Pharmacological Improvement of Cystic Fibrosis Transmembrane Conductance Regulator Function Rescues Airway Epithelial Homeostasis and Host Defense in Children with Cystic Fibrosis.

Autor: Loske J; Center of Digital Health, Molecular Epidemiology Unit, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.; Department of Biology and., Völler M; Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Lukassen S; Center of Digital Health, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany., Stahl M; Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.; German Center for Lung Research, Associated Partner Site, Berlin, Germany., Thürmann L; Center of Digital Health, Molecular Epidemiology Unit, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany., Seegebarth A; Center of Digital Health, Molecular Epidemiology Unit, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany., Röhmel J; Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.; German Center for Lung Research, Associated Partner Site, Berlin, Germany., Wisniewski S; Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany., Messingschlager M; Center of Digital Health, Molecular Epidemiology Unit, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.; Department of Biology and., Lorenz S; Max Planck Institute for Molecular Genetics, Berlin, Germany., Klages S; Max Planck Institute for Molecular Genetics, Berlin, Germany., Eils R; Department of Mathematics and Computer Science, Freie Universität Berlin, Berlin, Germany.; Center of Digital Health, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.; German Center for Lung Research, Associated Partner Site, Berlin, Germany.; Health Data Science Unit, BioQuant, Medical Faculty, University of Heidelberg, Heidelberg, Germany., Lehmann I; Center of Digital Health, Molecular Epidemiology Unit, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.; German Center for Lung Research, Associated Partner Site, Berlin, Germany., Mall MA; Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.; German Center for Lung Research, Associated Partner Site, Berlin, Germany., Graeber SY; Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.; German Center for Lung Research, Associated Partner Site, Berlin, Germany., Trump S; Center of Digital Health, Molecular Epidemiology Unit, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.

Publikováno v: American journal of respiratory and critical care medicine [Am J Respir Crit Care Med] 2024 Jun 01; Vol. 209 (11), pp. 1338-1350.

Global hypomethylation in childhood asthma identified by genome-wide DNA-methylation sequencing preferentially affects enhancer regions.

Autor: Thürmann L; Associated Member of the German Center for Lung Research, Unit for Molecular Epidemiology, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany., Klös M; Associated Member of the German Center for Lung Research, Unit for Molecular Epidemiology, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany., Mackowiak SD; Associated Member of the German Center for Lung Research, Center for Digital Health, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany., Bieg M; Associated Member of the German Center for Lung Research, Center for Digital Health, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany., Bauer T; German Cancer Research Center (DKFZ), Division of Theoretical Bioinformatics and Heidelberg Center for Personalized Oncology (DKFZ-HIPO), Heidelberg, Germany., Ishaque N; Associated Member of the German Center for Lung Research, Center for Digital Health, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany., Messingschlager M; Associated Member of the German Center for Lung Research, Unit for Molecular Epidemiology, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany., Herrmann C; Health Data Science Unit, Heidelberg University Hospital, Heidelberg, Germany., Röder S; Department of Environmental Immunology, Helmholtz Centre for Environmental Research (UFZ), Leipzig, Germany., Bauer M; Department of Environmental Immunology, Helmholtz Centre for Environmental Research (UFZ), Leipzig, Germany., Schäuble S; Friedrich-Schiller-University Jena, Jena University Language & Information Engineering (JULIE) Lab, Jena, Germany.; Leibniz Institute for Natural Product Research and Infection Biology-Hans Knöll Institute, Systems Biology and Bioinformatics Unit, Jena, Germany., Faessler E; Friedrich-Schiller-University Jena, Jena University Language & Information Engineering (JULIE) Lab, Jena, Germany., Hahn U; Friedrich-Schiller-University Jena, Jena University Language & Information Engineering (JULIE) Lab, Jena, Germany., Weichenhan D; Division of Cancer Epigenetics, German Cancer Research Center (DKFZ), Heidelberg, Germany., Mücke O; Division of Cancer Epigenetics, German Cancer Research Center (DKFZ), Heidelberg, Germany., Plass C; Division of Cancer Epigenetics, German Cancer Research Center (DKFZ), Heidelberg, Germany.; German Center for Lung Research (DZL), Heidelberg, Munich, Germany., Borte M; Children's Hospital, Municipal Hospital 'St. Georg', Leipzig, Germany., von Mutius E; German Center for Lung Research (DZL), Heidelberg, Munich, Germany.; Dr. von Hauner Children's Hospital, Ludwig Maximilian University Munich, Munich, Germany.; Helmholtz Zentrum München-German Research Center for Environmental Health, Institute for Asthma and Allergy Prevention, Neuherberg, Germany., Stangl GI; Martin Luther University Halle-Wittenberg, Institute of Agricultural and Nutritional Sciences, Halle (Saale), Germany., Lauener R; Children's Hospital of Eastern Switzerland, St. Gallen, Switzerland., Karvonen AM; Department of Health Security, Finnish Institute for Health and Welfare, Kuopio, Finland., Divaret-Chauveau A; Pediatric Allergy Department, Children's Hospital, University Hospital of Nancy, Vandoeuvre les Nancy, France.; UMR 6249 Chrono-Environment, Centre National de la Recherche Scientifique and University of Franche-Comté, Besançon, France.; EA3450 Development, Adaptation and Handicap, University of Lorraine, Nancy, France., Riedler J; Children's Hospital, Schwarzach, Austria., Heinrich J; German Center for Lung Research (DZL), Heidelberg, Munich, Germany.; Institute and Clinic for Occupational, Social and Environmental Medicine, University Hospital, LMU, Munich, Germany.; Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany., Standl M; German Center for Lung Research (DZL), Heidelberg, Munich, Germany.; Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany., von Berg A; Department of Pediatrics, Research Institute, Marien-Hospital Wesel, Wesel, Germany., Schaaf B; Pediatric Outpatient Department, Bad Honnef, Germany., Herberth G; Department of Environmental Immunology, Helmholtz Centre for Environmental Research (UFZ), Leipzig, Germany., Kabesch M; Department of Pediatric Pneumology and Allergy, University Children's Hospital Regensburg (KUNO), Regensburg, Germany., Eils R; Associated Member of the German Center for Lung Research, Center for Digital Health, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.; Health Data Science Unit, Heidelberg University Hospital, Heidelberg, Germany.; German Center for Lung Research (DZL), Heidelberg, Munich, Germany., Trump S; Associated Member of the German Center for Lung Research, Unit for Molecular Epidemiology, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany., Lehmann I; Associated Member of the German Center for Lung Research, Unit for Molecular Epidemiology, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.; German Center for Lung Research (DZL), Heidelberg, Munich, Germany.

