Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Thahira, Rahman"'
Autor:
Friedrich Stölzel, Sarah E. Fordham, Devi Nandana, Wei-Yu Lin, Helen Blair, Claire Elstob, Hayden L. Bell, Brigitte Mohr, Leo Ruhnke, Desiree Kunadt, Claudia Dill, Daniel Allsop, Rachel Piddock, Emmanouela-Niki Soura, Catherine Park, Mohd Fadly, Thahira Rahman, Abrar Alharbi, Manja Wobus, Heidi Altmann, Christoph Röllig, Lisa Wagenführ, Gail L. Jones, Tobias Menne, Graham H. Jackson, Helen J. Marr, Jude Fitzgibbon, Kenan Onel, Manja Meggendorfer, Amber Robinson, Zuzanna Bziuk, Emily Bowes, Olaf Heidenreich, Torsten Haferlach, Sara Villar, Beñat Ariceta, Rosa Ayala Diaz, Steven J. Altschuler, Lani F. Wu, Felipe Prosper, Pau Montesinos, Joaquin Martinez-Lopez, Martin Bornhäuser, James M. Allan
Publikováno v:
JCI Insight, Vol 8, Iss 2 (2023)
Precision medicine can significantly improve outcomes for patients with cancer, but implementation requires comprehensive characterization of tumor cells to identify therapeutically exploitable vulnerabilities. Here, we describe somatic biallelic TET
Externí odkaz:
https://doaj.org/article/099cf4b757194708b07592874d0436b2
Autor:
Wei-Yu Lin, Sarah E. Fordham, Eric Hungate, Nicola J. Sunter, Claire Elstob, Yaobo Xu, Catherine Park, Anne Quante, Konstantin Strauch, Christian Gieger, Andrew Skol, Thahira Rahman, Lara Sucheston-Campbell, Junke Wang, Theresa Hahn, Alyssa I. Clay-Gilmour, Gail L. Jones, Helen J. Marr, Graham H. Jackson, Tobias Menne, Mathew Collin, Adam Ivey, Robert K. Hills, Alan K. Burnett, Nigel H. Russell, Jude Fitzgibbon, Richard A. Larson, Michelle M. Le Beau, Wendy Stock, Olaf Heidenreich, Abrar Alharbi, David J. Allsup, Richard S. Houlston, Jean Norden, Anne M. Dickinson, Elisabeth Douglas, Clare Lendrem, Ann K. Daly, Louise Palm, Kim Piechocki, Sally Jeffries, Martin Bornhäuser, Christoph Röllig, Heidi Altmann, Leo Ruhnke, Desiree Kunadt, Lisa Wagenführ, Heather J. Cordell, Rebecca Darlay, Mette K. Andersen, Maria C. Fontana, Giovanni Martinelli, Giovani Marconi, Miguel A. Sanz, José Cervera, Inés Gómez-Seguí, Thomas Cluzeau, Chimène Moreilhon, Sophie Raynaud, Heinz Sill, Maria Teresa Voso, Francesco Lo-Coco, Hervé Dombret, Meyling Cheok, Claude Preudhomme, Rosemary E. Gale, David Linch, Julia Gaal-Wesinger, Andras Masszi, Daniel Nowak, Wolf-Karsten Hofmann, Amanda Gilkes, Kimmo Porkka, Jelena D. Milosevic Feenstra, Robert Kralovics, David Grimwade, Manja Meggendorfer, Torsten Haferlach, Szilvia Krizsán, Csaba Bödör, Friedrich Stölzel, Kenan Onel, James M. Allan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Genome wide association studies in cancer are used to understand the heritable genetic contribution to disease risk. Here, the authors perform a genome wide association study in European patients with acute myeloid leukemia and identify loci associat
Externí odkaz:
https://doaj.org/article/b98174c0ab9448b282785b148dd6b082
Autor:
