Beyond tobacco: genomic disparities in lung cancer between smokers and never-smokers

Autor: Javiera Garrido, Yanara Bernal, Evelin González, Alejandro Blanco, Gonzalo Sepúlveda-Hermosilla, Matías Freire, Karen Oróstica, Solange Rivas, Katherine Marcelain, Gareth Owen, Carolina Ibañez, Alejandro Corvalan, Marcelo Garrido, Rodrigo Assar, Rodrigo Lizana, Javier Cáceres-Molina, Diego Ampuero, Liliana Ramos, Paola Pérez, Osvaldo Aren, Sara Chernilo, Cristina Fernández, María Loreto Spencer, Jacqueline Flores Aguila, Giuliano Bernal Dossetto, Mónica Ahumada Olea, Germán Rasse, Carolina Sánchez, Maria Galli de Amorim, Thais F. Bartelli, Diana Noronha Nunes, Emmanuel Dias-Neto, Helano C. Freitas, Ricardo Armisén

Publikováno v: BMC Cancer, Vol 24, Iss 1, Pp 1-15 (2024)

Abstract Background Tobacco use is one of the main risk factors for Lung Cancer (LC) development. However, about 10–20% of those diagnosed with the disease are never-smokers. For Non-Small Cell Lung Cancer (NSCLC) there are clear differences in bot

Externí odkaz: https://doaj.org/article/299f116c68364c9a8cb95e5dde0ba0e8

Bacterial and fungal characterization of pancreatic adenocarcinoma from Endoscopic Ultrasound-guided biopsies

Autor: Robin D. Wright, Thais F. Bartelli, Seyda Baydogan, James Robert White, Michael P. Kim, Manoop S. Bhutani, Florencia McAllister

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

IntroductionThe tumor microbiome (TM) has been linked to pancreatic cancer prognosis. Specific microbes can confer tumor resistance to therapies. Early knowledge of the TM at time of diagnosis would be clinically relevant for precision therapy based

Externí odkaz: https://doaj.org/article/0ac02d25bf604d36901b4bfabb381546

Variability and Bias in Microbiome Metagenomic Sequencing: an Interlaboratory Study Comparing Experimental Protocols

Autor: Samuel P. Forry, Stephanie L. Servetas, Jason G. Kralj, Keng Soh, Michalis Hadjithomas, Raul Cano, Martha Carlin, Maria G de Amorim, Benjamin Auch, Matthew G Bakker, Thais F Bartelli, Juan P. Bustamante, Ignacio Cassol, Mauricio Chalita, Emmanuel Dias-Neto, Aaron Del Duca, Daryl M. Gohl, Jekaterina Kazantseva, Muyideen T. Haruna, Peter Menzel, Bruno S Moda, Lorieza Neuberger-Castillo, Diana N Nunes, Isha R. Patel, Rodrigo D. Peralta, Adrien Saliou, Rolf Schwarzer, Samantha Sevilla, Isabella K T M Takenaka, Jeremy R. Wang, Rob Knight, Dirk Gevers, Scott A. Jackson

BackgroundSeveral studies have documented the significant impact of methodological choices in microbiome analyses. The myriad of methodological options available complicate the replication of results and generally limit the comparability of findings

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::70332dd7ea0edd61b896d06cc8a91aa8
https://doi.org/10.1101/2023.04.28.538741

Increased DNA content in stomach fluids: diagnostic implications of a possible new gastric cancer marker

Autor: Francine Carla Cadoná, Adriane Graicer Pelosof, Claudia Zitron Sztokfisz, Adriana Passos Bueno, Luana Batista do Carmo dos Santos, Gabriela Pereira Branco, Gabriel Oliveira dos Santos, Warley Abreu Nunes, Fernanda Araújo Pintor, Laís Lie Senda de Abrantes, Alexandre Defelicibus, Luiz Gonzaga Vaz Coelho, Marcis Leja, Felipe José Fernandez Coimbra, Rodrigo D. Drummond, Israel Tojal da Silva, Thais F. Bartelli, Diana Noronha Nunes, Emmanuel Dias-Neto

ObjectiveTo investigate the diagnostic and prognostic role of gastric fluid DNA (gfDNA) in gasric cancer (GC) patients and controls submitted to upper digestive endoscopy.DesignThe concentration of gfDNA was evaluated in 941 samples, including subjec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0c12b7561a48a13f6c53103b39bb6f5d
https://doi.org/10.1101/2023.02.14.23285919

Concordance Analysis of ALK Gene Fusion Detection Methods in Patients with Non-Small-Cell Lung Cancer from Chile, Brazil, and Peru

Autor: Gonzalo Sepúlveda-Hermosilla, Matías Freire, Alejandro Blanco, Javier Cáceres, Rodrigo Lizana, Liliana Ramos, Rodrigo Assar Cuevas, Diego Ampuero, Osvaldo Aren, Sara Chernilo, María L. Spencer, Giuliano Bernal, Jacqueline Flores, Germán Rasse, Carolina Sánchez, Katherine Marcelain, Solange Rivas, Gabriela P. Branco, María Galli de Amorim, Diana N. Nunes, Emmanuel Dias-Neto, Helano C. Freitas, Cristina Fernández, Paola Pérez, Ricardo Armisén, Luiz Araujo, Luis Pires, Nils Skare, Gustavo Girotto, Manuela Zereu, Helano Freitas, Hakaru Tadokoro, Ana Caroline Gelatti, Jose Fernando Moura, Clarissa Mathias, Pedro Rafael De Marchi, Fernando Silva, Mayler Olombrada Nunes de Santos, Marianna Deway Andrade Dracoulakis, Renata Pinho Costa, Luciana Castro, Paulo Guilherme de Oliveira Salles, Clodoaldo Zago Campos, Maria Andrade Livia, Osvaldo Arén Frontera, Eduardo Yanez Ruiz, Monica Ahumada Olea, Loreto Spencer, Alejandro Ortega Vasquez, German Rasse, Juan Bertoglio, Jose David Zorrilla Silvera, Hernan Moron Escobar, Luis Riva Gonzalez, Luis Alberto Mas Lopez, José Luis Fernando Hurtado De Mendoza Acurio, Giovanna Victoria Abrill Mendoza, Alfredo Aguilar, Gerardo Campos Siccha, Ricardo Sanchez Sevillano, Sylvia Chandía, Pablo Araos, Ana Mejías, Francisca Angulo, Jessica Troncoso, David Jara, Marcela Astete, María Jesús Galleguillos, Helano Carioca Freitas, Diana Noronha Nunes, Gabriela Branco, Marina Eloi, Melissa Pizzi, Jordana Silva, Thais F. Bartelli, Jessica Toro, Luciana Oliveira-Cruz, Daniela Diez

Publikováno v: The Journal of molecular diagnostics : JMD. 23(9)

About 4% to 7% of the non–small-cell lung cancer patients have anaplastic lymphoma kinase (ALK) rearrangements, and specific targeted therapies improve patients' outcomes significantly. ALK gene fusions are detected by immunohistochemistry or fluor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88a8b21a25b5a16472f51facac5bc122
https://pubmed.ncbi.nlm.nih.gov/34186175