Výsledky vyhledávání - "Th2 Cells/metabolism"

Double Positive CD4+CD8+ T Cells Are Enriched in Urological Cancers and Favor T Helper-2 Polarization

Autor: Denise Nardelli-Haefliger, Ilaria Lucca, Massimo Valerio, Patrice Jichlinski, Sonia-Christina Rodrigues-Dias, Laurent Derré, Rodolfo Burruni, Florence Dartiguenave, Thomas Tawadros, Valérie Cesson, Perrine Bohner, Mathieu F. Chevalier

Publikováno v: Frontiers in Immunology
Frontiers in Immunology, Frontiers, 2019, 10, ⟨10.3389/fimmu.2019.00622⟩
Frontiers in Immunology, Vol 10 (2019)
Frontiers in immunology, vol. 10, pp. 622

The immune system plays a central role in cancer development, showing both anti-tumor and pro-tumor activities depending on the immune cell subsets and the disease context. While CD8 T cells are associated with a favorable outcome in most cancers, on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f34716cc65e1b6de45583df3a05f67e
https://hal.archives-ouvertes.fr/hal-03031633/document

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A recessive form of hyper-IgE syndrome by disruption of ZNF341-dependent STAT3 transcription and activity

Autor: Warren J. Leonard, Nima Rezaei, Kathryn Payne, Isabelle Meyts, Laurent Abel, Cindy S. Ma, Marianne Leruez-Ville, Janet Chou, Alain Hovnanian, Jian-Xin Lin, Simon J. Pelham, Danielle T. Avery, Matthieu Bouaziz, Bethany Pillay, Tanwir Habib, Anne Puel, Sevgi Keles, Juan Li, Isabelle Pellier, Jamel El-Benna, Bernhard Fleckenstein, Ahmet Ozen, Vivien Béziat, Ingrid Müller-Fleckenstein, Damien Chaussabel, Samaneh Zoghi, Yi Wang, Paul Gray, Matthias Titeux, Yoann Zerbib, Talal A. Chatila, Marie-Alexandra Alyanakian, Capucine Picard, Orli Wargon, Ayper Somer, Marie-Olivia Chandesris, Thibaut Leclercq, Ibtihal Benhsaien, Aziz Belkadi, Jean-Laurent Casanova, Romain Lévy, Peng Li, Geetha Rao, Ai Ing Lim, James P. Di Santo, Nico Marr, Sylvie Fraitag, Frédégonde About, Elissa K. Deenick, Bertrand Boisson, Jacinta Bustamante, Mélanie Migaud, Bodo Grimbacher, Aziz Bousfiha, Fatima Ailal, Safa Baris, Antoine Guérin, Stuart G. Tangye, Romain Guery, Ning Du, Vimel Rattina

Publikováno v: Science Immunology
Science Immunology, American Association for the Advancement of Science, 2018, 3 (24), pp.eaat4956. ⟨10.1126/sciimmunol.aat4956⟩
Science Immunology, 2018, 3 (24), pp.eaat4956. ⟨10.1126/sciimmunol.aat4956⟩

Comment in :Who regulates whom: ZNF341 is an additional player in the STAT3/TH17 song. [Sci Immunol. 2018]; International audience; Heterozygosity for human signal transducer and activator of transcription 3 (STAT3) dominant-negative (DN) mutations u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a014e03bf19bbdfb4eb205a53e190a3a
https://doi.org/10.1126/sciimmunol.aat4956

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Bystander immunotherapy as a strategy to control allergen-driven airway inflammation

Autor: Sébastien Fleury, Severine Navarro, Nicolas Glaichenhaus, A Kanda, David Dombrowicz, Anne Lazzari, Valérie Julia

Publikováno v: Mucosal Immunology
Mucosal Immunology, Nature Pub. Group, 2015, 8 (4), pp.841-851. ⟨10.1038/mi.2014.115⟩
Mucosal Immunology, 2015, 8 (4), pp.841-851. ⟨10.1038/mi.2014.115⟩

International audience; Allergic asthma is a chronic inflammatory disease characterized by airway hyperresponsiveness (AHR), lung infiltration of Th2 cells, and high levels of IgE. To date, allergen-specific immunotherapy (SIT) is the only treatment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1d213c53e8f68090bfc11e41706a54b
https://doi.org/10.1038/mi.2014.115

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MPLA shows attenuated pro-inflammatory properties and diminished capacity to activate mast cells in comparison with LPS

