Plasma proteins elevated in severe asthma despite oral steroid use and unrelated to Type-2 inflammation

Autor: Mikus MS, Kolmert J, Andersson LI, Östling J, Knowles RG, Gómez C, Ericsson M, Thörngren JO, Khoonsari PE, Dahlén B, Kupczyk M, De Meulder B, Auffray C, Bakke PS, Beghe B, Bel EH, Caruso M, Chanez P, Chawes B, Fowler SJ, Gaga M, Geiser T, Gjomarkaj M, Horváth I, Howarth PH, Johnston SL, Joos G, Krug N, Montuschi P, Musial J, Ni?ankowska-Mogilnicka E, Olsson HK, Papi A, Rabe KF, Sandström T, Shaw DE, Siafakas NM, Uhlen M, Riley JH, Bates S, Middelveld RJM, Wheelock CE, Chung KF, Adcock IM, Sterk PJ, Djukanovic R, Nilsson P, Dahlén SE, James A, U-BIOPRED (Unbiased Biomarkers for the Prediction of Respiratory Disease outcome) Study Group, BIOAIR (Longitudinal Assessment of Clinical Course, Biomarkers in Severe Chronic Airway Disease) Consortium.

Publikováno v: The European respiratory journal 59 (2022).
info:cnr-pdr/source/autori:Mikus MS; Kolmert J; Andersson LI; Östling J; Knowles RG; Gómez C; Ericsson M; Thörngren JO; Khoonsari PE; Dahlén B; Kupczyk M; De Meulder B; Auffray C; Bakke PS; Beghe B; Bel EH; Caruso M; Chanez P; Chawes B; Fowler SJ; Gaga M; Geiser T; Gjomarkaj M; Horváth I; Howarth PH; Johnston SL; Joos G; Krug N; Montuschi P; Musial J; Ni?ankowska-Mogilnicka E; Olsson HK; Papi A; Rabe KF; Sandström T; Shaw DE; Siafakas NM; Uhlen M; Riley JH; Bates S; Middelveld RJM; Wheelock CE; Chung KF; Adcock IM; Sterk PJ; Djukanovic R; Nilsson P; Dahlén SE; James A; U-BIOPRED (Unbiased Biomarkers for the Prediction of Respiratory Disease outcome) Study Group; BIOAIR (Longitudinal Assessment of Clinical Course and Biomarkers in Severe Chronic Airway Disease) Consortium./titolo:Plasma proteins elevated in severe asthma despite oral steroid use and unrelated to Type-2 inflammation/doi:/rivista:The European respiratory journal/anno:2022/pagina_da:/pagina_a:/intervallo_pagine:/volume:59

Rationale: Asthma phenotyping requires novel biomarker discovery. Objectives: To identify plasma biomarkers associated with asthma phenotypes by application of a new proteomic panel to samples from two well-characterized cohorts of severe (SA) and mi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=cnr_________::b6811d35e98b549737ac2b607ef7c028
https://publications.cnr.it/doc/459421

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Plasma proteins elevated in severe asthma despite oral steroid use and unrelated to Type-2 inflammation.

