Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Thais Federici"'
Autor:
Muhibullah S. Tora, Stewart G. Neill, Yuliya Lakhina, Hemza Assed, Michelle Zhang, Purva P. Nagarajan, Thais Federici, Juanmarco Gutierrez, Kimberly B. Hoang, Yuhong Du, Kecheng Lei, Nicholas M. Boulis
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-12 (2023)
Abstract Background Spinal cord glioma (SCG) is considered an orphan disease that lacks effective treatment options with margins that are surgically inaccessible and an overall paucity of literature on the topic. The tumor microenvironment is a criti
Externí odkaz:
https://doaj.org/article/32602bf37c574cc6a654e0f3b3fc2421
Autor:
Nicholas M. Boulis, Pavlos Texakalidis, Jonathan Riley, Nathan Hardcastle, Thais Federici, Muhibullah S Tora, Jeremy Wetzel
Publikováno v:
Stereotactic and Functional Neurosurgery. 99:322-328
This manuscript introduces the latest generation of a patient-mounted platform designed for segmental injections of therapeutics direct into the spinal cord parenchyma. It emphasizes its importance and it presents the rationale for developing this de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbe770bd19ee2b3271e9cdda3ef1e8e9
https://doi.org/10.1159/000512504
https://doi.org/10.1159/000512504
Autor:
Thais Federici, Nicholas M. Boulis
Publikováno v:
Neurobiology of Disease, Vol 48, Iss 2, Pp 236-242 (2012)
Gene therapy continues to be a potential option for amyotrophic lateral sclerosis (ALS). This chapter will inform the reader about promising therapeutic transgenes and proof-of-principle studies in transgenic rodent models of ALS. Challenges regardin
Externí odkaz:
https://doaj.org/article/8d39d012833748dbb95532369fe2474a
Autor:
Eleanor M. Donnelly, Eric T. Quach, Terence M. Hillery, Brenten L. Heeke, Brooke R. Snyder, Chalonda R. Handy, Deirdre M. O'Connor, Nicholas M. Boulis, Thais Federici
Publikováno v:
Neurobiology of Disease, Vol 45, Iss 3, Pp 992-998 (2012)
Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disease, which is the leading genetic cause of mortality in children. To date no effective treatment exists for SMA. The genetic basis for SMA has been well documented as a mutatio
Externí odkaz:
https://doaj.org/article/8b865ceb2cc341f8b50a0739c7a8b385
Autor:
Colin K. Franz, Thais Federici, Jun Yang, Carey Backus, Sang Su Oh, Qingshan Teng, Erin Carlton, Kathie M. Bishop, Mehdi Gasmi, Raymond T. Bartus, Eva L. Feldman, Nicholas M. Boulis
Publikováno v:
Neurobiology of Disease, Vol 33, Iss 3, Pp 473-481 (2009)
Background: Amyotrophic lateral sclerosis (ALS) is a devastating disease that is characterized by the progressive loss of motor neurons. Patients with ALS usually die from respiratory failure due to respiratory muscle paralysis. Consequently, therapi
Externí odkaz:
https://doaj.org/article/b08a536399554ec89b5daddd1dab6e3b
Autor:
Muhibullah S Tora, Kecheng Lei, Purva P Nagarajan, David P Bray, Rima S Rindler, Stewart G Neill, Michelle Zhang, Pavlos Texakalidis, Andrey Krasnopeyev, Crystal Gergye, Raphael James, John N Oshinski, Thais Federici, Jeffrey N Bruce, Peter Canoll, Nicholas M Boulis
Publikováno v:
Neuro-Oncology. 24:vii297-vii297
BACKGROUND The current literature does not describe a reproducible large animal model of intracranial high-grade glioma (HGG). Prior work has demonstrated the feasibility of inducing HGG de-novo in rodents by targeting specific oncogenic pathways. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a680c9689e9f1f1fd981fa6372817f2a
https://doi.org/10.1093/neuonc/noac209.1155
https://doi.org/10.1093/neuonc/noac209.1155
Autor:
Qingshan Teng, Mary Garrity-Moses, Thais Federici, Diana Tanase, James K. Liu, Nicholas D. Mazarakis, Mimoun Azzouz, Lucy E. Walmsley, Erin Carlton, Nicholas M. Boulis
Publikováno v:
Neurobiology of Disease, Vol 20, Iss 3, Pp 694-700 (2005)
The present study examines gene delivery to cultured motor neurons (MNs) with the Rabies G protein (RabG)-pseudotyped lentiviral equine infectious anemia virus (RabG.EIAV) vector. RabG.EIAV-mediated β-galactosidase (RabG.EIAV-LacZ) gene expression i
Externí odkaz:
https://doaj.org/article/fadd0179677e4a0992f20be438f51d4e
Autor:
James K. Liu, Qingshan Teng, Mary Garrity-Moses, Thais Federici, Diana Tanase, Michael J. Imperiale, Nicholas M. Boulis
Publikováno v:
Neurobiology of Disease, Vol 19, Iss 3, Pp 407-418 (2005)
A novel peptide with the binding characteristics of tetanus toxin was identified with phage display, for application in therapeutic protein and vector motor and sensory neuron targeting. A 12mer phage library was biopanned on trisialoganglioside (GT1
Externí odkaz:
https://doaj.org/article/145aa52bf79342f19e5fed3f18b7b2ac
Autor:
Jeffrey Javidfar, Anthony Donsante, Thais Federici, Pavlos Texakalidis, Nicholas M. Boulis, Skyler Canute, Nathan Hardcastle, Muhibullah S Tora, Kelly M. Poth
Publikováno v:
Neurosurgery. 87:847-853
Background Neurodegenerative diseases and spinal cord injury can affect respiratory function often through motor neuron loss innervating the diaphragm. To reinnervate this muscle, new motor neurons could be transplanted into the phrenic nerve (PN), a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69a33378ba9133253e8e4c69718d5d05
https://doi.org/10.1093/neuros/nyz473
https://doi.org/10.1093/neuros/nyz473
Autor:
Muhibullah S Tora, Nicholas M. Boulis, Jennifer Novek, Thais Federici, Randy Pielemeier, Tony Arulanandam, Stephen Frey, Nathan Hardcastle, Mark D Johnson, Jeremy Wetzel
Publikováno v:
Stereotactic and Functional Neurosurgery. 97:293-302
Background: Stereotactic targeting techniques in nonhuman primate (NHP) models are often utilized in the preclinical investigation of new drug therapies with the goal of demonstrating accurate and reliable delivery of a therapy to the target tissue.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ef3f3a20d3baee50166ad67d0e52665
https://doi.org/10.1159/000504858
https://doi.org/10.1159/000504858