Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Tewis, Bouwmeester"'
Autor:
Nicolas Mercado, Gabi Schutzius, Christian Kolter, David Estoppey, Sebastian Bergling, Guglielmo Roma, Caroline Gubser Keller, Florian Nigsch, Adrian Salathe, Remi Terranova, John Reece-Hoyes, John Alford, Carsten Russ, Judith Knehr, Dominic Hoepfner, Alexandra Aebi, Heinz Ruffner, Tanner C. Beck, Sajjeev Jagannathan, Calla M. Olson, Hadley E. Sheppard, Selma Z. Elsarrag, Tewis Bouwmeester, Mathias Frederiksen, Felix Lohmann, Charles Y. Lin, Susan Kirkland
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
Epidermal homeostasis requires long term stem cell function. Here, the authors apply transcriptional circuitry analysis based on integrated epigenomic profiling of primary human keratinocytes with high and low stem cell function to identify IRF2 as a
Externí odkaz:
https://doaj.org/article/0f22070deb8646359f9b585b7f128992
Autor:
David Estoppey, Gabi Schutzius, Christian Kolter, Adrian Salathe, Tiffany Wunderlin, Amandine Meyer, Florian Nigsch, Tewis Bouwmeester, Dominic Hoepfner, Susan Kirkland
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103323- (2021)
Summary: BET bromodomain inhibitors hold promise as therapeutic agents in diverse indications, but their clinical progression has been challenging and none have received regulatory approval. Early clinical trials in cancer have shown heterogeneous cl
Externí odkaz:
https://doaj.org/article/bfd4227e84094d04b3e9d533cdc982de
Autor:
David Estoppey, Chia Min Lee, Marco Janoschke, Boon Heng Lee, Kah Fei Wan, Hongping Dong, Philippe Mathys, Ireos Filipuzzi, Tim Schuhmann, Ralph Riedl, Thomas Aust, Olaf Galuba, Gregory McAllister, Carsten Russ, Martin Spiess, Tewis Bouwmeester, Ghislain M.C. Bonamy, Dominic Hoepfner
Publikováno v:
Cell Reports, Vol 19, Iss 3, Pp 451-460 (2017)
Summary: Flavivirus infections by Zika and dengue virus impose a significant global healthcare threat with no US Food and Drug Administration (FDA)-approved vaccination or specific antiviral treatment available. Here, we present the discovery of an a
Externí odkaz:
https://doaj.org/article/e28693aa57094699a61e6dab252c932b
Autor:
Diego Calabrese, Guglielmo Roma, Sebastian Bergling, Walter Carbone, Valentina Mele, Sandro Nuciforo, Isabel Fofana, Benedetta Campana, Dagmara Szkolnicka, David C Hay, Jan Tchorz, Tewis Bouwmeester, Stefan Wieland, Markus H Heim
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0221762 (2019)
Background & aimsHepatocyte-like cells (HLCs) differentiated from induced pluripotent stem cells (iPSCs) have emerged as a promising cell culture model to study metabolism, biotransformation, viral infections and inherited liver diseases. iPSCs provi
Externí odkaz:
https://doaj.org/article/eab6c893049b48f6b2729aa696405960
Autor:
Nicole L Bertschi, Annemarie Voorberg-van der Wel, Anne-Marie Zeeman, Sven Schuierer, Florian Nigsch, Walter Carbone, Judith Knehr, Devendra K Gupta, Sam O Hofman, Nicole van der Werff, Ivonne Nieuwenhuis, Els Klooster, Bart W Faber, Erika L Flannery, Sebastian A Mikolajczak, Vorada Chuenchob, Binesh Shrestha, Martin Beibel, Tewis Bouwmeester, Niwat Kangwanrangsan, Jetsumon Sattabongkot, Thierry T Diagana, Clemens HM Kocken, Guglielmo Roma
Publikováno v:
eLife, Vol 7 (2018)
Relapses of Plasmodium dormant liver hypnozoites compromise malaria eradication efforts. New radical cure drugs are urgently needed, yet the vast gap in knowledge of hypnozoite biology impedes drug discovery. We previously unraveled the transcriptome
Externí odkaz:
https://doaj.org/article/6d1126676c6b4f1ea54e1b0c7ad01e87
Autor:
Annemarie Voorberg-van der Wel, Guglielmo Roma, Devendra Kumar Gupta, Sven Schuierer, Florian Nigsch, Walter Carbone, Anne-Marie Zeeman, Boon Heng Lee, Sam O Hofman, Bart W Faber, Judith Knehr, Erica Pasini, Bernd Kinzel, Pablo Bifani, Ghislain M C Bonamy, Tewis Bouwmeester, Clemens H M Kocken, Thierry Tidiane Diagana
