Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Tg, glass transition temperature"'
Publikováno v:
International journal of pharmaceutics: X. 5
Cellulose beads emerge as carriers for poorly water-soluble drugs due to their eco-friendly raw materials and favorable porous structure. However, drug dissolution may be limited by their poor swelling ability and the presence of closed pores caused
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6579617d352b2ad2633f9809284cdcc5
https://pubmed.ncbi.nlm.nih.gov/36593986
https://pubmed.ncbi.nlm.nih.gov/36593986
Autor:
Oliver Bluemel, Moritz Anuschek, Jakob W. Buecheler, Georg Hoelzl, Karoline Bechtold-Peters, Wolfgang Friess
Publikováno v:
International Journal of Pharmaceutics: X, Vol 4, Iss, Pp 100108-(2022)
International Journal of Pharmaceutics: X
International Journal of Pharmaceutics: X
Cryoconcentration upon large-scale freezing of monoclonal antibody (mAb) solutions leads to regions of different ratios of low molecular weight excipients, like buffer species or sugars, to protein. This study focused on the impact of the buffer spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec1e879d7a95015ba4b711cb5c437c93
http://www.sciencedirect.com/science/article/pii/S2590156721000372
http://www.sciencedirect.com/science/article/pii/S2590156721000372
Autor:
Qi Tony Zhou, Yuchuan Gong, Lynne S. Taylor, Biplob Mitra, Shyam Karki, Uday Jain, Sumit Kumar, Anjali Agrawal, Sonal V Bhujbal
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 8, Pp 2505-2536 (2021)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Amorphous solid dispersions (ASDs) are popular for enhancing the solubility and bioavailability of poorly water-soluble drugs. Various approaches have been employed to produce ASDs and novel techniques are emerging. This review provides an updated ov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::067adf8960eedbc9499e5e3d7319e5f5
http://www.sciencedirect.com/science/article/pii/S2211383521001805
http://www.sciencedirect.com/science/article/pii/S2211383521001805
Publikováno v:
Current Research in Food Science
Current Research in Food Science, Vol 3, Iss, Pp 73-81 (2020)
Current Research in Food Science, Vol 3, Iss, Pp 73-81 (2020)
Maltodextrin, modified starch, inulin, alginate, gum arabic, and combinations thereof were used as carrier agents for spray drying of carotenoid-rich goldenberry (Physalis peruviana L.) juice and compared to cellobiose as an alternative carrier. Powd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::329dacb5d28d220b8267b68ce54c46b1
https://doi.org/10.1016/j.crfs.2020.03.002
https://doi.org/10.1016/j.crfs.2020.03.002
Autor:
Oliver Bluemel, Jakob W. Buecheler, Astrid Hauptmann, Georg Hoelzl, Karoline Bechtold-Peters, Wolfgang Friess
Publikováno v:
International Journal of Pharmaceutics: X
International Journal of Pharmaceutics: X, Vol 4, Iss, Pp 100109-(2022)
International Journal of Pharmaceutics: X, Vol 4, Iss, Pp 100109-(2022)
We examined the impact of monoclonal antibody (mAb) and buffer concentration, mimicking the cryoconcentration found upon freezing in a 2 L bottle, on mAb stability during frozen storage. Upon cryoconcentration, larger protein molecules and small exci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48554eb16d78e5b0127bc646e9ca6ea7
https://pubmed.ncbi.nlm.nih.gov/35024604
https://pubmed.ncbi.nlm.nih.gov/35024604
Publikováno v:
International Journal of Pharmaceutics: X, Vol 3, Iss, Pp 100102-(2021)
International Journal of Pharmaceutics: X
International Journal of Pharmaceutics: X
The present study explored vacuum drum drying (VDD) as an alternative technology for amorphous solid dispersions (ASDs) manufacture compared to hot-melt extrusion (HME) and spray drying (SD) focusing on downstream processability (powder properties, c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5652c30c962c4b6bc07f6e0b0690ee39
http://www.sciencedirect.com/science/article/pii/S2590156721000311
http://www.sciencedirect.com/science/article/pii/S2590156721000311
Autor:
Bashar Ibraheem, Karl G. Wagner
Publikováno v:
International Journal of Pharmaceutics: X, Vol 3, Iss, Pp 100075-(2021)
International Journal of Pharmaceutics: X
International Journal of Pharmaceutics: X
Enabling formulations often depend on functional excipients. However, the question remains whether excipients regarded as standard establish similar interactions and subsequently improvement of solubility when employed at unusual manufacturing proces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9c26bcf69ad09e72a26ff8a4321409b
http://www.sciencedirect.com/science/article/pii/S2590156721000049
http://www.sciencedirect.com/science/article/pii/S2590156721000049
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics
Graphical abstract
The stability of live-attenuated viruses is very challenging due to thermal sensitivity; therefore, solid form is usually required (often freeze-dried products). Micropellet technology is a lyophilization technology that has t
The stability of live-attenuated viruses is very challenging due to thermal sensitivity; therefore, solid form is usually required (often freeze-dried products). Micropellet technology is a lyophilization technology that has t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::386396326579e9e6235209f2c61551ce
https://doi.org/10.1016/j.ejpb.2019.07.008
https://doi.org/10.1016/j.ejpb.2019.07.008
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 9, Iss 1, Pp 19-35 (2019)
Acta Pharmaceutica Sinica B, Vol 9, Iss 1, Pp 19-35 (2019)
In recent years, the coamorphous drug delivery system has been established as a promising formulation approach for delivering poorly water-soluble drugs. The coamorphous solid is a single-phase system containing an active pharmaceutical ingredient (A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31cd90a5837aa2f7868b7856723ecc21
http://europepmc.org/articles/PMC6361732
http://europepmc.org/articles/PMC6361732
Autor:
Thilo Faber, Yann Pellequer, Marius Monschke, Alf Lamprecht, Karl G. Wagner, Anna K. Krome, Rafael D. Bachmaier, Edmont Stoyanov
Publikováno v:
International Journal of Pharmaceutics: X, Vol 3, Iss, Pp 100076-(2021)
International Journal of Pharmaceutics: X
International Journal of Pharmaceutics: X
Using polymers as additives to formulate ternary amorphous solid dispersions (ASDs) has successfully been established to increase the bioavailability of poorly soluble drugs, when one polymer is not able to provide both, stabilizing the drug in the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7165733c3f1d02f1297718b7b99d0e1
https://doi.org/10.1016/j.ijpx.2021.100076
https://doi.org/10.1016/j.ijpx.2021.100076