Analysis of the airway microbiota of healthy individuals and patients with chronic obstructive pulmonary disease by T-RFLP and clone sequencing.

Autor: Tetyana Zakharkina, Elke Heinzel, Rembert A Koczulla, Timm Greulich, Katharina Rentz, Josch K Pauling, Jan Baumbach, Mathias Herrmann, Christiane Grünewald, Hendrik Dienemann, Lutz von Müller, Robert Bals

Publikováno v: PLoS ONE, Vol 8, Iss 7, p e68302 (2013)

UnlabelledChronic obstructive pulmonary disease (COPD) is a progressive, inflammatory lung disease that affects a large number of patients and has significant impact. One hallmark of the disease is the presence of bacteria in the lower airways.Object

Externí odkaz: https://doaj.org/article/be73a2c92cd14b3c929961da61ff8cf0

Untargeted Molecular Analysis of Exhaled Breath as a Diagnostic Test for Ventilator-Associated Lower Respiratory Tract Infections (BreathDx)

Autor: Pouline Mp, van Oort, Tamara M, Nijsen, Iain R, White, Hugo H, Knobel, Timothy, Felton, Nicholas, Rattray, Oluwasola, Lawal, Murtaza, Bulut, Waqar, Ahmed, Antonio, Artigas, Pedro R, Povoa, Ignacio, Martin-Loeches, Hans, Weda, Royston, Goodacre, Marcus J, Schultz, Paul M, Dark, Stephen J, Fowler, Lieuwe D, Bos, Tetyana, Zakharkina

Publikováno v: BreathDx Consortium, van Oort, P M, Nijsen, T M, White, I R, Knobel, H H, Felton, T, Rattray, N, Lawal, O, Bulut, M, Ahmed, W, Artigas, A, Povoa, P R, Martin-Loeches, I, Weda, H, Goodacre, R, Schultz, M J, Dark, P M, Fowler, S J & Bos, L D 2022, ' Untargeted Molecular Analysis of Exhaled Breath as a Diagnostic Test for Ventilator-Associated Lower Respiratory Tract Infections (BreathDx) ', Thorax, vol. 77, no. 1, pp. 79-81 . https://doi.org/10.1136/thoraxjnl-2021-217362
Thorax, 77(1):217362, 79-81. BMJ Publishing Group
van Oort, P M, Nijsen, T M, White, I R, Knobel, H H, Felton, T, Rattray, N, Lawal, O, Bulut, M, Ahmed, W, Artigas, A, Povoa, P R, Martin-Loeches, I, Weda, H, Goodacre, R, Schultz, M J, Dark, P M, Fowler, S J & Bos, L D 2022, ' Untargeted Molecular Analysis of Exhaled Breath as a Diagnostic Test for Ventilator-Associated Lower Respiratory Tract Infections (BreathDx) ', Thorax, vol. 77, no. 1, pp. 79-81 . https://doi.org/10.1136/thoraxjnl-2021-217362
Thorax, 77(1), 79-81. BMJ Publishing Group
Thorax

Patients suspected of ventilator-associated lower respiratory tract infections (VA-LRTIs) commonly receive broad-spectrum antimicrobial therapy unnecessarily. We tested whether exhaled breath analysis can discriminate between patients suspected of VA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78097ec60e1a378d79dffa8da9aea614
https://doi.org/10.1136/thoraxjnl-2021-217362

The dynamics of the pulmonary microbiome during mechanical ventilation in the intensive care unit and the association with occurrence of pneumonia

Autor: Menno de Jong, Sébastien Matamoros, B. de Wever, Jorrit J. Hofstra, Pedro Póvoa, Antoni Torres, Marcus J. Schultz, Antonio Artigas, Peter J. Sterk, Lieuwe D. J. Bos, Ignacio Martin-Loeches, Janine B. Kastelijn, Tetyana Zakharkina

Publikováno v: Thorax, 72(9), 803-810. BMJ Publishing Group
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Agência para a Sociedade do Conhecimento (UMIC)-FCT-Sociedade da Informação
instacron:RCAAP

RATIONALE: Ventilator-associated pneumonia (VAP) is the most common nosocomial infections in patients admitted to the ICU. The adapted island model predicts several changes in the respiratory microbiome during intubation and mechanical ventilation. O

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63720dfd58833d5591ffca43c1a847b0
https://pure.amc.nl/en/publications/the-dynamics-of-the-pulmonary-microbiome-during-mechanical-ventilation-in-the-intensive-care-unit-and-the-association-with-occurrence-of-pneumonia(72f56c75-b81a-43b1-a5ba-b83882dbebc2).html

Levels of cytokines in broncho-alveolar lavage fluid, but not in plasma, are associated with levels of markers of lipid peroxidation in breath of ventilated ICU patients

Autor: Margit, Boshuizen, Jan Hendrik, Leopold, Tetyana, Zakharkina, Hugo H, Knobel, Hans, Weda, Tamara M E, Nijsen, Teunis J, Vink, Peter J, Sterk, Marcus J, Schultz, Lieuwe D J, Bos, Tom, van der Poll

Publikováno v: Journal of breath research, 9(3). IOP Publishing Ltd.

Alkanes and alkenes in the breath are produced through fatty acid peroxidation, which is initialized by reactive oxygen species. Inflammation is an important cause and effect of reactive oxygen species. We aimed to evaluate the association between fa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17797355c8d0fa707c18721402082379
https://pubmed.ncbi.nlm.nih.gov/26333527

Detection of microorganisms in exhaled breath condensate during acute exacerbations of COPD

Autor: Tetyana, Zakharkina, A-Rembert, Koczulla, Olga, Mardanova, Akira, Hattesohl, Robert, Bals

Publikováno v: Respirology (Carlton, Vic.). 16(6)

One hallmark of COPD is colonization and infection of the lung. Acute exacerbations of COPD (AECOPD) are acute deteriorations of the chronic disease and are associated with a change of the pulmonary microbial balance. The collection of exhaled breath

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5b88d957d95dda1f4a82a4fbcd73c5c6
https://pubmed.ncbi.nlm.nih.gov/21470340