Autor: Sparreman Mikus M; Dept of Protein Science, KTH Royal Institute of Technology, SciLifeLab, Stockholm, Sweden maria.mikus@ki.se.; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Kolmert J; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.; Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden., Andersson LI; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.; Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden., Östling J; PEXA AB, Gothenburg, Sweden., Knowles RG; Knowles Consulting, Stevenage Bioscience Catalyst, Stevenage, UK., Gómez C; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.; Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden., Ericsson M; Dept of Laboratory Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden., Thörngren JO; Dept of Laboratory Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden., Emami Khoonsari P; Dept of Biochemistry and Biophysics, National Bioinformatics Infrastructure Sweden, Science for Life Laboratory, Solna, Sweden., Dahlén B; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.; Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden.; Dept of Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden., Kupczyk M; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.; Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden.; Dept of Internal Medicine, Asthma and Allergy, Medical University of Lodz, University of Lodz, Lodz, Poland., De Meulder B; European Institute for Systems Biology and Medicine, Lyon, France., Auffray C; European Institute for Systems Biology and Medicine, Lyon, France., Bakke PS; Dept of Clinical Science, University of Bergen, Bergen, Norway., Beghe B; Dept of Medical and Surgical Sciences, University of Modena and Reggio Emilia, Modena, Italy., Bel EH; Dept of Respiratory Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands., Caruso M; Dept of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy., Chanez P; Assistance Publique des Hôpitaux de Marseille, Clinique des Bronches, Allergies et Sommeil, Aix Marseille Université, Marseille, France., Chawes B; COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark., Fowler SJ; Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, The University of Manchester; Manchester Academic Health Science Centre and NIHR Manchester Biomedical Research Centre, Manchester University Hospitals NHS Foundation Trust, Manchester, UK., Gaga M; Respiratory Medicine Dept and Asthma Centre, Athens Chest Hospital 'Sotiria', University of Athens, Athens, Greece., Geiser T; Dept for Pulmonary Medicine, University Hospital and University of Bern, Bern, Switzerland., Gjomarkaj M; Institute for Research and Biomedical Innovation, Italian National Research Council, Palermo, Italy., Horváth I; Dept of Pulmonology, Semmelweis University, Budapest, Hungary., Howarth PH; NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, and Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK., Johnston SL; National Heart and Lung Institute, Imperial College London, London, UK., Joos G; Dept of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium.; Dept of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium., Krug N; Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany., Montuschi P; Dept of Pharmacology, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy., Musial J; Dept of Internal Medicine, Jagiellonian University Medical College, Krakow, Poland., Niżankowska-Mogilnicka E; Dept of Internal Medicine, Jagiellonian University Medical College, Krakow, Poland., Olsson HK; Translational Science and Experimental Medicine, Research and Early Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Papi A; Division of lnternal and Cardiorespiratory Medicine, University of Ferrara, Ferrara, Italy., Rabe KF; Dept of Internal Medicine, Christian Albrechts University Kiel, Kiel, Germany., Sandström T; Dept of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden., Shaw DE; Respiratory Research Unit, University of Nottingham, Nottingham, UK., Siafakas NM; Dept of Thoracic Medicine, Medical School, University of Crete, Heraklion, Crete, Greece., Uhlén M; Dept of Protein Science, KTH Royal Institute of Technology, SciLifeLab, Stockholm, Sweden.; Dept of Neuroscience, Karolinska Institutet, Stockholm, Sweden., Riley JH; Respiratory Therapeutic Unit, GlaxoSmithKline, London, UK., Bates S; Respiratory Therapeutic Unit, GlaxoSmithKline, London, UK., Middelveld RJM; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.; Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden., Wheelock CE; Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden.; Dept of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.; Dept of Respiratory Medicine and Allergy, Karolinska University Hospital, Stockholm, Sweden., Chung KF; National Heart and Lung Institute, Imperial College London, London, UK., Adcock IM; National Heart and Lung Institute, Imperial College London, London, UK., Sterk PJ; Dept of Respiratory Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands., Djukanovic R; NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, and Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK., Nilsson P; Dept of Protein Science, KTH Royal Institute of Technology, SciLifeLab, Stockholm, Sweden., Dahlén SE; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.; Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden.; Dept of Respiratory Medicine and Allergy, Karolinska University Hospital, Stockholm, Sweden., James A; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.; Centre for Allergy Research, Karolinska Institutet, Stockholm, Sweden.

Publikováno v: The European respiratory journal [Eur Respir J] 2022 Feb 17; Vol. 59 (2). Date of Electronic Publication: 2022 Feb 17 (Print Publication: 2022).

Medication Adherence in Patients With Severe Asthma Prescribed Oral Corticosteroids in the U-BIOPRED Cohort.