Publikováno v: Allergy [Allergy] 2023 Jun; Vol. 78 (6), pp. 1489-1506. Date of Electronic Publication: 2023 Feb 10.

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Effects of exposure to single and multiple parabens on asthma development in an experimental mouse model and a prospective cohort study.

Autor: Junge KM; Helmholtz Centre for Environmental Research - UFZ, Department of Environmental Immunology, Leipzig, Germany; Institute of Agriculture and Nutritional Sciences, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany., Buchenauer L; Helmholtz Centre for Environmental Research - UFZ, Department of Environmental Immunology, Leipzig, Germany; Department of Dermatology, Venerology and Allergology, Leipzig University Medical Center, University of Leipzig, Leipzig, Germany., Strunz S; Helmholtz Centre for Environmental Research - UFZ, Department of Environmental Immunology, Leipzig, Germany; Department of Dermatology, Venerology and Allergology, Leipzig University Medical Center, University of Leipzig, Leipzig, Germany., Seiwert B; Helmholtz Centre for Environmental Research - UFZ, Department for Analytical Chemistry, Leipzig, Germany., Thürmann L; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Molecular Epidemiology, Berlin, Germany., Rolle-Kampczyk UE; Helmholtz Centre for Environmental Research - UFZ, Department of Molecular Systems Biology, Leipzig, Germany., Röder S; Helmholtz Centre for Environmental Research - UFZ, Department of Environmental Immunology, Leipzig, Germany., Borte M; Children's Hospital, Municipal Hospital 'St. Georg', Leipzig, Germany., Kiess W; University of Leipzig, Hospital for Children and Adolescents - Centre for Pediatric Research, Leipzig, Germany; University of Leipzig, LIFE - Leipzig Research Centre for Civilization Diseases, Leipzig, Germany., von Bergen M; Helmholtz Centre for Environmental Research - UFZ, Department of Molecular Systems Biology, Leipzig, Germany; University of Leipzig, Faculty of Life Sciences, Institute of Biochemistry, Leipzig, Germany., Simon JC; Department of Dermatology, Venerology and Allergology, Leipzig University Medical Center, University of Leipzig, Leipzig, Germany., Zenclussen AC; Helmholtz Centre for Environmental Research - UFZ, Department of Environmental Immunology, Leipzig, Germany., Schöneberg T; University of Leipzig, Medical Faculty, Rudolf Schönheimer Institute of Biochemistry, Leipzig, Germany., Stangl GI; Institute of Agriculture and Nutritional Sciences, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany., Herberth G; Helmholtz Centre for Environmental Research - UFZ, Department of Environmental Immunology, Leipzig, Germany., Lehmann I; Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Molecular Epidemiology, Berlin, Germany; German Center for Lung Research (DZL), associated partner, Berlin, Germany., Reemtsma T; Helmholtz Centre for Environmental Research - UFZ, Department for Analytical Chemistry, Leipzig, Germany., Polte T; Helmholtz Centre for Environmental Research - UFZ, Department of Environmental Immunology, Leipzig, Germany; Department of Dermatology, Venerology and Allergology, Leipzig University Medical Center, University of Leipzig, Leipzig, Germany. Electronic address: tobias.polte@ufz.de.

Publikováno v: The Science of the total environment [Sci Total Environ] 2022 Mar 25; Vol. 814, pp. 152676. Date of Electronic Publication: 2021 Dec 30.

