Oral delivery of proteins and peptides: Challenges, status quo and future perspectives

Autor: Yi Lu, Zhongjian Chen, Wei Wu, Pijush Kumar Paul, Quangang Zhu, Jianping Qi

Publikováno v: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 8, Pp 2416-2448 (2021)

Proteins and peptides (PPs) have gradually become more attractive therapeutic molecules than small molecular drugs due to their high selectivity and efficacy, but fewer side effects. Owing to the poor stability and limited permeability through gastro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6732d4326595a5ad29955ebaff92173
https://doi.org/10.1016/j.apsb.2021.04.001

Nonclinical safety evaluation of pabinafusp alfa, an anti-human transferrin receptor antibody and iduronate-2-sulfatase fusion protein, for the treatment of neuronopathic mucopolysaccharidosis type II

Autor: Tohru Hirato, Kohtaro Minami, Masafumi Kinoshita, Eiji Yoden, Atsushi Imakiire, Ryuji Yamamoto, Noboru Tanaka

Publikováno v: Molecular Genetics and Metabolism Reports, Vol 27, Iss, Pp 100758-(2021)
Molecular Genetics and Metabolism Reports

Pabinafusp alfa is a fusion protein comprising a humanized anti-human transferrin receptor (TfR) antibody and human iduronate-2-sulfatase. It was developed as a novel modality to target central nervous system-related symptoms observed in patients wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0bad9d33274408b77250340e21baeff
http://www.sciencedirect.com/science/article/pii/S2214426921000525

The thermogenic characteristics of adipocytes are dependent on the regulation of iron homeostasis

Autor: Jaekwon Lee, Yongeun Kim, Jin Seon Yook, Mi Zhou, Zhenhua Liu, Young Cheul Kim, Mikyoung You, Soonkyu Chung

Publikováno v: The Journal of Biological Chemistry

The development of thermogenic adipocytes concurs with mitochondrial biogenesis, an iron-dependent pathway. Iron regulatory proteins (IRP) 1 and 2 are RNA-binding proteins that regulate intracellular iron homeostasis. IRPs bind to the iron-response e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35a7b937089c8ea5dad2ce0b62832588
https://pubmed.ncbi.nlm.nih.gov/33631196

Small interfering RNA for cancer treatment: overcoming hurdles in delivery

Autor: Alaa A. A. Aljabali, Nitin Charbe, Poonam Negi, Nikhil D. Amnerkar, Gaurav Gupta, B. Ramesh, Meenu Metha, Hamid A. Bakshi, Dinesh Kumar Chellappan, Saurabh C. Khadse, Garima Shrivastava, Saurabh Satija, Kamal Dua, Flavia C. Zacconi, Murtaza M. Tambuwala, Rajendran Satheeshkumar

Publikováno v: Acta Pharmaceutica Sinica. B

In many ways, cancer cells are different from healthy cells. A lot of tactical nano-based drug delivery systems are based on the difference between cancer and healthy cells. Currently, nanotechnology-based delivery systems are the most promising tool

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2071f422f1c1f8a688b18780d3afbc9c
https://pubmed.ncbi.nlm.nih.gov/33304780

Iron Prevents Hypoxia-Associated Inflammation Through the Regulation of Nuclear Factor-κB in the Intestinal Epithelium

Autor: Simona Simmen, Jesus Cosin-Roger, Cheryl de Valliere, Katharina Spanaus, Katharina Baebler, Chiaki Maeyashiki, Nikolaos Maliachovas, Jonas Zeitz, Gerhard Rogler, Pedro A. Ruiz, Hassan Melhem, Stephan R. Vavricka, Bruce Weder, Max Maane, Martin Hausmann, Michael Scharl

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 2, Pp 339-355 (2019)

Background & Aims: Hypoxia-associated pathways influence the development of inflammatory bowel disease. Adaptive responses to hypoxia are mediated through hypoxia-inducible factors, which are regulated by iron-dependent hydroxylases. Signals reflecti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b468eae5dd78052ab560274d719c8cf0
http://europepmc.org/articles/PMC6357696