Wei-Yu Lin, Sarah E. Fordham, Nicola Sunter, Claire Elstob, Thahira Rahman, Elaine Willmore, Colin Shepherd, Gordon Strathdee, Tryfonia Mainou-Fowler, Rachel Piddock, Hannah Mearns, Timothy Barrow, Richard S. Houlston, Helen Marr, Jonathan Wallis, Geoffrey Summerfield, Scott Marshall, Andrew Pettitt, Christopher Pepper, Christopher Fegan, Francesco Forconi, Martin J. S. Dyer, Sandrine Jayne, April Sellors, Anna Schuh, Pauline Robbe, David Oscier, James Bailey, Syed Rais, Alison Bentley, Lynn Cawkwell, Paul Evans, Peter Hillmen, Guy Pratt, David J. Allsup, James M. Allan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
The clinical course of chronic lymphocytic leukaemia (CLL) is variable and difficult to predict. Here, the authors conduct a genome wide association study meta-analysis for time to first treatment in CLL patients and report two loci associating with
Externí odkaz:
https://doaj.org/article/326c1d18f1cc498d8b36824ed27e2e04
Autor:
Wei-Yu Lin, Sarah E. Fordham, Eric Hungate, Nicola J. Sunter, Claire Elstob, Yaobo Xu, Catherine Park, Anne Quante, Konstantin Strauch, Christian Gieger, Andrew Skol, Thahira Rahman, Lara Sucheston-Campbell, Junke Wang, Theresa Hahn, Alyssa I. Clay-Gilmour, Gail L. Jones, Helen J. Marr, Graham H. Jackson, Tobias Menne, Mathew Collin, Adam Ivey, Robert K. Hills, Alan K. Burnett, Nigel H. Russell, Jude Fitzgibbon, Richard A. Larson, Michelle M. Le Beau, Wendy Stock, Olaf Heidenreich, Abrar Alharbi, David J. Allsup, Richard S. Houlston, Jean Norden, Anne M. Dickinson, Elisabeth Douglas, Clare Lendrem, Ann K. Daly, Louise Palm, Kim Piechocki, Sally Jeffries, Martin Bornhäuser, Christoph Röllig, Heidi Altmann, Leo Ruhnke, Desiree Kunadt, Lisa Wagenführ, Heather J. Cordell, Rebecca Darlay, Mette K. Andersen, Maria C. Fontana, Giovanni Martinelli, Giovanni Marconi, Miguel A. Sanz, José Cervera, Inés Gómez-Seguí, Thomas Cluzeau, Chimène Moreilhon, Sophie Raynaud, Heinz Sill, Maria Teresa Voso, Francesco Lo-Coco, Hervé Dombret, Meyling Cheok, Claude Preudhomme, Rosemary E. Gale, David Linch, Julia Gaal-Wesinger, Andras Masszi, Daniel Nowak, Wolf-Karsten Hofmann, Amanda Gilkes, Kimmo Porkka, Jelena D. Milosevic Feenstra, Robert Kralovics, David Grimwade, Manja Meggendorfer, Torsten Haferlach, Szilvia Krizsán, Csaba Bödör, Friedrich Stölzel, Kenan Onel, James M. Allan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/1723b41ffb3e40a6be29fdc671afedd7
Autor:
Friedrich, Stölzel, Sarah E, Fordham, Devi, Nandana, Wei-Yu, Lin, Helen J, Blair, Claire J, Elstob, Hayden L, Bell, Brigitte, Mohr, Leo, Ruhnke, Desiree, Kunadt, Claudia, Dill, Daniel A, Allsop, Rachel E, Piddock, Emmanouela-Niki, Soura, Catherine Vida, Park, Mohd, Fadly, Thahira, Rahman, Abrar A, Alharbi, Manja, Wobus, Heidi, Altmann, Christoph, Röllig, Lisa, Wagenführ, Gail L, Jones, Tobias, Menne, Graham H, Jackson, Helen J, Marr, Jude, Fitzgibbon, Kenan, Onel, Manja, Meggendorfer, Amber, Robinson, Zuzanna, Bziuk, Emily, Bowes, Olaf, Heidenreich, Torsten, Haferlach, Sara, Villar, Beñat, Ariceta, Rosa, Ayala Diaz, Steven J, Altschuler, Lani, Wu, Felipe, Prosper, Pau, Montesinos, Joaquin, Martinez-Lopez, Martin, Bornhäuser, James M, Allan
Publikováno v:
JCI insight.