Hypertension delays viral clearance and exacerbates airway hyperinflammation in patients with COVID-19.

Autor: Trump S; Molecular Epidemiology Unit, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Berlin, Germany., Lukassen S; Center for Digital Health, Berlin Institute of Health (BIH) and Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany., Anker MS; Department of Cardiology, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Berlin, Germany.; Division of Cardiology and Metabolism, Department of Cardiology Campus Virchow, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Berlin, Germany.; Centre for Cardiovascular Research (DZHK), Berlin, Germany.; Berlin Institute of Health Center for Regenerative Therapies (BCRT), Berlin, Germany., Chua RL; Center for Digital Health, Berlin Institute of Health (BIH) and Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany., Liebig J; Center for Digital Health, Berlin Institute of Health (BIH) and Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany., Thürmann L; Molecular Epidemiology Unit, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Berlin, Germany., Corman VM; Institute of Virology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Berlin, Germany., Binder M; Research group 'Dynamics of early viral infection and the innate antiviral response' (division F170), German Cancer Research Center (DKFZ), Heidelberg, Germany., Loske J; Molecular Epidemiology Unit, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Berlin, Germany., Klasa C; Institute for Bioinformatics, University Medicine Greifswald, Greifswald, Germany., Krieger T; Center for Digital Health, Berlin Institute of Health (BIH) and Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany., Hennig BP; Center for Digital Health, Berlin Institute of Health (BIH) and Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany., Messingschlager M; Molecular Epidemiology Unit, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Berlin, Germany., Pott F; Institute of Virology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Berlin, Germany.; Berlin Institute of Health (BIH), Berlin, Germany., Kazmierski J; Institute of Virology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Berlin, Germany.; Berlin Institute of Health (BIH), Berlin, Germany., Twardziok S; Center for Digital Health, Berlin Institute of Health (BIH) and Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany., Albrecht JP; Center for Digital Health, Berlin Institute of Health (BIH) and Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany., Eils J; Center for Digital Health, Berlin Institute of Health (BIH) and Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany., Hadzibegovic S; Department of Cardiology, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Berlin, Germany.; Division of Cardiology and Metabolism, Department of Cardiology Campus Virchow, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Berlin, Germany.; Centre for Cardiovascular Research (DZHK), Berlin, Germany.; Berlin Institute of Health Center for Regenerative Therapies (BCRT), Berlin, Germany., Lena A; Department of Cardiology, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Berlin, Germany.; Division of Cardiology and Metabolism, Department of Cardiology Campus Virchow, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Berlin, Germany.; Centre for Cardiovascular Research (DZHK), Berlin, Germany.; Berlin Institute of Health Center for Regenerative Therapies (BCRT), Berlin, Germany., Heidecker B; Department of Cardiology, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Berlin, Germany., Bürgel T; Center for Digital Health, Berlin Institute of Health (BIH) and Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany., Steinfeldt J; Department of Cardiology, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Berlin, Germany., Goffinet C; Institute of Virology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Berlin, Germany.; Berlin Institute of Health (BIH), Berlin, Germany., Kurth F; Department of Infectious Diseases and Respiratory Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Berlin, Germany.; Department of Tropical Medicine, Bernhard Nocht Institute for Tropical Medicine & I. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Witzenrath M; Department of Infectious Diseases and Respiratory Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Berlin, Germany., Völker MT; Department of Anesthesiology and Intensive Care, University Hospital Leipzig, Leipzig, Germany., Müller SD; Department of Anesthesiology and Intensive Care, University Hospital Leipzig, Leipzig, Germany., Liebert UG; Institute of Virology, University Hospital Leipzig, Leipzig, Germany., Ishaque N; Center for Digital Health, Berlin Institute of Health (BIH) and Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany., Kaderali L; Institute for Bioinformatics, University Medicine Greifswald, Greifswald, Germany., Sander LE; Department of Infectious Diseases and Respiratory Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Berlin, Germany., Drosten C; Institute of Virology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Berlin, Germany., Laudi S; Department of Anesthesiology and Intensive Care, University Hospital Leipzig, Leipzig, Germany. sven.laudi@medizin.uni-leipzig.de., Eils R; Center for Digital Health, Berlin Institute of Health (BIH) and Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany. roland.eils@charite.de.; German Center for Lung Research (DZL), Berlin, Germany. roland.eils@charite.de.; Health Data Science Unit, Medical Faculty and BioQuant, University of Heidelberg, Heidelberg, Germany. roland.eils@charite.de., Conrad C; Center for Digital Health, Berlin Institute of Health (BIH) and Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany. christian.conrad@charite.de., Landmesser U; Department of Cardiology, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Berlin, Germany. ulf.landmesser@charite.de., Lehmann I; Molecular Epidemiology Unit, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Berlin, Germany. irina.lehmann@charite.de.; German Center for Lung Research (DZL), Berlin, Germany. irina.lehmann@charite.de.

Publikováno v: Nature biotechnology [Nat Biotechnol] 2021 Jun; Vol. 39 (6), pp. 705-716. Date of Electronic Publication: 2020 Dec 24.