Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Thaddeus S. Nowak"'
Publikováno v:
Stroke. 53
C57BL/6 mouse substrains of the N lineage derived from the NIH colony later than the separation of the Bailey line in the early 1960s show increased stroke vulnerability relative to C57BL/6J. A missense mutation in Cyfip2 , encoding cytoplasmic FMR1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::164da1c9fab2dc6102988e298e41f8a6
https://doi.org/10.1161/str.53.suppl_1.wp255
https://doi.org/10.1161/str.53.suppl_1.wp255
Autor:
Kathleen M. Kantak, Desmond J. Smith, M. Imad Damaj, Megan K. Mulligan, Hao Chen, Robert W. Williams, Camron D. Bryant, Thaddeus S. Nowak, Eva E. Redei
Publikováno v:
Trends in genetics : TIG, vol 36, iss 8
Trends Genet
Trends Genet
Genetically diverse inbred strains are frequently used in quantitative trait mapping to identify sequence variants underlying trait variation. Poor locus resolution and high genetic complexity impede variant discovery. As a solution, we explore reduc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8776d308ef2656157eccbd17cf6138a2
https://escholarship.org/uc/item/8ft0c6vm
https://escholarship.org/uc/item/8ft0c6vm
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 39:426-438
The C57BL/6 mouse strain is represented by distinct substrains, increasingly recognized to differ genetically and phenotypically. The current study compared stroke vulnerability among C57BL/6 J (J), C57BL/6JEiJ (JEiJ), C57BL/6ByJ (ByJ), C57BL/6NCrl (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::267b397b87dda08865bb7ea110c53946
https://doi.org/10.1177/0271678x17746174
https://doi.org/10.1177/0271678x17746174
Autor:
Megan K. Mulligan, Thaddeus S. Nowak
Publikováno v:
Neurochemistry international. 127
We have recently found significant variation in stroke vulnerability among substrains of C57BL/6 mice, observing that commonly used N-lineage substrains exhibit larger infarcts than C57BL/6J and related substrains. Parallel variation was also seen wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e0c24a202a023a194d971643b26085d
https://pubmed.ncbi.nlm.nih.gov/30448566
https://pubmed.ncbi.nlm.nih.gov/30448566
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 31:1863-1873
Peri-infarct depolarizations (PIDs) contribute to the evolution of focal ischemic lesions. Proposed mechanisms include both increased metabolic demand under conditions of attenuated perfusion and overt vasoconstrictive responses to depolarization. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aea86d789e5e3ef9ef0568f5bd23197
https://doi.org/10.1038/jcbfm.2011.62
https://doi.org/10.1038/jcbfm.2011.62
Autor:
Thaddeus S. Nowak, Jianfeng Xiao, Melissa Hines, Yu Zhao, Masayuki Ueda, Mark S. LeDoux, Yue Wang
Publikováno v:
Neuroscience. 155:439-453
DYT1 dystonia is caused by a single GAG deletion in exon 5 of TOR1A, the gene encoding torsinA, a putative chaperone protein. In this study, central and peripheral nervous system perturbations (transient forebrain ischemia and sciatic nerve transecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50c5ab0f619153ffe7ba5c4eb46b68df
https://doi.org/10.1016/j.neuroscience.2008.04.053
https://doi.org/10.1016/j.neuroscience.2008.04.053
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 27:1919-1930
The temperature threshold for protection by brief postischemic cooling was evaluated in a model of transient focal ischemia in the Spontaneously Hypertensive Rat, using an array of epidural probes to monitor regional brain temperatures. Rats were sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26b42dc3e364aa75d143eb92cb50f5c9
https://doi.org/10.1038/sj.jcbfm.9600492
https://doi.org/10.1038/sj.jcbfm.9600492
Publikováno v:
Neuroscience. 325
Anesthesia profoundly impacts peri-infarct depolarizations (PIDs), but only one prior report has described their monitoring during experimental stroke in awake animals. Since temporal patterns of PID occurrence are model specific, the current study e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74e12617248c307fa4b7d35200b6260c
https://pubmed.ncbi.nlm.nih.gov/27026594
https://pubmed.ncbi.nlm.nih.gov/27026594
Autor:
Thaddeus S. Nowak, Liang Zhao
The relationship between peri-infarct depolarizations (PIDs) and infarction was investigated in a model of preconditioning by cortical freeze lesions (cryogenic lesions, CL) in the Spontaneously Hypertensive Rat. Small (< 5 mm3) lesions produced 24 h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bca73c6a9703b58afef0b926ed9719f
https://europepmc.org/articles/PMC4640273/
https://europepmc.org/articles/PMC4640273/