Výsledky vyhledávání - "Th.J.C. van Berkel"

Attenuated atherosclerosis upon IL-17R signaling disruption in LDLr deficient mice

Autor: W.B. van den Berg, I.M. Michon, G.H.M. van Puijvelde, Th.J.C. van Berkel, Johan Kuiper, O.H. Ramos, P. de Vos, T. van Es, Leo A. B. Joosten, Filip M. Segers

Publikováno v: Biochemical and Biophysical Research Communications, 388, 2, pp. 261-5
Biochemical and Biophysical Research Communications, 388, 261-5

Contains fulltext : 80313.pdf (Publisher’s version ) (Closed access) Atherosclerosis is an inflammatory disease characterized by the influx of macrophages and T cells and IL-17 may connect innate and adaptive immune responses involved in atherogene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53018d6d00e09a737c9370fdfb72564c
https://doi.org/10.1016/j.bbrc.2009.07.152

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Leukocyte cathepsin S is a potent regulator of both cell and matrix turnover in advanced atherosclerosis

Autor: E. E. van der Wall, Th.J.C. van Berkel, R de Nooijer, P.J. van Santbrink, R. Dorland, Marijke M. Westra, Guo-Ping Shi, J.H. von der Thüsen, E.A.L. Biessen, Herman S. Overkleeft, A.O. Kraaijeveld, S.H. van Heiningen, Michiel A. Leeuwenburgh, Joop Jukema, Petri T. Kovanen, Ilze Bot

Publikováno v: Arteriosclerosis, thrombosis, and vascular biology, 29(2), 188-194. Lippincott Williams and Wilkins
Arteriosclerosis, thrombosis and vascular biology, 29(2), 188-194. Lippincott Williams & Wilkins

Objective— A dysbalance of proteases and their inhibitors is instrumental in remodeling of atherosclerotic plaques. One of the proteases implicated in matrix degradation is cathepsin-S (CatS). To address its role in advanced lesion composition, we

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1cfdd062ab4c67cd41bb96da9d0d7f9
https://doi.org/10.1161/atvbaha.108.181578

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Delivery of Chlamydia pneumoniae to the vessel wall aggravates atherosclerosis in LDLr-/- mice

Autor: P. de Vos, Th.J.C. van Berkel, Niels Peterse, H. ten Cate, Arnaud D. Hauer, Frank R. M. Stassen, Johan Kuiper

Publikováno v: Cardiovascular Research. 69:280-288

Objective: The role of Chlamydia pneumoniae in atherosclerosis is still debated. In this study a novel mouse model was applied to determine the direct impact of C. pneumoniae on the arterial wall and the development of atherosclerosis. Methods: Direc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8c22e83ffff7d32de001609e14100bf
https://doi.org/10.1016/j.cardiores.2005.07.011

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Genetic manipulation of macrophage—and vascular genes in mouse models of atherosclerosis

Autor: E.A.L. Biessen, M. Van Eck, Th.J.C. van Berkel, J.H. von der Thüsen, Johan Kuiper

Publikováno v: International Congress Series. 1262:384-387

Macrophage-derived foam cells play an essential role in the development of atherosclerosis. The population of macrophages in the arterial wall highly depends on monocyte infiltration from the blood circulation. Transplantation of the hematopoietic sy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::08131fa5e2c045c349341504f2cbd940
https://doi.org/10.1016/j.ics.2003.12.047

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Characterization of the Binding of Urokinase-Type Plasminogen Activator to the Asialoglycoprotein Receptor

Autor: E. Groeneveld, Johan Kuiper, Th.J.C. van Berkel, M.E. van der Kaaden, M.M. Barrett-Bergshoeff, Dingeman C. Rijken

Publikováno v: Thrombosis and Haemostasis. 88:83-88

SummaryIn order to study the role of the asialoglycoprotein receptor (ASGPr) in the rapid plasma clearance of urokinase-type plasminogen activator (u-PA), a microtiter plate binding assay was developed using ASGPr purified from rat liver extracts. Ur

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https://doi.org/10.1055/s-0037-1613158

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Effect of dietary elaidic versus vaccenic acid on blood and liver lipids in the hamster

Autor: Th.J.C. van Berkel, G. W. Meijer, A. van Tol, J.A. Weststrate

Publikováno v: Atherosclerosis, 157, 31-40. Elsevier Ireland Ltd

Male hamsters (30 per group) were fed five different semi-purified diets ad libitum. The diets, containing 30% of energy (en%) as fat, differed in their dietary fat composition (specified fatty acids exchanged at 10 en%) and were fed for 4 weeks. The

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https://doi.org/10.1016/s0021-9150(00)00661-4

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Drug targeting: application of endogenous carriers for site-specific delivery of drugs

Autor: Th.J.C. van Berkel

Publikováno v: Journal of Controlled Release. 24:145-155

Lipoproteins are endogenous particulate carriers responsible for the transport of cholesterol and other lipids in the blood circulation. Structurally, they consist of an apolar core, composed of triglycerides and/or cholesteryl esters, surrounded by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3c03ffe5071bd8b960b5a7b5fade43dd
https://doi.org/10.1016/0168-3659(93)90174-4

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Receptor-mediated endocytosis of tissue-type plasminogen activator (t-PA) by liver cells

Autor: Th.J.C. van Berkel, M. Otter, Johan Kuiper, Dingeman C. Rijken

Publikováno v: Thrombosis Research. 57:63-71

Tissue-type plasminogen activator (t-PA) has a short half-life in the circulation because the enzyme is rapidly cleared by the liver. This short review summarizes recent literature concerning mechanisms of uptake and degradation of t-PA in the liver.

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https://doi.org/10.1016/0049-3848(90)90379-q

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