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Genotype- and sex-specific changes in vital parameters during isoflurane anesthesia in a mouse model of Alzheimer’s disease

Autor: Sebastian Bratke, Sebastian Schmid, Bernhard Ulm, Bettina Jungwirth, Manfred Blobner, Laura Borgstedt

Publikováno v: Frontiers in Medicine, Vol 11 (2024)

BackgroundThe prevalence of neurodegenerative diseases is increasing as is life expectancy with Alzheimer’s disease accounting for two-thirds of dementia cases globally. Whether general anesthesia and surgery worsen cognitive decline is still a mat

Externí odkaz: https://doaj.org/article/02853630e5444d97a2d98c82932a4506

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Evidence for a protective effect of the loss of α4-containing nicotinic acetylcholine receptors on Aβ-related neuropathology in Tg2576 mice

Autor: Antonietta Vilella, Benedetto Romoli, Martina Bodria, Stéphanie Pons, Uwe Maskos, Michele Zoli

Publikováno v: Frontiers in Neuroscience, Vol 17 (2023)

IntroductionLoss of cholinergic neurons as well as α4β2* (* = containing) nicotinic acetylcholine receptors (nAChRs) is a prominent feature of Alzheimer’s disease (AD). Specifically, amyloid β (Aβ), the principal pathogenic factor of AD, is a h

Externí odkaz: https://doaj.org/article/cfd42a1cd2a442e180af193917de7d2a

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Akademický článek

Transcriptomic Analysis in the Hippocampus and Retina of Tg2576 AD Mice Reveals Defective Mitochondrial Oxidative Phosphorylation and Recovery by Tau 12A12mAb Treatment

Autor: Giovanna Morello, Maria Guarnaccia, Valentina La Cognata, Valentina Latina, Pietro Calissano, Giuseppina Amadoro, Sebastiano Cavallaro

Publikováno v: Cells, Vol 12, Iss 18, p 2254 (2023)

Increasing evidence implicates decreased energy metabolism and mitochondrial dysfunctions among the earliest pathogenic events of Alzheimer’s disease (AD). However, the molecular mechanisms underlying bioenergetic dysfunctions in AD remain, to date

Externí odkaz: https://doaj.org/article/358f217c82594c0390666379dbfcf1f3

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The Na+/Ca2+ Exchanger 3 Is Functionally Coupled With the NaV1.6 Voltage-Gated Channel and Promotes an Endoplasmic Reticulum Ca2+ Refilling in a Transgenic Model of Alzheimer’s Disease

Autor: Ilaria Piccialli, Roselia Ciccone, Agnese Secondo, Francesca Boscia, Valentina Tedeschi, Valeria de Rosa, Pasquale Cepparulo, Lucio Annunziato, Anna Pannaccione

Publikováno v: Frontiers in Pharmacology, Vol 12 (2021)

The remodelling of neuronal ionic homeostasis by altered channels and transporters is a critical feature of the Alzheimer’s disease (AD) pathogenesis. Different reports converge on the concept that the Na+/Ca2+ exchanger (NCX), as one of the main r

Externí odkaz: https://doaj.org/article/8e0cb4508a1a497698d5ad972fae8079

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Increased KV2.1 Channel Clustering Underlies the Reduction of Delayed Rectifier K+ Currents in Hippocampal Neurons of the Tg2576 Alzheimer’s Disease Mouse

Autor: Ilaria Piccialli, Maria José Sisalli, Valeria de Rosa, Francesca Boscia, Valentina Tedeschi, Agnese Secondo, Anna Pannaccione

Publikováno v: Cells, Vol 11, Iss 18, p 2820 (2022)

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by the progressive deterioration of cognitive functions. Cortical and hippocampal hyperexcitability intervenes in the pathological derangement of brain activity leading to cogni

Externí odkaz: https://doaj.org/article/5cd534dc62ec43609fdfc48c22027f72

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Akademický článek

Long-term ovarian hormone deprivation alters functionalconnectivity, brain neurochemical profile and white matter integrityin the Tg2576 amyloid mouse model of Alzheimer's disease

Premenopausal bilateral ovariectomy is considered to be one of the risk factors of Alzheimer's disease (AD). However, the underlying mechanisms remain unclear. Here, we aimed to investigate long-term neurological consequences of ovariectomy in a rode

Externí odkaz: https://ul.qucosa.de/id/qucosa%3A94399
https://ul.qucosa.de/api/qucosa%3A94399/attachment/ATT-0/

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Akademický článek

Metabolic Profiling of Suprachiasmatic Nucleus Reveals Multifaceted Effects in an Alzheimer's Disease Mouse Model

Autor: Eezaa, Muhamed N.H., Singer, Rico, Höfling, Corinna, Matysik, Jörg, de Groot, Huub J.M., Roßner, Steffen, Aliaa, A.

Background: Circadian rhythm disturbance is commonly observed in Alzheimer's disease (AD). In mammals, these rhythms are orchestrated by the superchiasmatic nucleus (SCN). Our previous study in the Tg2576 AD mouse model suggests that inflammatory res

Externí odkaz: https://ul.qucosa.de/id/qucosa%3A93816
https://ul.qucosa.de/api/qucosa%3A93816/attachment/ATT-0/

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