Publikováno v:
eLife, Vol 6 (2017)
Plasmodium liver hypnozoites, which cause disease relapse, are widely considered to be the last barrier towards malaria eradication. The biology of this quiescent form of the parasite is poorly understood which hinders drug discovery. We report a com
Externí odkaz:
https://doaj.org/article/fe01f6ed27ac49e38c3c509c4167af68
Autor:
Ewa Surdziel, Ieuan Clay, Florian Nigsch, Anke Thiemeyer, Cyril Allard, Gregory Hoffman, John S Reece-Hoyes, Tanushree Phadke, Romain Gambert, Caroline Gubser Keller, Marie-Gabrielle Ludwig, Birgit Baumgarten, Mathias Frederiksen, Dirk Schübeler, Klaus Seuwen, Tewis Bouwmeester, Barna D Fodor
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0183679 (2017)
Macrophages are key cell types of the innate immune system regulating host defense, inflammation, tissue homeostasis and cancer. Within this functional spectrum diverse and often opposing phenotypes are displayed which are dictated by environmental c
Externí odkaz:
https://doaj.org/article/ee373e8c093841f49ffecddc87bb7dda
Autor:
Enrica Saponara, Carlos Penno, Vanessa Orsini, Zhong-Yi Wang, Audrey Fischer, Alexandra Aebi, Meztli L. Matadamas-Guzman, Virginie Brun, Benoit Fischer, Margaret Brousseau, Peter O'Donnell, Jonathan Turner, Alexandra Graff Meyer, Laura Bollepalli, Giovanni d’Ario, Guglielmo Roma, Walter Carbone, Stefano Annunziato, Michael Obrecht, Nicolau Beckmann, Chandra Saravanan, Arnaud Osmont, Philipp Tropberger, Shola M. Richards, Christel Genoud, Svenja Ley, Iwona Ksiazek, Florian Nigsch, Luigi M. Terracciano, Heiko S. Schadt, Tewis Bouwmeester, Jan S. Tchorz, Heinz Ruffner
Publikováno v:
The American journal of pathology.
The roof plate-specific spondin-leucine-rich repeat-containing G-protein-coupled receptor 4/5 (Lgr4/5)-zinc and ring finger 3/ring finger protein 43 module is a master regulator of hepatic Wnt/β-catenin signaling and metabolic zonation, but its impa
Autor:
Carsten Russ, Adrian Salathe, Charles Y. Lin, John Alford, Mathias Frederiksen, Caroline Gubser Keller, Gabi Schutzius, Sajjeev Jagannathan, Sebastian Bergling, Dominic Hoepfner, Heinz Ruffner, Nicolas Mercado, Judith Knehr, Alexandra Aebi, John S. Reece-Hoyes, Guglielmo Roma, David Estoppey, Remi Terranova, Hadley E. Sheppard, Calla M. Olson, Tewis Bouwmeester, Tanner C. Beck, Susan Kirkland, Florian Nigsch, Christian Kolter, Felix Lohmann, Selma Z. Elsarrag
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
Nature Communications
Nature Communications
Resident adult epithelial stem cells maintain tissue homeostasis by balancing self-renewal and differentiation. The stem cell potential of human epidermal keratinocytes is retained in vitro but lost over time suggesting extrinsic and intrinsic regula
Autor:
Arnaud Osmont, Walter Carbone, Vanessa Orsini, Florian Nigsch, Jonathan J. Turner, Christel Genoud, Shola M Richards, Laura Bollepalli, Enrica Saponara, Svenja Ley, Zhong-Yi Wang, Giovanni d'Ario, Alexandra Aebi, Meztli L Matadamas Guzmán, Philipp Tropberger, Stefano Annunziato, Chandrassegar Saravanan, Benoit Fischer, Guglielmo Roma, Tewis Bouwmeester, Michael Obrecht, Jan S. Tchorz, Virginie Brun, Heinz Ruffner, Nicolau Beckmann, Carlos A. Penno, Margaret E. Brousseau, Peter O'Donnell, Alexandra Graff Meyer, Iwona Ksiazek, Luigi Terraciano
Background & AimsThe Rspo-Lgr4/5-Znrf3/Rnf43 module is a master regulator of hepatic Wnt/β-catenin signaling and metabolic zonation, but its impact on nonalcoholic fatty liver disease (NAFLD) remains unclear. We studied whether liver-specific loss o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a28cc1cd150989852141c4658c7ee558
https://doi.org/10.1101/2021.11.22.469602
https://doi.org/10.1101/2021.11.22.469602