Simultaneous Quantification of Antidiabetic Agents in Human Plasma by a UPLC-QToF-MS Method.

Autor: Mariana Millan Fachi, Letícia Bonancio Cerqueira, Letícia Paula Leonart, Thais Martins Guimarães de Francisco, Roberto Pontarolo

Publikováno v: PLoS ONE, Vol 11, Iss 12, p e0167107 (2016)

An ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry method for the simultaneous quantification of chlorpropamide, glibenclamide, gliclazide, glimepiride, metformin, nateglinide, pioglitazone, rosiglitazone, and vild

Externí odkaz: https://doaj.org/article/64b0b5dea17e475b8ef51f7fd7eff4f0

New Metabolites of Coumarin Detected in Human Urine Using Ultra Performance Liquid Chromatography/Quadrupole-Time-of-Flight Tandem Mass Spectrometry

Autor: Letícia Paula Leonart, João Cleverson Gasparetto, Flávia Lada Degaut Pontes, Letícia Bonancio Cerqueira, Thais Martins Guimarães de Francisco, Roberto Pontarolo

Publikováno v: Molecules, Vol 22, Iss 11, p 2031 (2017)

Coumarin (1,2-benzopyrone) is a natural compound whose metabolism in humans was established in the 1970s. However, a new metabolite was recently identified in human plasma, indicating that the metabolism of coumarin has not been completely elucidated

Externí odkaz: https://doaj.org/article/1d4ece56527443d9896e8aef5b6e827f

Rapid detection of aspergillosis in immunocompromised patients using DIMS and chemometric analysis

Autor: João Cleverson Gasparetto, Francinete Ramos Campos, Mário S. Piantavini, Isabela F. Zaramella, Letícia Bonancio Cerqueira, Roberto Pontarolo, Thais Martins Guimarães de Francisco

Publikováno v: Analytical Methods. 7:6346-6351

Rapid diagnosis of aspergillosis is one of the most important aspects for disease control and treatment. The purpose of this study was to develop a metabolic fingerprint of serum from immunocompromised patients that can enable rapid detection of aspe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f269f11621b55540a4a0c48c9a9810ce
https://doi.org/10.1039/c5ay01146a

Simultaneous determination of levodopa, carbidopa, entacapone, tolcapone, 3-O-methyldopa and dopamine in human plasma by an HPLC-MS/MS method

Autor: Rômulo Pereira, Ribeiro, João Cleverson, Gasparetto, Raquel, de Oliveira Vilhena, Thais Martins, Guimarães de Francisco, Thais Martins Guimarães, de Francisco, Cleverson Antônio Ferreira, Martins, Marco André, Cardoso, Roberto, Pontarolo, Katherine Athayde Teixeira, de Carvalho

Publikováno v: Bioanalysis. 7(2)

Background: In this study, we developed and validated a HPLC–MS/MS method capable of simultaneously determining levodopa, carbidopa, entacapone, tolcapone, 3-O-methyldopa and dopamine in human plasma. Results & methodology: Chromatographic separati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5e36cc092a4fea50d67389041657354
https://pubmed.ncbi.nlm.nih.gov/25961366

New Metabolites of Coumarin Detected in Human Urine Using Ultra Performance Liquid Chromatography/Quadrupole-Time-of-Flight Tandem Mass Spectrometry

Autor: Thais Martins Guimarães de Francisco, Flávia Lada Degaut Pontes, Roberto Pontarolo, Letícia P. Leonart, Letícia Bonancio Cerqueira, João Cleverson Gasparetto

Publikováno v: Molecules, Vol 22, Iss 11, p 2031 (2017)
Molecules; Volume 22; Issue 11; Pages: 2031
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry

Coumarin (1,2-benzopyrone) is a natural compound whose metabolism in humans was established in the 1970s. However, a new metabolite was recently identified in human plasma, indicating that the metabolism of coumarin has not been completely elucidated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::954fa8beb70a5a4237e7385165d0550e
https://doi.org/10.3390/molecules22112031