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pro vyhledávání: '"Thales Uchôa da Costa Sobrinho"'
Publikováno v:
Medicinal Chemistry Research. 28:1235-1245
In the process of research and development of new drugs, in silico analyzes are widely used. They address the pharmacokinetics of the molecules in study and can predict the binding mode and affinity, using a docking software. This approach can optimi
Autor:
Márcia Maria de Souza, Tiago Coelho de Assis Lage, Ana Paula Dalmagro, Bernardo Carlesso Pinto, Camila André Cazarin, Thales Uchôa da Costa Sobrinho, Ângelo de Fátima, Luisa Mota da Silva, Ana Elisa Gonçalves, Luiz Carlos Klein-Júnior, Thaís Savoldi Lorenzett, Thaise Boeing, Rogério Corrêa, Sergio Antonio Fernandes
Publikováno v:
Behavioural Brain Research. 397:112945
Alzheimer's disease (AD) is the most prevalent form of dementia with a complex pathophysiology not fully elucidated but with limited pharmacological treatment. The Usnic acid (UA) is a lichen secondary metabolite found in two enantiomeric forms: (R)-