Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Thaddeus J. Carlson"'
Autor:
Simon M. McHugh, Bill Davis, Liu He, Jackie Meakin, Paul A. Wilson, Sara Santos Franco, Thaddeus J. Carlson, Mercedes Lobera, Linda McCarthy, Justin P. Rubio, Sarah L. Spain, Rebecca E. McIntyre, Michael A. Nolan, Nicholas Galwey
Publikováno v:
PLoS ONE, Vol 16, Iss 10, p e0258316 (2021)
PLoS ONE
PLoS ONE, Vol 16, Iss 10 (2021)
PLoS ONE
PLoS ONE, Vol 16, Iss 10 (2021)
RORγt is an isoform of RORC, preferentially expressed in Th17 cells, that functions as a critical regulator of type 3 immunity. As murine Th17-driven inflammatory disease models were greatly diminished in RORC knock-out mice, this receptor was prior
Autor:
Lisa A. Orband-Miller, Erkan Baloglu, Jianfei Yang, Ashley A. Barnes, Jill Skepner, Thaddeus J. Carlson, Darby Schmidt, Mark S. Sundrud, Shomir Ghosh, Mercedes Lobera, Jonathan Hill, Radha Ramesh, Mohamed Boudjelal, Mark Trocha
Publikováno v:
The Journal of Immunology. 192:2564-2575
IL-17–producing CD4+Th17 cells, CD8+Tc17 cells, and γδ T cells play critical roles in the pathogenesis of autoimmune psoriasis. RORγt is required for the differentiation of Th17 cells and expression of IL-17. In this article, we describe a novel
Autor:
Anjana Rao, Alex Pellerin, Catherine Trivigno, Thaddeus J. Carlson, Mark S. Sundrud, Sergei B. Koralov, Ivana M. Djuretic
Publikováno v:
The Journal of Immunology. 192:2167-2176
The IL-23 pathway is genetically linked to autoimmune disease in humans and is required for pathogenic Th17 cell function in mice. However, because IL-23R–expressing mature Th17 cells are rare and poorly defined in mice at steady-state, little is k
Autor:
Derya Unutmaz, Lina Kozhaya, Jacob L. McCauley, Kelly McKevitt, Ivana M. Djuretic, Maria T. Abreu, Mark S. Sundrud, Radha Ramesh, Maria A. Quintero, Thaddeus J. Carlson
Publikováno v:
The Journal of Experimental Medicine
Inflammatory T helper 17 cells in humans are distinguished by selective expression of MDR1 and are enriched in the gut of patients with Crohn’s disease.
IL-17A–expressing CD4+ T cells (Th17 cells) are generally regarded as key effectors of a
IL-17A–expressing CD4+ T cells (Th17 cells) are generally regarded as key effectors of a
Autor:
Ivana M. Djuretic, Thaddeus J. Carlson, Derya Unutmaz, Qi Wan, Lina Kozhaya, Mark S. Sundrud, Aimee ElHed, Radha Ramesh
Publikováno v:
The Journal of Experimental Medicine
PI-3K–mediated repression of FOXO1 and KLF2 promotes proinflammatory cytokine expression by lineage-committed human CCR6+ Th17/Th22 memory cells.
Human memory T cells (TM cells) that produce IL-17 or IL-22 are currently defined as Th17 or Th22
Human memory T cells (TM cells) that produce IL-17 or IL-22 are currently defined as Th17 or Th22
Publikováno v:
Journal of Experimental Medicine. 205:1535-1541
The interleukin (IL)-12p40 family of cytokines plays a critical role in the development of experimental autoimmune encephalomyelitis (EAE). However, the relative contributions of IL-12 and IL-23 to the pathogenic process remain to be elucidated. Here
Publikováno v:
The Journal of experimental medicine, vol 205, iss 4
The Journal of Experimental Medicine
The Journal of Experimental Medicine
The ELR+ CXC chemokines CXCL1 and CXCL2 are up-regulated in the central nervous system (CNS) during multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). However, their functional significance and the pathways
In vivo regulation of gene expression and T helper type 17 differentiation by RORγt inverse agonists
Autor:
Jill Skepner, Erkan Baloglu, Jonathan Hill, Mark Trocha, Mark S. Sundrud, Xiaoyan Qu, Michael A. Nolan, Radha Ramesh, Jianfei Yang, Scott Davis, Shomir Ghosh, Thaddeus J. Carlson, Darby Schmidt, Mercedes Lobera
Publikováno v:
Immunology. 145(3)
The orphan nuclear receptor, retinoic acid receptor-related orphan nuclear receptor γt (RORγt), is required for the development and pathogenic function of interleukin-17A-secreting CD4(+) T helper type 17 (Th17) cells. Whereas small molecule RORγt
Autor:
Sarah B. Matousek, Thaddeus J. Carlson, M. Kerry O'Banion, Stephanos Kyrkanides, John A. Olschowka, Solomon S. Shaftel
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 27(35)
The proinflammatory cytokine interleukin-1β (IL-1β) plays a significant role in leukocyte recruitment to the CNS. Although acute effects of IL-1β signaling in the mouse brain have been well described, studies elucidating the downstream effects of
Publikováno v:
The FASEB Journal. 22:456-456