. ⟨10.1002/slct.201600670⟩

International audience; A series of 1,2‐dimethyl[2.10]metacyclophan‐1‐enes (MCP‐1‐enes) containing different substituent groups has been synthesized to illustrate their conformational behavior. 4,22‐dimethoxy‐1,2‐dimethyl[2.10]MCP‐1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1e196e91703f618f3d93d2b6e714b08
https://doi.org/10.1002/slct.201600670