Enhanced fibril fragmentation of N-terminally truncated and Pyroglutamyl-modified Av peptides

Autor: Wulff, Melanie, Baumann, Monika, Thümmler, Anka, Yadav, Jay K., Heinrich, Liesa, Knüpfer, Uwe, Schlenzig, Dagmar, Schierhorn, Angelika, Rahfeld, Jens-Ulrich, Horn, Uwe, Balbach, Jochen, Demuth, Hans-Ulrich, Fändrich, Marcus

N-terminal truncation and pyroglutamyl (pE) formation are naturally occurring chemical modifications of the A peptide in Alzheimer's disease. We show herein that these two modifications significantly reduce the fibril length and the transition midpoi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______610::d4a3e743ffc69613c1dadc5c4025a110
https://publica.fraunhofer.de/handle/publica/244368

Enhanced Fibril Fragmentation of N-Terminally Truncated and Pyroglutamyl-Modified Aβ Peptides.

Autor: Wulff M; Institute for Pharmaceutical Biotechnologie, Ulm University, Helmholtzstrasse 8/1, 89081, Ulm, Germany., Baumann M; Institute of Physics, Martin Luther University Halle-Wittenberg, Betty-Heimann-Strasse 7, 06120, Halle (Saale), Germany., Thümmler A; Probiodrug AG, Biocenter, Weinbergweg 22, 06120, Halle (Saale), Germany.; Nomad Bioscience GmbH, Biocenter, Weinbergweg 22, 06120, Halle (Saale), Germany., Yadav JK; Department of Biotechnology, School of Life Sciences, Central University of Rajasthan, NH-8, Ajmer-, 305801, Rajasthan, India., Heinrich L; Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Beutenbergstrasse 11a, 07745, Jena, Germany., Knüpfer U; Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Beutenbergstrasse 11a, 07745, Jena, Germany., Schlenzig D; Department of Drug Design and Target Validation MWT Halle/Saale, Fraunhofer Institute for Cell Therapy and Immunology IZI Leipzig, Biocenter, Weinbergweg 22, 06120, Halle (Saale), Germany., Schierhorn A; Service Unit for Mass Spectrometry, Martin Luther University Halle-Wittenberg, Kurt-Mothes-Strasse 3, 06120, Halle (Saale), Germany., Rahfeld JU; Department of Drug Design and Target Validation MWT Halle/Saale, Fraunhofer Institute for Cell Therapy and Immunology IZI Leipzig, Biocenter, Weinbergweg 22, 06120, Halle (Saale), Germany., Horn U; Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, Beutenbergstrasse 11a, 07745, Jena, Germany., Balbach J; Institute of Physics, Martin Luther University Halle-Wittenberg, Betty-Heimann-Strasse 7, 06120, Halle (Saale), Germany., Demuth HU; Department of Drug Design and Target Validation MWT Halle/Saale, Fraunhofer Institute for Cell Therapy and Immunology IZI Leipzig, Biocenter, Weinbergweg 22, 06120, Halle (Saale), Germany., Fändrich M; Institute for Pharmaceutical Biotechnologie, Ulm University, Helmholtzstrasse 8/1, 89081, Ulm, Germany. marcus.faendrich@uni-ulm.de.

Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2016 Apr 11; Vol. 55 (16), pp. 5081-4. Date of Electronic Publication: 2016 Mar 11.