Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Teun P de Boer"'
Autor:
Meye Bloothooft, Bente Verbruggen, Fitzwilliam Seibertz, Marcel A. G. van der Heyden, Niels Voigt, Teun P. de Boer
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
Background: The rapid delayed rectifier potassium current (IKr) is important for cardiac repolarization and is most often involved in drug-induced arrhythmias. However, accurately measuring this current can be challenging in human-induced pluripotent
Externí odkaz:
https://doaj.org/article/ae8be112595044e9923a346cd08dfa5f
Autor:
Chon Lok Lei, Alan Fabbri, Dominic G. Whittaker, Michael Clerx, Monique J. Windley, Adam P. Hill, Gary R. Mirams, Teun P. de Boer
Publikováno v:
Wellcome Open Research, Vol 5 (2021)
Automated patch-clamp platforms are widely used and vital tools in both academia and industry to enable high-throughput studies such as drug screening. A leak current to ground occurs whenever the seal between a pipette and cell (or internal solution
Externí odkaz:
https://doaj.org/article/a53e5521451443e3b5ff249890662cc0
Autor:
Phong D. Nguyen, Iris Gooijers, Giulia Campostrini, Arie O. Verkerk, Hessel Honkoop, Mara Bouwman, Dennis E. M. de Bakker, Tim Koopmans, Aryan Vink, Gerda E. M. Lamers, Avraham Shakked, Jonas Mars, Aat A. Mulder, Sonja Chocron, Kerstin Bartscherer, Eldad Tzahor, Christine L. Mummery, Teun P. de Boer, Milena Bellin, Jeroen Bakkers
Publikováno v:
Science, 380(6646), 758-764. American Association for the Advancement of Science
Zebrafish hearts can regenerate by replacing damaged tissue with new cardiomyocytes. Although the steps leading up to the proliferation of surviving cardiomyocytes have been extensively studied, little is known about the mechanisms that control proli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::943bee9c72057afcf68114b824ca5b6c
https://doi.org/10.1126/science.abo6718
https://doi.org/10.1126/science.abo6718
Autor:
Sebastiaan J. van Kampen, Su Ji Han, Willem B. van Ham, Eirini Kyriakopoulou, Elizabeth W. Stouthart, Birgit Goversen, Jantine Monshouwer-Kloots, Ilaria Perini, Hesther de Ruiter, Petra van der Kraak, Aryan Vink, Linda W. van Laake, Judith A. Groeneweg, Teun P. de Boer, Hoyee Tsui, Cornelis J. Boogerd, Toon A.B. van Veen, Eva van Rooij
Publikováno v:
Stem Cell Reports. 18:749-764
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee9731983c42617636e28f39b28b5143
https://doi.org/10.1016/j.stemcr.2023.01.015
https://doi.org/10.1016/j.stemcr.2023.01.015
Autor:
Christiaan C. Veerman, Isabella Mengarelli, Charlotte D. Koopman, Ronald Wilders, Shirley C. van Amersfoorth, Diane Bakker, Rianne Wolswinkel, Mariam Hababa, Teun P. de Boer, Kaomei Guan, James Milnes, Elisabeth M. Lodder, Jeroen Bakkers, Arie O. Verkerk, Connie R. Bezzina
Publikováno v:
Disease Models & Mechanisms, Vol 12, Iss 7 (2019)
Mutations in GNB5, encoding the G-protein β5 subunit (Gβ5), have recently been linked to a multisystem disorder that includes severe bradycardia. Here, we investigated the mechanism underlying bradycardia caused by the recessive p.S81L Gβ5 variant
Externí odkaz:
https://doaj.org/article/9a0498e951bf479a8ce5b96fc11940df
Autor:
Birgit Goversen, Nadine Becker, Sonja Stoelzle-Feix, Alison Obergrussberger, Marc A. Vos, Toon A. B. van Veen, Niels Fertig, Teun P. de Boer
Publikováno v:
Frontiers in Physiology, Vol 8 (2018)
An important aspect of the Comprehensive In Vitro Proarrhythmia Assay (CiPA) proposal is the use of human stem cell-derived cardiomyocytes and the confirmation of their predictive power in drug safety assays. The benefits of this cell source are clea
Externí odkaz:
https://doaj.org/article/1bd90539b3c140a9a5fc0ad85b3a1c86
Autor:
Alexander P. Clark, Michael Clerx, Siyu Wei, Chon Lok Lei, Teun P. de Boer, Gary R. Mirams, David J. Christini, Trine Krogh-Madsen
Human induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) have become an essential tool to study arrhythmia mechanisms. Much of the foundational work on these cells, and the computational models built from the resultant data, has overlook
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::00ed2bc62fb226b8bcd15bdcb5691ce2
https://doi.org/10.1101/2022.10.13.511949
https://doi.org/10.1101/2022.10.13.511949
Autor:
Jeroen Bakkers, Teun P. de Boer, Mohankrishna Dalvoy Vasudevarao, Alberto Bertozzi, Medhanie A. Mulaw, Charlotte D. Koopman, Chi-Chung Wu, Phong D. Nguyen, Gilbert Weidinger
Publikováno v:
Developmental Biology. Academic Press
Adult zebrafish are frequently described to be able to "completely" regenerate the heart. Yet, the extent to which cardiomyocytes lost to injury are replaced is unknown, since existing evidence for cardiomyocyte proliferation is indirect or non-quant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::820ccc25d4e5bda7cb5136c9d953c375
https://doi.org/10.1016/j.ydbio.2020.12.004
https://doi.org/10.1016/j.ydbio.2020.12.004
Autor:
Teun P. de Boer, Malin K.B. Jonsson, Toon A.B. van Veen, Nikki H.L. van den Heuvel, Marc A. Vos, Birgit Goversen, Rianne Rijken
Publikováno v:
Progress in Biophysics and Molecular Biology. 149:86-98
The human Ether-a-go-go Related Gene (hERG) encodes the pore forming subunit of the channel that conducts the rapid delayed rectifier potassium current IKr. IKr drives repolarization in the heart and when IKr is dysfunctional, cardiac repolarization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3d23152e25729459e698b6d6e3a45c3
https://doi.org/10.1016/j.pbiomolbio.2019.02.003
https://doi.org/10.1016/j.pbiomolbio.2019.02.003
Autor:
Anne Zwartsen, Carol Ann Remme, Igor R. Efimov, Teun P. de Boer, Antje Banning, Marc A. Vos, Alex V. Postma, Joanne J.A. van Bavel, Leonie van Stuijvenberg, Toon A.B. van Veen, Mathilde R. Rivaud, Aryan Vink, Elise L. Kessler, Ritva Tikkanen, Joelle van Bennekom, J. Peter van Tintelen
Publikováno v:
Journal of Molecular and Cellular Cardiology, 126, 86. Academic Press Inc.
Journal of molecular and cellular cardiology, 126, 86-95. Academic Press Inc.
Journal of molecular and cellular cardiology, 126, 86-95. Academic Press Inc.
Background The intercalated disc (ID) is important for cardiac remodeling and has become a subject of intensive research efforts. However, as yet the composition of the ID has still not been conclusively resolved and the role of many proteins identif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c17dba8e48eb60e54d1c2d85223c2540
https://doi.org/10.1016/j.yjmcc.2018.11.007
https://doi.org/10.1016/j.yjmcc.2018.11.007