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Evidence for a novel, effective approach to targeting carcinoma catabolism exploiting the first-in-class, anti-cancer mitochondrial drug, CPI-613.

Autor: Guardado Rivas, Moises O., Stuart, Shawn D., Thach, Daniel, Dahan, Michael, Shorr, Robert, Zachar, Zuzana, Bingham, Paul M.

Publikováno v: PLoS ONE; 6/8/2022, Vol. 17 Issue 6, p1-30, 30p

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APR-246 increases tumor antigenicity independent of p53.

Autor: Michels J; Department of Pharmacology, Swim Across America and Ludwig Collaborative Laboratory, Weill Cornell Medicine, New York, NY, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Venkatesh D; Department of Pharmacology, Swim Across America and Ludwig Collaborative Laboratory, Weill Cornell Medicine, New York, NY, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Liu C; Department of Pharmacology, Swim Across America and Ludwig Collaborative Laboratory, Weill Cornell Medicine, New York, NY, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Budhu S; Department of Pharmacology, Swim Across America and Ludwig Collaborative Laboratory, Weill Cornell Medicine, New York, NY, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Zhong H; Department of Pharmacology, Swim Across America and Ludwig Collaborative Laboratory, Weill Cornell Medicine, New York, NY, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., George MM; Department of Pharmacology, Swim Across America and Ludwig Collaborative Laboratory, Weill Cornell Medicine, New York, NY, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Thach D; Department of Pharmacology, Swim Across America and Ludwig Collaborative Laboratory, Weill Cornell Medicine, New York, NY, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Yao ZK; The Organic Synthesis Core Facility, MSK, New York, NY, USA., Ouerfelli O; The Organic Synthesis Core Facility, MSK, New York, NY, USA., Liu H; Department of Biological Sciences, Columbia University, New York, NY, USA., Stockwell BR; Department of Biological Sciences, Columbia University, New York, NY, USA.; Department of Chemistry, Columbia University, New York, NY, USA., Campesato LF; Department of Pharmacology, Swim Across America and Ludwig Collaborative Laboratory, Weill Cornell Medicine, New York, NY, USA.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA., Zamarin D; Swim Across America and Ludwig Collaborative Laboratory, Immunology Program, Parker Institute for Cancer Immunotherapy, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Immuno-Oncology Service, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Zappasodi R; Department of Medicine, Weill Cornell, New York, NY, USA., Wolchok JD; Department of Pharmacology, Swim Across America and Ludwig Collaborative Laboratory, Weill Cornell Medicine, New York, NY, USA jwolchok@med.cornell.edu.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.; Department of Medicine, Weill Cornell, New York, NY, USA., Merghoub T; Department of Pharmacology, Swim Across America and Ludwig Collaborative Laboratory, Weill Cornell Medicine, New York, NY, USA tmerghoub@med.cornell.edu.; Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA.; Department of Medicine, Weill Cornell, New York, NY, USA.

Publikováno v: Life science alliance [Life Sci Alliance] 2023 Oct 27; Vol. 7 (1). Date of Electronic Publication: 2023 Oct 27 (Print Publication: 2024).