Precision medicine can significantly improve outcomes for cancer patients, but implementation requires comprehensive characterization of tumor cells to identify therapeutically exploitable vulnerabilities. Here we describe somatic biallelic TET2 muta
Autor:
Anne M. Dickinson, Gail Jones, David C. Linch, Clare Lendrem, David Grimwade, Richard A. Larson, Andrew D. Skol, Yaobo Xu, Adam Ivey, Wei-Yu Lin, Manja Meggendorfer, Rosemary E. Gale, Inés Gómez-Seguí, Giovani Marconi, Jean Norden, Jude Fitzgibbon, Mette K. Andersen, M Bornhäuser, Sarah E. Fordham, Amanda F. Gilkes, Heinz Sill, Eric A. Hungate, José Cervera, Friedrich Stölzel, Julia Gaal-Wesinger, Kim Piechocki, Wendy Stock, Theresa Hahn, Konstantin Strauch, David Allsup, Kenan Onel, Claire Elstob, Alyssa I. Clay-Gilmour, Nicola J. Sunter, Jelena D. Milosevic Feenstra, Meyling Cheok, Abrar Alharbi, Ann K. Daly, Sally Jeffries, Lisa Wagenführ, Olaf Heidenreich, Robert Kralovics, Alan K. Burnett, Giovanni Martinelli, Desiree Kunadt, Christian Gieger, Francesco Lo-Coco, Leo Ruhnke, Maria Teresa Voso, Junke Wang, Catherine Park, Nigel H. Russell, Chimène Moreilhon, Robert Kerrin Hills, Claude Preudhomme, Graham Jackson, Daniel Nowak, Maria Chiara Fontana, James M. Allan, Heidi Altmann, Richard S. Houlston, Anne S. Quante, Michelle M. Le Beau, Thahira Rahman, Christoph Röllig, Rebecca Darlay, Sophie Raynaud, Helen Marr, Csaba Bödör, Louise Palm, Thomas Cluzeau, Szilvia Krizsán, Heather J. Cordell, Mathew Collin, Torsten Haferlach, Lara E. Sucheston-Campbell, Wolf-Karsten Hofmann, Kimmo Porkka, Andras Masszi, Hervé Dombret, Miguel A. Sanz, Elisabeth Douglas, Tobias Menne
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Nat. Commun. 12:6233 (2021)
Nature Communications
Nat. Commun. 12:6233 (2021)
Nature Communications
Acute myeloid leukemia (AML) is a hematological malignancy with an undefined heritable risk. Here we perform a meta-analysis of three genome-wide association studies, with replication in a fourth study, incorporating a total of 4018 AML cases and 104
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66da5a2f677e98ca34ff7ab5930a5dd3
http://hdl.handle.net/10138/337099
http://hdl.handle.net/10138/337099
Autor:
Michelle M. Le Beau, Thahira Rahman, Yaobo Xu, Wendy Stock, Andrew D. Skol, Abrar Alharbi, David Allsup, Claire Elstob, Lara E. Sucheston-Campbell, Lisa Wagenführ, Olaf Heidenreich, Claude Preudhomme, Tobias Menne, Szilvia Krizsán, Rebecca Darlay, Jelena D. Milosevic Feenstra, David C. Linch, Sophie Raynaud, Helen Marr, Christian Gieger, Francesco Lo-Coco, David Grimwade, Maria Teresa Voso, Junke Wang, Christoph Röllig, Clare Lendrem, Wolf-Karsten Hofmann, Mathew Collin, Manja Meggendorfer, Friedrich Stölzel, Wei-Yu Lin, Ann K. Daly, Theresa Hahn, Torsten Haferlach, Sally Jeffries, Julia Gaal-Wesinger, Konstantin Strauch, Giovani Marconi, Amanda F. Gilkes, Chimène Moreilhon, Giovanni Martinelli, Anne M. Dickinson, Robert Kerrin Hills, Alan K. Burnett, Mette K. Andersen, Leo Ruhnke, Kimmo Porkka, Catherine Park, Desiree Kunadt, Nigel H. Russell, M Bornhäuser, Alyssa I. Clay-Gilmour, Hervé Dombret, Sarah E. Fordham, Eric A. Hungate, Miguel A. Sanz, Inés Gómez-Seguí, Csaba Bödör, Jean Norden, Elisabeth Douglas, Rosemary E. Gale, Heinz Sill, Kim Piechocki, Richard A. Larson, Robert Kralovics, Meyling Cheok, Heidi Altmann, Richard S. Houlston, Andras Masszi, Anne S. Quante, Louise Palm, Thomas Cluzeau, Heather J. Cordell, Nicola J. Sunter, Graham Jackson, Daniel Nowak, Maria Chiara Fontana, James M. Allan, José Cervera, Kenan Onel, Gail Jones, Adam Ivey, Jude Fitzgibbon
