Výsledky vyhledávání - "Tetsuyoshi Yokoshima"

Metabolic Studies on CS-670, A New 2-Arylpropionic Acid Nonsteroidal Anti-inflammatory Drug. (1). Absorption, Metabolism and Excretion of 14C-CS-670 in Mice, Rats and Dogs

Autor: Yorihisa Tanaka, Eiichi Nakajima, Toshiharu Ohtsuki, Takayoshi Mitsui, Matsuo Takaichi, Mayumi Yamamura, Masato Asami, Wataru Takasaki, Tetsuyoshi Yokoshima

Publikováno v: Drug Metabolism and Pharmacokinetics. 10:637-650

The absorption, metabolism and excretion of CS-670 were studied in mice, rats and dogs after oral administration of 14C-labeled compound.1. After oral dosing to mice at a dose of 10 mg/kg, total radioactivity in plasma reached the Cm., of 15.8μg/ml

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9e9633cfdf29c2169471e34de5b601a9
https://doi.org/10.2133/dmpk.10.637

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Studies on the Metabolic Fate of 3H-TJN-101. (VI). Blood and Plasma Concentration Profiles and Excretion after Intravenous Administration to Rats and Dogs

Autor: Yoshitaka Jin, Yoshio Esumi, Katsuyuki Hori, Tetsuyoshi Yokoshima, Tsutomu Oyama, Shuichi Takeda, Yutaka Matsuzaki, Masaki Aburada

Publikováno v: Drug Metabolism and Pharmacokinetics. 7:569-576

The distribution (blood or plasma concentration) and excretion of 3H-TJN-101 were examined in male rats and dogs after intravenous administration (4 mg/kg). 1. In male rats, the blood level of radioactivity ranged from 1.00 to 1.13μg/ml (TJN-101 bas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::01d6453eb53e935be800b9e30ee162c1
https://doi.org/10.2133/dmpk.7.569

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Pharmacokinetic Studies of 6-Amidino-2-naphthyl 4-((4,5-dihydro-1H-imidazol-2-yl)amino)benzoate dimethanesulfonate (FUT-187). (3). Whole-body Autoradiography after a Single Oral Administration to Rats

Autor: Masaoki Shibuya, Yoshio Esumi, Tetsuyoshi Yokoshima, Matsuo Takaichi, Shinzo Komatsu, Yoshiharu Katami, Yasuro Kawaguch, Yuuko Ohbe

Publikováno v: Drug Metabolism and Pharmacokinetics. 7:177-201

6-Amidino-2-naphthyl 4-[(4, 5-dihydro-1H-imidazol-2-yl)amino]benzoate dimethanesulfonate (FUT-187), a novel protease inhibitor, is a ester of 4-[(4, 5-dihydro-1H-imidazol-2-yl)amino]benzoic acid (IABA) and 6-amidino-2-naphthol (AN). During the course

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::78a331ff31ccdf0c8a4120946fead1e7
https://doi.org/10.2133/dmpk.7.177

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Studies on the Metabolic Fate of Felodipine. (V): Absorption, Distribution, Metabolism and Excretion after a Single Oral Administration to Dogs

Autor: Hiroshi Sano, Hideaki Tohjo, Hiroshi Sato, Yoshiharu Katami, Eijiro Tagashira, Sachiko Yatsu, Yoshio Esumi, Tetsuyoshi Yokoshima, Seiji Toyama

Publikováno v: Drug Metabolism and Pharmacokinetics. 7:461-476

The absorption, distribution, metabolism and excretion of 14C-nizatidine were studied after a single oral or intravenous administration of 5 mg/kg to rats.1. The blood levels of radioactivity reached a maximum concentration at 30 min after oral admin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2fc1a563e87bbfdd9e593a1c179e85c3
https://doi.org/10.2133/dmpk.7.461

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Studies on the Metabolic Fate of 3H-TJN-101. (IV): Metabolism of TJN-101 in Rats

Autor: Eikichi Hosoya, Masaki Aburada, Yukinobu Ikeya, Hiroshi Mitsuhashi, Yoshio Esumi, Yoshitaka Jin, Yutaka Matsuzaki, Shuichi Takeda, Tsutomu Oyama, Hiromi Sasaki, Tetsuyoshi Yokoshima, Tamae Matsuzaki, Hisako Ishikawa

Publikováno v: Drug Metabolism and Pharmacokinetics. 7:519-527

The Metabolism of TJN-101 was studied in rats after oral administration of 3H-TJN-101. 1. At 0.75hr after the oral administration of 3H-TJN-101 (4mg/kg) to fasted rats, 30.0%, 18.1%, and 8.5% of the radioactivity was present in the plasma as unchange

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::27479e842442751e7236402cb1233e71
https://doi.org/10.2133/dmpk.7.519

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Studies on the Metabolic Fate of 3H-TJN-101. (V). Absorption, Metabolism and Excretion after Single Oral Administration to Dogs

Autor: Shuichi Takeda, Tetsuyoshi Yokoshima, Yoshio Esumi, Masaki Aburada, Tsutomu Oyama, Yoshitaka Jin, Katsuyuki Hori, Yutaka Matsuzaki

Publikováno v: Drug Metabolism and Pharmacokinetics. 7:557-567

We have investigate the absorption, excretion and metabolism of 3H-TJN-101 following single oral administration of the drug (4 mg/kg) in male dogs. 1. The concentration of radioactivity in the blood was determined by the dry method. The Cmax of 1666n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0683ddd4629b1ae941c4d53d151d7633
https://doi.org/10.2133/dmpk.7.557

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Pharmacokinetic studies of mofezolac. I: Absorption, distribution and excretion after oral administration of 14C-mofezolac to rats

Autor: Naomi Yatabe, Yasuro Kawaguchi, Hirotoshi Masuda, Koichi Mitsugi, Takashi Shindo, Isao Watanabe, Tetsuyoshi Yokoshima, Takashi Suzuki, Yoshio Esumi, Takashi Kawauchi

Publikováno v: Drug Metabolism and Pharmacokinetics. 5:383-403

The absorption, distribution and excretion of [3, 4-di(4-methoxyphenyl)-5-isoxazolyl] acetic acid (mofezolac) were studied in rats after a single or repeated oral administration of 14C-labeled-mofezolac.1. Concentration of radioactivity in the blood

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e4484941ebeaa04ca321e666fab3ddaf
https://doi.org/10.2133/dmpk.5.383

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The effect of 4-substituent of benzoic acid on glycine conjugation

Autor: Michio Yamaguchi, Takao Ueda, Tetsuyoshi Yokoshima, Noboru Fukasaku, Toshio Nanbo, Hideyuki Takagi

Publikováno v: Chemical and Pharmaceutical Bulletin. 38:1753-1754

The relationship between the glycine conjugation of 4-substituted derivatives of benzoic acid and physico-chemical property was studied using rats. A linear relationship was found between the lipophilicity and the glycine conjugation after the intrav

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e062ae67689b095557c201898f9f90d6
https://doi.org/10.1248/cpb.38.1753

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