Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Tetsuya Kimoto"'
Autor:
Yoshimasa Komatsuzaki, Yusuke Hatanaka, Gen Murakami, Hideo Mukai, Yasushi Hojo, Minoru Saito, Tetsuya Kimoto, Suguru Kawato
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34124 (2012)
BACKGROUND: Modulation of dendritic spines under acute stress is attracting much attention. Exposure to acute stress induces corticosterone (CORT) secretion from the adrenal cortex, resulting in rapid increase of CORT levels in plasma and the hippoca
Externí odkaz:
https://doaj.org/article/00f7589eac8e4630bc1549d08ab49b39
Autor:
Shimpei Higo, Yasushi Hojo, Hirotaka Ishii, Yoshimasa Komatsuzaki, Yuuki Ooishi, Gen Murakami, Hideo Mukai, Takeshi Yamazaki, Daiichiro Nakahara, Anna Barron, Tetsuya Kimoto, Suguru Kawato
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e21631 (2011)
BACKGROUND: Brain synthesis of steroids including sex-steroids is attracting much attention. The endogenous synthesis of corticosteroids in the hippocampus, however, has been doubted because of the inability to detect deoxycorticosterone (DOC) syntha
Externí odkaz:
https://doaj.org/article/0e0ae85184234b9e8422ad0e1eb8df60
Autor:
Yasushi Hojo, Yoshimasa Komatsuzaki, Jonghyuk Kim, Tetsuya Kimoto, Hideo Mukai, Ayako Hiragushi, Muneki Ikeda, Suguru Kawato, Gen Murakami, Yusuke Hatanaka
Publikováno v:
Brain Research. 1621:121-132
Rapid modulation of hippocampal synaptic plasticity by locally synthesized androgen is important in addition to circulating androgen. Here, we investigated the rapid changes of dendritic spines in response to the elevation of dihydrotestosterone (DHT
Autor:
Yoshimasa Komatsuzaki, Gen Murakami, Hideo Mukai, Yusuke Hatanaka, Rei Sato, Yasushi Hojo, Suguru Kawato, Tetsuya Kimoto, Muneki Ikeda, Arisa Munetomo
Publikováno v:
Hormones and Behavior. 74:149-156
This article is part of a Special Issue “Estradiol and cognition”. Estradiol (E2) is locally synthesized within the hippocampus and the gonads. Rapid modulation of hippocampal synaptic plasticity by E2 is essential for synaptic regulation. The mo
Autor:
Gen Murakami, Yusuke Hatanaka, Yasushi Hojo, Tetsuya Kimoto, Yoshimasa Komatsuzaki, Suguru Kawato, Yuuki Ooishi, Hideo Mukai, Shimpei Higo, Mari Ogiue-Ikeda
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 131:37-51
The hippocampus synthesizes estrogen and androgen in addition to the circulating sex steroids. Synaptic modulation by hippocampus-derived estrogen or androgen is essential to maintain healthy memory processes. Rapid actions (1-2h) of 17β-estradiol (
Autor:
Yasuyuki Shimohigashi, Nobuaki Tanabe, Suguru Kawato, Yasushi Hojo, Tetsuya Kimoto, Hinako Yoshino, Mari Ogiue-Ikeda
Publikováno v:
Molecular and Cellular Endocrinology. 351:317-325
We demonstrated the rapid effects of 10nM bisphenol A (BPA) on the spinogenesis of adult rat hippocampal slices. The density of spines was analyzed by imaging Lucifer Yellow-injected CA1 neurons in slices. Not only the total spine density but also th
Autor:
Yusuke Hatanaka, Gen Murakami, Yoshimasa Komatsuzaki, Suguru Kawato, Yasushi Hojo, Rei Sato, Tetsuya Kimoto, Kenji Mitsuhashi, Hideo Mukai
Publikováno v:
Cerebral Cortex (New York, NY)
Accurate 3D determination of postsynaptic structures is essential to our understanding memory-related function and pathology in neurons. However, current methods of spine analysis require time-consuming and labor-intensive manual spine identification
Publikováno v:
Endocrinology. 151:5795-5806
Although sex steroids play a crucial role in the postnatal brain development, the age-related changes in the hippocampal steroidogenesis remain largely unknown. We performed comprehensive investigations for the mRNA expressions of 26 sex steroidogeni
Autor:
Gen Murakami, Hideo Mukai, Yusuke Hatanaka, Yasushi Hojo, Shimpei Higo, Tetsuya Kimoto, Suguru Kawato, Mari Ogiue-Ikeda
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1800:1030-1044
The hippocampus is a center for learning and memory as well as a target of Alzheimer's disease in aged humans. Synaptic modulation by estrogen is essential to understand the molecular mechanisms of estrogen replacement therapy. Because the local synt
Autor:
Yasushi Hojo, Kohei Nakajima, Tetsuya Kimoto, Donald Poirier, Hirotaka Ishii, Shimpei Higo, Toshihiro Kominami, Suguru Kawato
Publikováno v:
Biochemical and Biophysical Research Communications. 385:62-66
Sex-steroid synthesis in the hippocampus had been thought to be much more active at the neonatal stage than at the adult stage. However, the detailed comparison between these two stages had not been demonstrated yet. Here we performed the comparison