Zobrazeno 1 - 10
of 37
pro vyhledávání: '"TfR, transferrin receptor"'
Autor:
Liang Han, Chen Jiang
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 8, Pp 2306-2325 (2021)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Blood–brain barrier (BBB) strictly controls matter exchange between blood and brain, and severely limits brain penetration of systemically administered drugs, resulting in ineffective drug therapy of brain diseases. However, during the onset and pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a05eff9f72ac70fe48cb5ed9a111b5b
http://www.sciencedirect.com/science/article/pii/S2211383520308522
http://www.sciencedirect.com/science/article/pii/S2211383520308522
Publikováno v:
Bioactive Materials
Bioactive Materials, Vol 6, Iss 7, Pp 1973-1987 (2021)
Bioactive Materials, Vol 6, Iss 7, Pp 1973-1987 (2021)
The tumor development and metastasis are closely related to the structure and function of the tumor microenvironment (TME). Recently, TME modulation strategies have attracted much attention in cancer immunotherapy. Despite the preliminary success of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d9e3a12774af1e45fb188f205ad9bdc
https://doi.org/10.1016/j.bioactmat.2020.12.010
https://doi.org/10.1016/j.bioactmat.2020.12.010
Autor:
Caifang Gao, Peng Liu, Hongguo Chen, Xu Wu, Xudong Tang, Yitao Wang, Chi Teng Vong, Shengpeng Wang
Publikováno v:
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2798-2818 (2021)
Acta Pharmaceutica Sinica B, Vol 11, Iss 9, Pp 2798-2818 (2021)
Inflammatory bowel disease (IBD) is a chronic intestinal disease with painful clinical manifestations and high risks of cancerization. With no curative therapy for IBD at present, the development of effective therapeutics is highly advocated. Drug de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caf33f667c4f81b143c5ccef5cfb99fc
http://europepmc.org/articles/PMC8463263
http://europepmc.org/articles/PMC8463263
Publikováno v:
International Journal of Molecular Sciences, Vol 10, Iss 3, Pp 1226-1260 (2009)
Parkinson’s disease (PD) is the second most common progressive neurodegenerative disorder after Alzheimer's disease (AD) and represents a large health burden to society. Genetic and oxidative risk factors have been proposed as possible causes, but
Externí odkaz:
https://doaj.org/article/822a5085d4da46cd845096a9d48b92bf
Autor:
Tohru Hirato, Kohtaro Minami, Masafumi Kinoshita, Eiji Yoden, Atsushi Imakiire, Ryuji Yamamoto, Noboru Tanaka
Publikováno v:
Molecular Genetics and Metabolism Reports, Vol 27, Iss, Pp 100758-(2021)
Molecular Genetics and Metabolism Reports
Molecular Genetics and Metabolism Reports
Pabinafusp alfa is a fusion protein comprising a humanized anti-human transferrin receptor (TfR) antibody and human iduronate-2-sulfatase. It was developed as a novel modality to target central nervous system-related symptoms observed in patients wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0bad9d33274408b77250340e21baeff
http://www.sciencedirect.com/science/article/pii/S2214426921000525
http://www.sciencedirect.com/science/article/pii/S2214426921000525
Autor:
András Balla, Gábor Turu, László Hunyady, Péter Várnai, Dániel Garger, Eszter Soltész-Katona, Susanne Prokop, András Tóth
Publikováno v:
The Journal of Biological Chemistry
Reliable measurement of ligand binding to cell surface receptors is of outstanding biological and pharmacological importance. Resonance energy transfer–based assays are powerful approaches to achieve this goal, but the currently available methods a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8666eb7ce2fd2ee3fcd92d011eb7a65b
http://europepmc.org/articles/PMC7950324
http://europepmc.org/articles/PMC7950324
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 20, Iss 6, Pp 594-609 (2018)
Neoplasia (New York, N.Y.)
Neoplasia (New York, N.Y.)
Hepatocellular carcinoma (HCC) is the third most lethal cancer worldwide. Despite progress in identifying risk factors, the incidence of HCC is increasing. Moreover, therapeutic options are limited and survival is poor. Therefore, alternative and inn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71a9a0ec4a4cb12f3f5edd78c8d57e40
https://doi.org/10.1016/j.neo.2018.02.012
https://doi.org/10.1016/j.neo.2018.02.012
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 8, Iss 1, Pp 34-50 (2018)
Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Natural biomacromolecules have attracted increased attention as carriers in biomedicine in recent years because of their inherent biochemical and biophysical properties including renewability, nontoxicity, biocompatibility, biodegradability, long blo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7426b5efae73e9c0099c0a65c0e2aa0
http://www.sciencedirect.com/science/article/pii/S2211383517302812
http://www.sciencedirect.com/science/article/pii/S2211383517302812
Autor:
Salaun, Christine, Ritchie, Louise, Greaves, Jennifer, Bushell, Trevor J., Chamberlain, Luke H.
Publikováno v:
Molecular and Cellular Neurosciences
The S-acyltransferase zDHHC2 mediates dynamic S-acylation of PSD95 and AKAP79/150, which impacts synaptic targeting of AMPA receptors. zDHHC2 is responsive to synaptic activity and catalyses the increased S-acylation of PSD95 that occurs following ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::2e53e1224bd6c043f7ca53b49bce73e9
http://europepmc.org/articles/PMC5711357
http://europepmc.org/articles/PMC5711357
Autor:
Yelena Peskova, Ajit Tiwari, Arina Hadziselimovic, Ricardo Capone, James M. Hutchison, Charles R. Sanders, Anne K. Kenworthy
Publikováno v:
The Journal of Biological Chemistry
Processing of the amyloid precursor protein (APP) via the amyloidogenic pathway is associated with the etiology of Alzheimer's disease. The cleavage of APP by β-secretase to generate the transmembrane 99-residue C-terminal fragment (C99) and subsequ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ee8d557ad9fcaa7019a5d225a719185
https://doi.org/10.1016/j.jbc.2021.100652
https://doi.org/10.1016/j.jbc.2021.100652