SOCS3 Ablation in Leptin Receptor-Expressing Cells Causes Autonomic and Cardiac Dysfunctions in Middle-Aged Mice despite Improving Energy and Glucose Metabolism

Autor: João A. B. Pedroso, Ivson B. da Silva, Thais T. Zampieri, Leonardo T. Totola, Thiago S. Moreira, Ana P. T. Taniguti, Gabriela P. Diniz, Maria Luiza M. Barreto-Chaves, Jose Donato

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 12, p 6484 (2022)

Leptin resistance is a hallmark of obesity. Treatments aiming to improve leptin sensitivity are considered a promising therapeutical approach against obesity. However, leptin receptor (LepR) signaling also modulates several neurovegetative aspects, s

Externí odkaz: https://doaj.org/article/1ebc96f0690649ecbcbd7de84212cb6a

Reviewing the Effects of l-Leucine Supplementation in the Regulation of Food Intake, Energy Balance, and Glucose Homeostasis

Autor: João A.B. Pedroso, Thais T. Zampieri, Jose Donato

Publikováno v: Nutrients, Vol 7, Iss 5, Pp 3914-3937 (2015)

Leucine is a well-known activator of the mammalian target of rapamycin (mTOR). Because mTOR signaling regulates several aspects of metabolism, the potential of leucine as a dietary supplement for treating obesity and diabetes mellitus has been invest

Externí odkaz: https://doaj.org/article/6612028af7fa4fc3bd055a486739ecab

l-Leucine Supplementation Worsens the Adiposity of Already Obese Rats by Promoting a Hypothalamic Pattern of Gene Expression that Favors Fat Accumulation

Autor: Thais T. Zampieri, Francisco L. Torres-Leal, Amanda B. Campaña, Fabio B. Lima, Jose Donato Jr.

Publikováno v: Nutrients, Vol 6, Iss 4, Pp 1364-1373 (2014)

Several studies showed that l-leucine supplementation reduces adiposity when provided before the onset of obesity. We studied rats that were exposed to a high-fat diet (HFD) for 10 weeks before they started to receive l-leucine supplementation. Fat m

Externí odkaz: https://doaj.org/article/a6f0ef4f4dc5498e8e8e8c9d617f5316

Reproductive neuronal circuitry in adaptive changes of energy balance

Autor: Thais T. Zampieri, Marina A. Silveira, Nicole Bellefontaine, Kevin W. Williams, Cristina Sáenz de Miera, Jose Donato, Renata Frazão, Pilhwa Lee, Carol F. Elias

The crosstalk between metabolism and reproduction is essential for species survival. When dysfunctional, this interaction may decrease reproductive efficiency, but in physiological conditions of high energy demands, e.g., pregnancy and lactation, it

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8b1e5e7422430ff5a1c33f342e02c58e
https://doi.org/10.1101/2021.09.09.459635

Postnatal Overnutrition Induces Changes in Synaptic Transmission to Leptin Receptor-Expressing Neurons in the Arcuate Nucleus of Female Mice

Autor: Thais T. Zampieri, Tabata Mariz Bohlen, Larissa Campista Lana, Renata Frazão, Jose Donato, Daniella G. de Paula, Marina A. Silveira

Publikováno v: Nutrients, Vol 12, Iss 2425, p 2425 (2020)
Nutrients
Volume 12
Issue 8
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

The adipocyte-derived hormone leptin is a potent neurotrophic factor that contributes to the neural plasticity and development of feeding circuitry, particularly in the arcuate nucleus of the hypothalamus (ARH). Postnatal overnutrition affects leptin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6dd143890c58de91d2285838ad46a78
https://www.mdpi.com/2072-6643/12/8/2425