Rapid evolution of colistin resistance in a bioreactor model of infection of Klebsiella pneumoniae

Autor: Juan-Carlos Jiménez-Castellanos, Bartlomiej Waclaw, Alison Meynert, Sean P. McAteer, Thamarai Schneiders

Publikováno v: Communications Biology, Vol 7, Iss 1, Pp 1-11 (2024)

Abstract Colistin remains an important antibiotic for the therapeutic management of drug-resistant Klebsiella pneumoniae. Despite the numerous reports of colistin resistance in clinical strains, it remains unclear exactly when and how different mutat

Externí odkaz: https://doaj.org/article/e7fedae6697e41a6b06a1e6a8797ff17

Editorial: Molecular mechanisms of resistance to 'last resort' antimicrobials in Enterobacterales

Autor: John Osei Sekyere, Thamarai Schneiders, Piotr Majewski

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)

Externí odkaz: https://doaj.org/article/82affbebe95f4a1184f39002d8d1222a

Elucidation of the RamA regulon in Klebsiella pneumoniae reveals a role in LPS regulation.

Autor: Shyamasree De Majumdar, Jing Yu, Maria Fookes, Sean P McAteer, Enrique Llobet, Sarah Finn, Shaun Spence, Avril Monahan, Avril Monaghan, Adrien Kissenpfennig, Rebecca J Ingram, José Bengoechea, David L Gally, Séamus Fanning, Joseph S Elborn, Thamarai Schneiders

Publikováno v: PLoS Pathogens, Vol 11, Iss 1, p e1004627 (2015)

Klebsiella pneumoniae is a significant human pathogen, in part due to high rates of multidrug resistance. RamA is an intrinsic regulator in K. pneumoniae established to be important for the bacterial response to antimicrobial challenge; however, litt

Externí odkaz: https://doaj.org/article/d280d78a40a04c13b06cf48c876f1155

Antibiotic Treatment Regimes as a Driver of the Global Population Dynamics of a Major Gonorrhea Lineage

Autor: Kristian Alfsnes, Lucy van Dorp, Thamarai Schneiders, Francois Balloux, Dominique A. Caugant, Ola Brønstad Brynildsrud, Kate Templeton, Vegard Eldholm, Koji Yahara, Magnus N Osnes

Publikováno v: Osnes, M N, van Dorp, L, Brynildsrud, O B, Alfsnes, K, Schneiders, T, Templeton, K, Yahara, K, Balloux, F, Caugant, D A & Eldholm, V 2020, ' Antibiotic treatment regimes as a driver of the global population dynamics of a major gonorrhea lineage ', Molecular Biology and Evolution, vol. 38, no. 4, pp. 1249–1261 . https://doi.org/10.1093/molbev/msaa282
Molecular Biology and Evolution
Molecular biology and evolution

The Neisseria gonorrhoeae multilocus sequence type (ST) 1901 is among the lineages most commonly associated with treatment failure. Here, we analyze a global collection of ST-1901 genomes to shed light on the emergence and spread of alleles associate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::675bbc95cfffea299541640dd965c875
https://doi.org/10.1093/molbev/msaa282

Envelope proteome changes driven by RamA overproduction in Klebsiella pneumoniae that enhance acquired β-lactam resistance

Autor: Kate J. Heesom, Juan-Carlos Jiménez-Castellanos, Matthew B. Avison, Jacqueline Findlay, Yuiko Takebayashi, Wan Ahmad Kamil Wan Nur Ismah, Thamarai Schneiders

Publikováno v: Jiménez-Castellanos, J-C, Wan Ahmad Kamil, W N I, Takebayashi, Y, Findlay, J, Schneiders, T, Heesom, K J & Avison, M B 2018, ' Envelope proteome changes driven by RamA overproduction in Klebsiella pneumoniae that enhance acquired β-lactam resistance ', Journal of Antimicrobial Chemotherapy, vol. 73, no. 1, dkx345, pp. 88-94 . https://doi.org/10.1093/jac/dkx345

Objectives: In Klebsiella pneumoniae, overproduction of RamA results in reduced envelope permeability and reduced antimicrobial susceptibility but clinically relevant resistance is rarely observed. Here we have tested whether RamA overproduction can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::811541098f4b53ef7a38c744bf8658a9
https://doi.org/10.1093/jac/dkx345