Zobrazeno 1 - 10
of 106
pro vyhledávání: '"Thales Kronenberger"'
Autor:
Stephan Spahn, Fabian Kleinhenz, Ekaterina Shevchenko, Aaron Stahl, Yvonne Rasen, Christine Geisler, Kristina Ruhm, Marion Klaumuenzer, Thales Kronenberger, Stefan A. Laufer, Holly Sundberg-Malek, Khac Cuong Bui, Marius Horger, Saskia Biskup, Klaus Schulze-Osthoff, Markus Templin, Nisar P. Malek, Antti Poso, Michael Bitzer
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Fibroblast growth factor receptor (FGFR)−2 can be inhibited by FGFR-selective or non-selective tyrosine kinase inhibitors (TKIs). Selective TKIs are approved for cholangiocarcinoma (CCA) with FGFR2 fusions; however, their application is li
Externí odkaz:
https://doaj.org/article/4e23905b41b4488d8d1d8c66053fe10f
Autor:
Maurício T. Tavares, Arne Krüger, Sun L. Rei Yan, Karoline B. Waitman, Vinícius M. Gomes, Daffiny Sumam de Oliveira, Franciarli Paz, Sebastian Hilscher, Mike Schutkowski, Wolfgang Sippl, Claudia Ruiz, Mônica F. Z. J. Toledo, Neuza M. A. Hassimotto, João A. Machado-Neto, Antti Poso, Michael D. Cameron, Thomas D. Bannister, Giuseppe Palmisano, Carsten Wrenger, Thales Kronenberger, Roberto Parise-Filho
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-20 (2023)
Abstract We report a series of 1,3-diphenylureido hydroxamate HDAC inhibitors evaluated against sensitive and drug-resistant P. falciparum strains. Compounds 8a–d show potent antiplasmodial activity, indicating that a phenyl spacer allows improved
Externí odkaz:
https://doaj.org/article/661e63afc62b4a918f5086fa3323ea43
Autor:
Julia de Paula Dutra, Gustavo Scheiffer, Thales Kronenberger, Lucas Julian Cruz Gomes, Isadora Zanzarini, Kelly Karoline dos Santos, Arun K. Tonduru, Antti Poso, Fabiane Gomes de Moraes Rego, Geraldo Picheth, Glaucio Valdameri, Vivian Rotuno Moure
Publikováno v:
EXCLI Journal : Experimental and Clinical Sciences, Vol 22, Pp 1155-1172 (2023)
A current clinical challenge in cancer is multidrug resistance (MDR) mediated by ABC transporters. Breast cancer resistance protein (BCRP) or ABCG2 transporter is one of the most important ABC transporters implicated in MDR and the use of inhibitors
Externí odkaz:
https://doaj.org/article/89c372996acc4eafb0e43f13022f3e07
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Chagas disease is caused by the protozoan parasite Trypanosoma cruzi. The disease has an acute and a chronic phase in which approximately 30% of the chronic patients suffer from heart disease and/or gastrointestinal symptoms. The pathogenesi
Externí odkaz:
https://doaj.org/article/c2323972c0c44a0b8c5060cac8445e99
Autor:
Marcell Crispim, Ignasi Bofill Verdaguer, Agustín Hernández, Thales Kronenberger, Àngel Fenollar, Lydia Fumiko Yamaguchi, María Pía Alberione, Miriam Ramirez, Sandra Souza de Oliveira, Alejandro Miguel Katzin, Luis Izquierdo
Publikováno v:
PLoS Pathogens, Vol 20, Iss 1, p e1011557 (2024)
A proposed treatment for malaria is a combination of fosmidomycin and clindamycin. Both compounds inhibit the methylerythritol 4-phosphate (MEP) pathway, the parasitic source of farnesyl and geranylgeranyl pyrophosphate (FPP and GGPP, respectively).
Externí odkaz:
https://doaj.org/article/237ca26c1906426da1acea6b60a8f15a
Autor:
Mateus Sá Magalhães Serafim, Thales Kronenberger, Renata Barbosa de Oliveira, Erna Geessien Kroon, Jônatas Santos Abrahão, Bruno Eduardo Fernandes Mota, Vinícius Gonçalves Maltarollo
Publikováno v:
Future Pharmacology, Vol 3, Iss 2, Pp 364-378 (2023)
Arboviral diseases caused by flaviviruses, such as dengue, are a continuing threat and major concern worldwide, with over three billion people estimated to be living with the risk of dengue virus (DENV) infections. There are thus far no antiviral dru
Externí odkaz:
https://doaj.org/article/39c39f485a6244659439dbe0da2adf6b
Autor:
Glaucio Monteiro Ferreira, Thanigaimalai Pillaiyar, Mario Hiroyuki Hirata, Antti Poso, Thales Kronenberger
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract SARS-CoV-2’s papain-like protease (PLpro) interaction with ligands has recently been explored with a myriad of crystal structures. We used molecular dynamics (MD) simulations to study different PLpro-ligand complexes, their ligand-induced
Externí odkaz:
https://doaj.org/article/dfe3ab47bcb4485094a466b0939f4073
Autor:
Azam Rashidian, Enni-Kaisa Mustonen, Thales Kronenberger, Matthias Schwab, Oliver Burk, Stefan A. Laufer, Tatu Pantsar
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 3004-3018 (2022)
Pregnane X receptor (PXR) is a nuclear receptor with an essential role in regulating drug metabolism genes. While the mechanism of action for ligand-mediated PXR agonism is well-examined, its ligand-mediated inhibition or antagonism is poorly underst
Externí odkaz:
https://doaj.org/article/390d4c67451d49668c763e41795e9da7
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/868361f16ba944ccb20bb5bc78451185
Autor:
Glaucio Valdameri, Diogo Henrique Kita, Julia de Paula Dutra, Diego Lima Gomes, Arun Kumar Tonduru, Thales Kronenberger, Bruno Gavinho, Izadora Volpato Rossi, Mariana Mazetto de Carvalho, Basile Pérès, Ingrid Fatima Zattoni, Fabiane Gomes de Moraes Rego, Geraldo Picheth, Rilton Alves de Freitas, Antti Poso, Suresh V. Ambudkar, Marcel I. Ramirez, Ahcène Boumendjel, Vivian Rotuno Moure
Publikováno v:
Pharmaceutics, Vol 15, Iss 4, p 1259 (2023)
Inhibition of ABC transporters is a promising approach to overcome multidrug resistance in cancer. Herein, we report the characterization of a potent ABCG2 inhibitor, namely, chromone 4a (C4a). Molecular docking and in vitro assays using ABCG2 and P-
Externí odkaz:
https://doaj.org/article/7e41a2636a89473abced9f9c7c0145b8