Autor: Alahmadi FH; Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, University of Manchester, and Manchester Academic Health Science Centre and NIHR Manchester Biomedical Research Centre, Manchester University Hospitals NHS Foundation Trust, Manchester, England; Respiratory Therapy Department, College of Medical Rehabilitation Sciences, Taibah University, Medina, Saudi Arabia., Simpson AJ; Division of Sport, Health and Exercise Science, University of Hull, Hull, England., Gomez C; The Centre for Allergy Research, The Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Division of Physiological Chemistry II, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden., Ericsson M; The Doping Laboratory, The Department of Laboratory Medicine at the Karolinska University Hospital Huddinge, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Thörngren JO; The Doping Laboratory, The Department of Laboratory Medicine at the Karolinska University Hospital Huddinge, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Wheelock CE; Division of Physiological Chemistry II, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden; Department of Respiratory Medicine and Allergy, Karolinska University Hospital Solna, Stockholm, Sweden., Shaw DE; Respiratory Research Unit, University of Nottingham, Nottingham, England., Fleming LJ; National Heart and Lung Institute, Imperial College London, London, England., Roberts G; NIHR Southampton Respiratory Biomedical Research Unit, Clinical and Experimental Sciences and Human Development and Health, Southampton, England., Riley J; Respiratory Therapeutic Unit, GlaxoSmithKline, Stockley Park, London, England., Bates S; Respiratory Therapeutic Unit, GlaxoSmithKline, Stockley Park, London, England., Sousa AR; Respiratory Therapeutic Unit, GlaxoSmithKline, Stockley Park, London, England., Knowles R; Knowles Consulting, Stevenage, England., Bansal AT; Acclarogen Ltd, St John's Innovation Centre, Cambridge, England., Corfield J; Areteva R&D, Nottingham, England., Pandis I; Data Science Institute, South Kensington Campus, Imperial College London, London, England., Sun K; Data Science Institute, South Kensington Campus, Imperial College London, London, England., Bakke PS; Department of Clinical Science, University of Bergen, Bergen, Norway., Caruso M; Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy., Chanez P; Assistance Publique-Hôpitaux de Marseille, Clinique des Bronches, de l'Allergie et du Sommeil CIC Nord, Aix-Marseille Université, Marseille, France., Dahlén B; Division of Respiratory Medicine and Allergy, Department of Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden., Horvath I; Department of Pulmonology, Semmelweis University, Budapest, Hungary., Krug N; Fraunhofer Institute for Toxicology and Experimental Medicine, Hannover, Germany., Montuschi P; Università Cattolica del Sacro Cuore, Milan, Italy., Singer F; Division of Respiratory Medicine, Department of Pediatrics, Inselspital University Hospital Bern, University of Bern, Switzerland., Wagers S; BioSci Consulting, Maasmechelen, Belgium., Adcock IM; National Heart and Lung Institute, Imperial College London, London, England., Djukanovic R; NIHR Southampton Respiratory Biomedical Research Unit, Clinical and Experimental Sciences and Human Development and Health, Southampton, England., Chung KF; National Heart and Lung Institute, Imperial College London, London, England., Sterk PJ; Department of Respiratory Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands., Dahlen SE; The Centre for Allergy Research, The Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden., Fowler SJ; Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, University of Manchester, and Manchester Academic Health Science Centre and NIHR Manchester Biomedical Research Centre, Manchester University Hospitals NHS Foundation Trust, Manchester, England. Electronic address: stephen.fowler@manchester.ac.uk.

Publikováno v: Chest [Chest] 2021 Jul; Vol. 160 (1), pp. 53-64. Date of Electronic Publication: 2021 Feb 19.

Digit Ratio (2D:4D) and Physical Performance in Female Olympic Athletes.

Autor: Eklund E; Department of Women's and Children's Health, Division of Obstetrics and Gynecology, Karolinska Institutet, Stockholm, Sweden., Ekström L; Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden., Thörngren JO; Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden., Ericsson M; Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden., Berglund B; Department of Internal Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden., Hirschberg AL; Department of Women's and Children's Health, Division of Obstetrics and Gynecology, Karolinska Institutet, Stockholm, Sweden.; Department of Gynecology and Reproductive Medicine, Karolinska University Hospital, Stockholm, Sweden.

Publikováno v: Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2020 May 12; Vol. 11, pp. 292. Date of Electronic Publication: 2020 May 12 (Print Publication: 2020).