Sound-evoked adenosine release in cooperation with neuromodulatory circuits permits auditory cortical plasticity and perceptual learning.

Autor: Bayazitov IT; Division of Neural Circuits and Behavior, Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Teubner BJW; Division of Neural Circuits and Behavior, Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Feng F; Division of Neural Circuits and Behavior, Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Wu Z; School of Life Sciences, Peking University, Beijing 100871, China., Li Y; School of Life Sciences, Peking University, Beijing 100871, China., Blundon JA; Division of Neural Circuits and Behavior, Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Zakharenko SS; Division of Neural Circuits and Behavior, Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address: stanislav.zakharenko@stjude.org.

Publikováno v: Cell reports [Cell Rep] 2024 Feb 27; Vol. 43 (2), pp. 113758. Date of Electronic Publication: 2024 Feb 13.

Alzheimer's disease-associated U1 snRNP splicing dysfunction causes neuronal hyperexcitability and cognitive impairment.

Autor: Chen PC; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Han X; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Integrated Biomedical Sciences Program, University of Tennessee Health Science Center, Memphis, TN 38163, USA., Shaw TI; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Biostatistics and Bioinformatics, Moffitt Cancer Center, Tampa, FL 33612, USA., Fu Y; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Sun H; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Niu M; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Wang Z; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Jiao Y; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Teubner BJW; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Eddins D; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Beloate LN; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Present address: Department of Biomedical Engineering and Electrical Engineering, Penn State University, State College, PA 16801, USA., Bai B; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Present address: Department of Laboratory Medicine, Center for Precision Medicine, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, Jiangsu 210008, China., Mertz J; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Present address: GlaxoSmithKline, Rockville, MD 20850, USA., Li Y; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Cho JH; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Wang X; Integrated Biomedical Sciences Program, University of Tennessee Health Science Center, Memphis, TN 38163, USA.; Present address: Department of Biology, University of North Dakota, Grand Forks, ND 58202, USA., Wu Z; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Liu D; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Poudel S; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Yuan ZF; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Mancieri A; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Low J; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Lee HM; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Patton MH; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Earls LR; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Present address: Department of Biological Sciences, Loyola University of New Orleans, LA 70118, USA., Stewart E; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Vogel P; Veterinary Pathology Core, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Hui Y; Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Wan S; Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Bennett DA; Department of Neurological Sciences, Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL 60612, USA., Serrano GE; Banner Sun Health Research Institute, Sun City, AZ 85351, USA., Beach TG; Banner Sun Health Research Institute, Sun City, AZ 85351, USA., Dyer MA; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Smeyne RJ; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Present address: Department of Neuroscience, Thomas Jefferson University, Philadelphia, PA 19107, USA., Moldoveanu T; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Present address: Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AK 72205, USA., Chen T; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Wu G; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Zakharenko SS; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Yu G; Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.; Present address: Department of Neuroscience, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Peng J; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.; Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

Publikováno v: Nature aging [Nat Aging] 2022 Oct; Vol. 2 (10), pp. 923-940. Date of Electronic Publication: 2022 Oct 12.

Noncanonical function of an autophagy protein prevents spontaneous Alzheimer's disease.

Autor: Heckmann BL; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA., Teubner BJW; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA., Boada-Romero E; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA., Tummers B; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA., Guy C; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA., Fitzgerald P; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA., Mayer U; School of Biological Sciences, University of East Anglia, Norwich, Norfolk, UK., Carding S; Quadram Institute of Bioscience, Norwich, Norfolk, UK., Zakharenko SS; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, USA., Wileman T; Quadram Institute of Bioscience, Norwich, Norfolk, UK.; Norwich Medical School, University of East Anglia, Norwich, Norfolk, UK., Green DR; Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.

Publikováno v: Science advances [Sci Adv] 2020 Aug 14; Vol. 6 (33), pp. eabb9036. Date of Electronic Publication: 2020 Aug 14 (Print Publication: 2020).

The COPII cargo adapter SEC24C is essential for neuronal homeostasis.

Autor: Wang B; Department of Pathology.; Department of Cell and Molecular Biology., Joo JH; Department of Pathology.; Department of Cell and Molecular Biology., Mount R; Department of Pathology.; Department of Cell and Molecular Biology., Teubner BJW; Department of Developmental Neurobiology, and., Krenzer A; Department of Pathology.; Department of Cell and Molecular Biology., Ward AL; Department of Pathology.; Department of Cell and Molecular Biology., Ichhaporia VP; Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Adams EJ; Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, Michigan, USA., Khoriaty R; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA., Peters ST; Department of Cell and Molecular Biology.; Center for Advanced Genome Engineering, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Pruett-Miller SM; Department of Cell and Molecular Biology.; Center for Advanced Genome Engineering, St. Jude Children's Research Hospital, Memphis, Tennessee, USA., Zakharenko SS; Department of Developmental Neurobiology, and., Ginsburg D; Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, Michigan, USA.; Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA.; Howard Hughes Medical Institute, Life Sciences Institute, and Departments of Human Genetics and Pediatrics, University of Michigan, Ann Arbor, Michigan, USA., Kundu M; Department of Pathology.; Department of Cell and Molecular Biology.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2018 Aug 01; Vol. 128 (8), pp. 3319-3332. Date of Electronic Publication: 2018 Jun 25.

CRTC1 Nuclear Translocation Following Learning Modulates Memory Strength via Exchange of Chromatin Remodeling Complexes on the Fgf1 Gene.

Autor: Uchida S; Division of Neuropsychiatry, Department of Neuroscience, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505, Japan; Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan; Department of Genetics, Rutgers University, 145 Bevier Road, Piscataway, NJ 08854, USA. Electronic address: s-uchida@yamaguchi-u.ac.jp., Teubner BJW; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA., Hevi C; Department of Genetics, Rutgers University, 145 Bevier Road, Piscataway, NJ 08854, USA., Hara K; Division of Neuropsychiatry, Department of Neuroscience, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505, Japan., Kobayashi A; Division of Neuropsychiatry, Department of Neuroscience, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505, Japan., Dave RM; Department of Genetics, Rutgers University, 145 Bevier Road, Piscataway, NJ 08854, USA., Shintaku T; Division of Neuropsychiatry, Department of Neuroscience, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505, Japan., Jaikhan P; Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 1-5 Shimogamohangi-Cho, Sakyo-Ku, Kyoto 606-0823, Japan., Yamagata H; Division of Neuropsychiatry, Department of Neuroscience, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505, Japan; Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan., Suzuki T; Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Agency (JST), 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan; Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 1-5 Shimogamohangi-Cho, Sakyo-Ku, Kyoto 606-0823, Japan., Watanabe Y; Division of Neuropsychiatry, Department of Neuroscience, Yamaguchi University Graduate School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505, Japan., Zakharenko SS; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA., Shumyatsky GP; Department of Genetics, Rutgers University, 145 Bevier Road, Piscataway, NJ 08854, USA. Electronic address: gleb@biology.rutgers.edu.

Publikováno v: Cell reports [Cell Rep] 2017 Jan 10; Vol. 18 (2), pp. 352-366.