Autor: Isabelle Angers, Stephen J. Galli, Adam Flaczyk, Salman T. Qureshi, Lothar Vogel, Ingo Spreitzer, Nicolas Gaudenzio, Sonja Wolfheimer, Stefan Schülke, B. Löschner, Mindy Tsai, Stephan Scheurer, Stefan Vieths

Publikováno v: Allergy
Allergy, Wiley, 2015, 70 (10), pp.1259-1268. ⟨10.1111/all.12675⟩

Background Monophosphoryl lipid A (MPLA), a nontoxic TLR4 ligand derived from lipopolysaccharide (LPS), is used clinically as an adjuvant in cancer, hepatitis, and malaria vaccines and in allergen-specific immunotherapy. Nevertheless, its cell-activa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ead28381c905416c0cb2ec75c2a88011
https://pubmed.ncbi.nlm.nih.gov/26081583

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Role of Tyk-2 in Th9 and Th17 cells in allergic asthma

Autor: Übel, Caroline, Graser, Anna, Koch, Sonja, Rieker, Ralf J., Lehr, Hans A., Müller, Mathias, Finotto, Susetta

Publikováno v: Scientific Reports
Scientific reports, vol. 4, pp. 5865

In a murine model of allergic asthma, we found that Tyk-2((-/-)) asthmatic mice have induced peribronchial collagen deposition, mucosal type mast cells in the lung, IRF4 and hyperproliferative lung Th2 CD4(+) effector T cells over-expressing IL-3, IL

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::449d9a72dc831f2aea32846f2e8118b9
https://pubmed.ncbi.nlm.nih.gov/25109392

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Cytokine production by T-cell clones from bronchoalveolar lavage fluid of patients with asthma and healthy subjects

Publikováno v: European respiratory journal. Supplement. 22:95s-103s

Cytokines produced by T-lymphocytes play an important regulatory role in inflammation in the airways of asthmatic patients. Our aim was to analyse the cytokine production by T-cell clones from bronchoalveolar lavage fluid (BAL) of patients with aller

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dris___00893::0b3c3aeea21059f91e46e4bbd169882f

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OatA, a Peptidoglycan O-Acetyltransferase Involved in Listeria monocytogenes Immune Escape, Is Critical for Virulence

Autor: Martin Sachse, Pascale Cossart, Olivier Dussurget, Jérémie Decalf, Céline Goulard, Ivo G. Boneca, Camille Aubry, Marie-Anne Nahori, Nadège Cayet

Publikováno v: Journal of Infectious Diseases
Journal of Infectious Diseases, Oxford University Press (OUP), 2011, 204 (5), pp.731-40. ⟨10.1093/infdis/jir396⟩
Journal of Infectious Diseases, 2011, 204 (5), pp.731-40. ⟨10.1093/infdis/jir396⟩

International audience; Microbial pathogens have evolved mechanisms to overcome immune responses and successfully infect their host. Here, we studied how Listeria monocytogenes evades immune detection by peptidoglycan (PGN) modification. By analyzing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::573d739a76a1398c4216968d8b7f03f4
https://hal-pasteur.archives-ouvertes.fr/pasteur-01402076

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Critical influence of natural regulatory CD25+ T cells on the fate of allografts in the absence of immunosuppression

Autor: Alain Le Moine, Luis Graca, Fleur Samantha Benghiat, Sophie Detienne, Michel Goldman, Fabrice Moore, Herman Waldmann, Véronique Flamand, Michel Y Braun, Sofia Buonocore

Publikováno v: Transplantation, 79 (6

BACKGROUND: Allografts are occasionally accepted in the absence of immunosuppression. Because naturally occurring CD4(+)CD25(+) regulatory T cells (natural CD25(+) Treg cells) have been shown to inhibit allograft rejection, we investigated their infl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dbd4aa3b035c17602e1a04aee19acbb
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/50334

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Acute rejection in the absence of cognate recognition of allograft by T cells

Autor: Braun, M. Y., Grandjean, I., Feunou, P., Duban, L., Kiss, R., Goldman, M., olivier Lantz

Publikováno v: The Journal of immunology, 166 (8
Scopus-Elsevier

We studied the effects of the indirect pathway of allograft recognition using T cells from TCR transgenic Marilyn mice, which recognize the male Ag H-Y in an I-A(b)-restricted fashion. The T cells are not alloreactive to the H-2(k) haplotype, because

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::d0d5c00b7c85bd5cfd2e841822d8fb16
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/50340

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