Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Tetsuya Okada"'
Publikováno v:
Cell Structure and Function, Vol 48, Iss 2, Pp 123-133 (2023)
When medaka fish (Oryzias latipes) larvae are grown in the absence of exogenous nutrition, the liver becomes dark and positive to Oil Red O staining from 7 days post-hatch (dph). We determined the mechanism of this starvation-induced development of f
Externí odkaz:
https://doaj.org/article/a78d8829b38844bb84463121c3fd2031
Publikováno v:
eLife, Vol 11 (2022)
A causal relationship between endoplasmic reticulum (ER) stress and the development of neurodegenerative diseases remains controversial. Here, we focused on Seipinopathy, a dominant motor neuron disease, based on the finding that its causal gene prod
Externí odkaz:
https://doaj.org/article/73a05867761f4df3b32bbec93c3782ca
Autor:
Akira Imamura, Tetsuya Okada, Hikaru Mase, Takuya Otani, Tomoka Kobayashi, Manatsu Tamura, Bruno Kilunga Kubata, Katsuaki Inoue, Robert P. Rambo, Susumu Uchiyama, Kentaro Ishii, Shigenori Nishimura, Takashi Inui
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Trypanosoma brucei guanosine 5′-monophosphate reductase (TbGMPR) catalyses the conversion of GMP to inosine 5′-monophosphate and contains a cystathionine-β-synthase (CBS) domain. Here the authors combine X-ray crystallography and kinetic measure
Externí odkaz:
https://doaj.org/article/285564165cb4499dbcb3b1543a57c253
Autor:
Ginto George, Satoshi Ninagawa, Hirokazu Yagi, Jun-ichi Furukawa, Noritaka Hashii, Akiko Ishii-Watabe, Ying Deng, Kazutoshi Matsushita, Tokiro Ishikawa, Yugoviandi P Mamahit, Yuta Maki, Yasuhiro Kajihara, Koichi Kato, Tetsuya Okada, Kazutoshi Mori
Publikováno v:
eLife, Vol 10 (2021)
Sequential mannose trimming of N-glycan, from M9 to M8B and then to oligosaccharides exposing the α1,6-linked mannosyl residue (M7A, M6, and M5), facilitates endoplasmic reticulum-associated degradation of misfolded glycoproteins (gpERAD). We previo
Externí odkaz:
https://doaj.org/article/341ffd41c9234c5d998d7ae1195a462d
Publikováno v:
Materials, Vol 15, Iss 13, p 4513 (2022)
Drop–dry deposition (DDD) is a method of depositing thin films by heating and drying the deposition solution dropped on a substrate. We prepared Ni(OH)2 precursor thin films by DDD and annealed them in air to prepare NiO thin films. The appropriate
Externí odkaz:
https://doaj.org/article/91e817f8d0104649b5d6d8cae41e0fa3
Autor:
Ginto George, Satoshi Ninagawa, Hirokazu Yagi, Taiki Saito, Tokiro Ishikawa, Tetsushi Sakuma, Takashi Yamamoto, Koshi Imami, Yasushi Ishihama, Koichi Kato, Tetsuya Okada, Kazutoshi Mori
Publikováno v:
eLife, Vol 9 (2020)
Sequential mannose trimming of N-glycan (Man9GlcNAc2 -> Man8GlcNAc2 -> Man7GlcNAc2) facilitates endoplasmic reticulum-associated degradation of misfolded glycoproteins (gpERAD). Our gene knockout experiments in human HCT116 cells have revealed that E
Externí odkaz:
https://doaj.org/article/a6958c22d4d74c03ab92d18cccd4e08f
Autor:
Tomoaki Bessho, Tetsuya Okada, Chihiro Kimura, Takahiro Shinohara, Ai Tomiyama, Akira Imamura, Mitsuru Kuwamura, Kazuhiko Nishimura, Ko Fujimori, Satoshi Shuto, Osamu Ishibashi, Bruno Kilunga Kubata, Takashi Inui
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 10, Iss 1, p e0004339 (2016)
The metabolic pathway of purine nucleotides in parasitic protozoa is a potent drug target for treatment of parasitemia. Guanosine 5'-monophosphate reductase (GMPR), which catalyzes the deamination of guanosine 5'-monophosphate (GMP) to inosine 5'-mon
Externí odkaz:
https://doaj.org/article/8cd7383089a2418681963d410a9596ac
Autor:
Natalia J Martinez, Ganesha Rai, Adam Yasgar, Wendy A Lea, Hongmao Sun, Yuhong Wang, Diane K Luci, Shyh-Ming Yang, Kana Nishihara, Shunichi Takeda, Mohiuddin Sagor, Irina Earnshaw, Tetsuya Okada, Kazutoshi Mori, Kelli Wilson, Gregory J Riggins, Menghang Xia, Maurizio Grimaldi, Ajit Jadhav, David J Maloney, Anton Simeonov
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0161486 (2016)
The endoplasmic reticulum (ER) is involved in Ca2+ signaling and protein folding. ER Ca2+ depletion and accumulation of unfolded proteins activate the molecular chaperone GRP78 (glucose-regulated protein 78) which in turn triggers the ER stress respo
Externí odkaz:
https://doaj.org/article/32648e68d1c64d85b6cf13c0dd1ec1af
Autor:
Natalia J Martinez, Ganesha Rai, Adam Yasgar, Wendy A Lea, Hongmao Sun, Yuhong Wang, Diane K Luci, Shyh-Ming Yang, Kana Nishihara, Shunichi Takeda, Mohiuddin, Irina Earnshaw, Tetsuya Okada, Kazutoshi Mori, Kelli Wilson, Gregory J Riggins, Menghang Xia, Maurizio Grimaldi, Ajit Jadhav, David J Maloney, Anton Simeonov
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0166506 (2016)
[This corrects the article DOI: 10.1371/journal.pone.0161486.].
Externí odkaz:
https://doaj.org/article/e1507d1cbf0448b0bcd91c7fd014f013
Autor:
Byungseok Jin, Tokiro Ishikawa, Makoto Kashima, Rei Komura, Hiromi Hirata, Tetsuya Okada, Kazutoshi Mori
Publikováno v:
Life Science Alliance. 6(7)
The unfolded protein response is triggered in vertebrates by ubiquitously expressed IRE1α/β (although IRE1β is gut-specific in mice), PERK, and ATF6α/β, transmembrane-type sensor proteins in the ER, to cope with ER stress, the accumulation of un