Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Thaher Pelaseyed"'
Autor:
Anandi Rajan, Pablo Gallego, Brendan Dolan, Piyush Patel, Chinmay Dwibedi, Ana S. Luis, Sergio Trillo-Muyo, Liisa Arike, Sjoerd van der Post, Magnus Simrén, Thaher Pelaseyed
Publikováno v:
Gut Microbes, Vol 16, Iss 1 (2024)
The anaerobic spirochete Brachyspira causes intestinal spirochetosis, characterized by the intimate attachment of bacterial cells to the colonic mucosa, potentially leading to symptoms such as diarrhea, abdominal pain, and weight loss. Despite the cl
Externí odkaz:
https://doaj.org/article/8912f417e26447cc988a1fa5ed44a469
Autor:
Tiange Lang, Thaher Pelaseyed
Publikováno v:
PLoS ONE, Vol 17, Iss 10 (2022)
Human tissue surfaces are coated with mucins, a family of macromolecular sugar-laden proteins serving diverse functions from lubrication to the formation of selective biochemical barriers against harmful microorganisms and molecules. Membrane mucins
Externí odkaz:
https://doaj.org/article/13ca232952274b11921e70e06e13abee
Autor:
Thaher Pelaseyed, Raghuvir Viswanatha, Cécile Sauvanet, Joshua J Filter, Michael L Goldberg, Anthony Bretscher
Publikováno v:
eLife, Vol 6 (2017)
How cells specify morphologically distinct plasma membrane domains is poorly understood. Prior work has shown that restriction of microvilli to the apical aspect of epithelial cells requires the localized activation of the membrane-F-actin linking pr
Externí odkaz:
https://doaj.org/article/0a19efe1dbe24174858d34927ed7ec10
Publikováno v:
bioRxiv
A dense glycocalyx, composed of the megaDalton-sized membrane mucin MUC17, coats the microvilli in the apical brush border of transporting intestinal epithelial cells, called enterocytes. The establishment of the MUC17-based glycocalyx in the mouse s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd8a6c47aab8c83e5484169a93caaaf7
https://europepmc.org/articles/PMC10028800/
https://europepmc.org/articles/PMC10028800/
Autor:
Thaher Pelaseyed, Tiange Lang
Publikováno v:
PloS one. 17(10)
Human tissue surfaces are coated with mucins, a family of macromolecular sugar-laden proteins serving diverse functions from lubrication to the formation of selective biochemical barriers against harmful microorganisms and molecules. Membrane mucins
Publikováno v:
Cell reports. 34(7)
The intestine is under constant exposure to chemicals, antigens, and microorganisms from the external environment. Apical aspects of transporting epithelial cells (enterocytes) form a brush-border membrane (BBM), shaped by packed microvilli coated wi
Autor:
Gunnar C. Hansson, Thaher Pelaseyed
Publikováno v:
J Cell Sci
Journal of Cell Science
Journal of Cell Science
Membrane mucins cover most mucosal surfaces throughout the human body. The intestine harbors complex population of microorganisms (the microbiota) and numerous exogenous molecules that can harm the epithelium. In the colon, where the microbial burden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c057a69f7f16c4ca968d3f2009bb4e7
https://europepmc.org/articles/PMC7075048/
https://europepmc.org/articles/PMC7075048/
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Scientific Reports
Scientific Reports
Mucins are highly glycosylated proteins which protect the epithelium. In the small intestine, the goblet cell-secreted Muc2 mucin constitutes the main component of the loose mucus layer that traps luminal material. The transmembrane mucin Muc17 forms
Publikováno v:
The Journal of Immunology. 206:17.13-17.13
The aim of this study is to determine the role of membrane mucin MUC17 in Crohn’s disease (CD). The incidence of CD is increasing in Western countries. However, the epithelial defects that cause disease are unclear. CD is characterized by the disru