Endocytosis and Exocytosis in Leishmania amazonensis Are Modulated by Bromoenol Lactone

Autor: Anne C. S. Fernandes, Deivid C. Soares, Roberta F. C. Neves, Carolina M. Koeller, Norton Heise, Camila M. Adade, Susana Frases, José R. Meyer-Fernandes, Elvira M. Saraiva, Thaïs Souto-Padrón

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)

In the protozoan pathogen Leishmania, endocytosis, and exocytosis occur mainly in the small area of the flagellar pocket membrane, which makes this parasite an interesting model of strikingly polarized internalization and secretion. Moreover, little

Externí odkaz: https://doaj.org/article/2e482428e7c54160acc85c2b2dd09cc3

Crovirin, a snake venom cysteine-rich secretory protein (CRISP) with promising activity against Trypanosomes and Leishmania.

Autor: Camila M Adade, Ana Lúcia O Carvalho, Marcelo A Tomaz, Tatiana F R Costa, Joseane L Godinho, Paulo A Melo, Ana Paula C A Lima, Juliany C F Rodrigues, Russolina B Zingali, Thaïs Souto-Padrón

Publikováno v: PLoS Neglected Tropical Diseases, Vol 8, Iss 10, p e3252 (2014)

The neglected human diseases caused by trypanosomatids are currently treated with toxic therapy with limited efficacy. In search for novel anti-trypanosomatid agents, we showed previously that the Crotalus viridis viridis (Cvv) snake venom was active

Externí odkaz: https://doaj.org/article/69b73468c4d8432d978a2b1dd6e6a875

The calpain inhibitor MDL28170 induces the expression of apoptotic markers in Leishmania amazonensis promastigotes.

Autor: Fernanda A Marinho, Keyla C S Gonçalves, Simone S C Oliveira, Diego S Gonçalves, Filipe P Matteoli, Sergio H Seabra, Ana Carolina S Oliveira, Maria Bellio, Selma S Oliveira, Thaïs Souto-Padrón, Claudia M d'Avila-Levy, André L S Santos, Marta H Branquinha

Publikováno v: PLoS ONE, Vol 9, Iss 1, p e87659 (2014)

Human cutaneous leishmaniasis is caused by distinct species, including Leishmania amazonensis. Treatment of cutaneous leishmaniasis is far from satisfactory due to increases in drug resistance and relapses, and toxicity of compounds to the host. As a

Externí odkaz: https://doaj.org/article/9c7bdc12e1df4bd9abdf9e753b3afd5d

Lopinavir and Nelfinavir Induce the Accumulation of Crystalloid Lipid Inclusions within the Reservosomes of Trypanosoma cruzi and Inhibit Both Aspartyl-Type Peptidase and Cruzipain Activities Detected in These Crucial Organelles

Autor: André L.S. Santos, Marta H. Branquinha, Miria G. Pereira, Thaïs Souto-Padrón, Leandro S. Sangenito

Publikováno v: Tropical Medicine and Infectious Disease, Vol 6, Iss 120, p 120 (2021)
Tropical Medicine and Infectious Disease; Volume 6; Issue 3; Pages: 120
Tropical Medicine and Infectious Disease

Several research groups have explored the repositioning of human immunodeficiency virus aspartyl peptidase inhibitors (HIV-PIs) on opportunistic infections caused by bacteria, fungi and protozoa. In Trypanosoma cruzi, HIV-PIs have a high impact on pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0e274e097d1c7f843947426db6f52f3
https://www.mdpi.com/2414-6366/6/3/120

Thein vitroantileishmanial activity of essential oil fromAloysia gratissimaand guaiol, its major sesquiterpene againstLeishmania amazonensis

Autor: Deivid Costa Soares, Antonio Carlos Siani, Maria das Graças Miranda Danelli, Elvira M. Saraiva, Raissa Couto Santana, Lucia H. Pinto-da-Silva, M.C.F. Garcia, Thaïs Souto-Padrón, Mônica Freiman de Souza Ramos

Publikováno v: Parasitology. 145:1219-1227

Leishmaniases is a tropical disease caused by protozoa of the genusLeishmaniafor which the current treatment is expensive, besides increasing reports of parasite resistance. This study investigated the anti-Leishmania amazonensisactivity of the essen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21c9d470ff976cb00f14a5a1a0023991
https://doi.org/10.1017/s0031182017002335