Acute myeloid leukemia (AML) is a hematological malignancy with an undefined heritable risk. Here we performed a meta-analysis of three genome-wide association studies, with replication in a fourth study, incorporating a total of 4018 AML cases and 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88c65e332ff115796663c5aed53834aa
https://doi.org/10.1101/2021.07.22.21259893
https://doi.org/10.1101/2021.07.22.21259893
Autor:
Rachel Piddock, Claire Elstob, Abrar Alharbi, Emmanouela-Niki Soura, Graham Jackson, Joaquin Martinez-Lopez, Gail Jones, Tobias Menne, Brigitte Mohr, James M. Allan, Desiree Kunadt, Helen J. Blair, Jude Fitzgibbon, Christoph Röllig, Heidi Altmann, Claudia Dill, Leo Ruhnke, Manja Meggendorfer, Lisa Wagenführ, Olaf Heidenreich, Helen Marr, Sarah E. Fordham, Thahira Rahman, Kenan Onel, Mohd Fadly, Martin Bornhäuser, Torsten Haferlach, Friedrich Stölzel, Beñat Ariceta, Pau Montesinos, Wei-Yu Lin, Felipe Prosper, Catherine Park, Rosa Ayala Diaz, Devi Nandana, Daniel Allsop, Sara Villar, Manja Wobus
Precision medicine can significantly improve outcomes for cancer patients, but implementation requires comprehensive characterization of tumor cells to identify therapeutically exploitable vulnerabilities. Here we describe somatic biallelic TET2 muta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bce312283fde11cc321c74be561c80ff
https://doi.org/10.1101/2021.07.14.21259597
https://doi.org/10.1101/2021.07.14.21259597
Autor:
Andrew R Harper, Bongani M Mayosi, Antony Rodriguez, Thahira Rahman, Darroch Hall, Chrysovalanto Mamasoula, Peter J Avery, Bernard D Keavney
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e55061 (2013)
Previous genome-wide linkage analysis has suggested that chromosomal region 17p13.3 may harbour genes influencing left ventricular mass (LVM) in man. To date, the genetic factors accounting for LVM variability remain largely unknown but a non-coding
Externí odkaz:
https://doaj.org/article/e03e75c43feb4ae096f9a9d58088f877
Autor:
Colin Shepherd, Nicola J. Sunter, Paul G. Evans, Rachel Piddock, David Allsup, Helen Marr, Scott Marshall, Claire Elstob, Francesco Forconi, Richard S. Houlston, Syed Ashar Rais, Tryfonia Mainou-Fowler, Thahira Rahman, April Sellors, Chris Pepper, Sandrine Jayne, Alison Bentley, Sarah E. Fordham, Christopher Fegan, Anna Schuh, Peter Hillmen, Martin J. S. Dyer, David Oscier, Wei-Yu Lin, James M. Allan, Lynn Cawkwell, Jonathan P. Wallis, Guy Pratt, James R. Bailey, Geoffrey Summerfield, Andrew R. Pettitt, Gordon Strathdee, Elaine Willmore, Hannah Mearns, Pauline Robbe, Timothy M. Barrow
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
Prognostication in patients with chronic lymphocytic leukemia (CLL) is challenging due to heterogeneity in clinical course. We hypothesize that constitutional genetic variation affects disease progression and could aid prognostication. Pooling data f