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pro vyhledávání: '"Thales Nepomuceno"'
Autor:
Marcelo Carvalho, Jean Yves Masson, Jacques Simard, Thales Nepomuceno, Alvaro Monteiro, Amélie Rodrigue, Francine Durocher
Publikováno v:
Trends in cancer. 7(3)
Since its discovery, partner and localizer of breast cancer 2 (BRCA2) (PALB2) has emerged as a major tumor suppressor gene linked to breast cancer (BC), pancreatic cancer (PC), and ovarian cancer (OC) susceptibility. Its protein product plays a pivot
Autor:
Ou Deng, Sweta Dash, Thales Nepomuceno, Bin Fang, Douglas Marchion, John Koomen, Alvaro N. Monteiro, Uwe Rix
Publikováno v:
Molecular Cancer Therapeutics. 20:P018-P018
Background: About 40-50% of epithelial ovarian cancers (EOC) show defects in DNA repair by homologous recombination (HR), which are mostly associated with BRCA1/2 loss-of-function mutations. The PARP inhibitors (PARPis) olaparib, niraparib and rucapa