Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Tetsuyuki Nasu"'
Publikováno v:
British Journal of Pharmacology. 148:200-207
Protease-activated receptor (PAR)-2 plays important roles in intestinal inflammatory responses. Changes in PAR-2-mediated smooth muscle function may contribute pathophysiologically to the intestinal motility disorders often observed in inflammatory b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::983acdcce1b7af0bfdb1e3ff20933263
https://doi.org/10.1038/sj.bjp.0706717
https://doi.org/10.1038/sj.bjp.0706717
Autor:
Tetsuyuki Nasu
Publikováno v:
Fundamental & Clinical Pharmacology. 14:569-575
The present study was undertaken to clarify the effects of zinc ions (Zn2+) on Ca2+ uptake during histamine-induced contraction in guinea-pig taenia coli. Zn2+ (0.3 mM) had smaller effect on the initial phasic response to 10(-5) M histamine accompani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed85ec32a669ae3d2890c8cf93e73c27
https://doi.org/10.1111/j.1472-8206.2000.tb00442.x
https://doi.org/10.1111/j.1472-8206.2000.tb00442.x
Autor:
Tetsuyuki Nasu, Shuichi Ou
Publikováno v:
Fundamental & Clinical Pharmacology. 14:187-192
The neuroleptic phenothiazine derivative chlorpromazine (CPZ) at high concentration (1 x 10(-5) M) decreased either the phasic or tonic contraction in response to carbachol and the carbachol-induced increase in [Ca2+]i in both phases in ileal muscle.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66faeb1c5afaba1850cb0018ee0844ec
https://doi.org/10.1111/j.1472-8206.2000.tb00015.x
https://doi.org/10.1111/j.1472-8206.2000.tb00015.x
Publikováno v:
Fundamental & Clinical Pharmacology. 13:547-554
Fusobacterium necrophorum haemolysin (0.5-3.1 mg protein/mL) dose-dependently induced contractions of the isolated ileal longitudinal smooth muscle of the guinea-pig. The haemolysin (3.1 mg protein/mL) -induced maximum contraction of 75% of the respo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::028c56834886d3e33658808a0b0e39f8
https://doi.org/10.1111/j.1472-8206.1999.tb00360.x
https://doi.org/10.1111/j.1472-8206.1999.tb00360.x
Autor:
Nozomi Suzuki, Tetsuyuki Nasu
Publikováno v:
Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology. 120:137-143
The mechanism of the inhibition of K(+)-induced contraction caused by aluminum ions (Al3+) was analyzed in ileal longitudinal muscle and taenia coli of guinea-pig. Al3+ (2-5 mM) inhibited dose-dependently the high-K+ (60 mM, hypertonic)-induced contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::498062c6ca59e28b43603843cb17ad34
https://doi.org/10.1016/s0742-8413(98)00034-6
https://doi.org/10.1016/s0742-8413(98)00034-6
Autor:
Miyori Sasaki, Tetsuyuki Nasu
Publikováno v:
Journal of Pharmacy and Pharmacology. 50:311-315
We have studied the effects of Mn2+ on the contractile response induced by Bay K 8644, a dihydropyridine Ca2+ agonist, on guinea-pig taenia coli. Mn2+ (5 mm) completely inhibited Bay K 8644 (10−6 m)-induced rhythmic contraction and contracture to b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::297ff0cf063603f29a3c288d4a899cbc
https://doi.org/10.1111/j.2042-7158.1998.tb06866.x
https://doi.org/10.1111/j.2042-7158.1998.tb06866.x
Autor:
Tetsuyuki Nasu, Akiko Shibata
Publikováno v:
European Journal of Pharmacology. 333:199-205
In Ca2+- and Na+-deficient, isotonic 126 mM K+ medium, addition of 5 mM Mn2+ caused a tension about 2.5× greater than the tonic response induced by 126 mM K+ medium (Ca2+ 2.5 mM, Na+ 0 mM) in ileal muscle. When glycogen was depleted by incubation in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79ce59062c356ecde28b922f13614b9a
https://doi.org/10.1016/s0014-2999(97)01120-5
https://doi.org/10.1016/s0014-2999(97)01120-5
Autor:
K. Baba, Tetsuyuki Nasu
Publikováno v:
General Pharmacology: The Vascular System. 28:503-507
1. 1. Mn2+ (5 mM) evoked the contraction of ileal longitudinal muscle in a Ca2+-free, high-K+(60 mM) medium. Metabolic inhibitors, such as iodoacetic acid or glucose removal, reduced the contraction by Mn2+ in the Ca2+-free, high-K+ medium, suggestin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d05ba91fc11445c7f6334a0999164a80
https://doi.org/10.1016/s0306-3623(96)00279-0
https://doi.org/10.1016/s0306-3623(96)00279-0
Publikováno v:
General Pharmacology: The Vascular System. 28:421-425
1. 1. The mechanism of tension inhibitory effects on histamine and caffeine-induced responses by hydralazine were studied in the ileal longitudinal muscle and taenia coli of the guinea-pig. Hydralazine, 10 −4 to 3 × 10 −3 M, inhibited both the t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58e8ed8c052c78bde98da73a3216654d
https://doi.org/10.1016/s0306-3623(96)00244-3
https://doi.org/10.1016/s0306-3623(96)00244-3
Publikováno v:
General Pharmacology: The Vascular System. 27:513-517
1. Dantrolene (10(-5)-10(-4) M) reduced the K+ (60 mM) tonic response in accordance with decreased Ca2+ uptake, as determined by La method, more than the phasic in ileal muscle. 2. After saponin-treatment of the fibers, which leaves the Ca2+ storage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c758cb40c51ce4f81b30ee637b651f1
https://doi.org/10.1016/0306-3623(95)00102-6
https://doi.org/10.1016/0306-3623(95)00102-6