Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Tetsuya Handa"'
Autor:
Ioana Olan, Masami Ando-Kuri, Aled J. Parry, Tetsuya Handa, Stefan Schoenfelder, Peter Fraser, Yasuyuki Ohkawa, Hiroshi Kimura, Masako Narita, Masashi Narita
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract HMGA1 is an abundant non-histone chromatin protein that has been implicated in embryonic development, cancer, and cellular senescence, but its specific role remains elusive. Here, we combine functional genomics approaches with graph theory t
Externí odkaz:
https://doaj.org/article/7476e4a7107d49bfbd49a2a4b2b12352
Autor:
Kazumitsu Maehara, Kosuke Tomimatsu, Akihito Harada, Kaori Tanaka, Shoko Sato, Megumi Fukuoka, Seiji Okada, Tetsuya Handa, Hitoshi Kurumizaka, Noriko Saitoh, Hiroshi Kimura, Yasuyuki Ohkawa
Publikováno v:
Molecular Systems Biology, Vol 17, Iss 11, Pp 1-20 (2021)
Abstract Recent advances in genome‐wide technologies have enabled analyses using small cell numbers of even single cells. However, obtaining tissue epigenomes with cell‐type resolution from large organs and tissues still remains challenging, espe
Externí odkaz:
https://doaj.org/article/a14215197b00491ea6506a7f9089eef7
Autor:
Linda S. Forero-Quintero, William Raymond, Tetsuya Handa, Matthew N. Saxton, Tatsuya Morisaki, Hiroshi Kimura, Edouard Bertrand, Brian Munsky, Timothy J. Stasevich
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
During transcription, RNA polymerase II (RNAP2) is recruited to promoters and phosphorylated stepwise; so far, these steps have not been visualized in a single-copy gene in live cells. Here the authors use single-molecule microscopy to visualize endo
Externí odkaz:
https://doaj.org/article/9ac9a177c745472c9f09664f8916d4d9
Autor:
Sanki Tashiro, Tetsuya Handa, Atsushi Matsuda, Takuto Ban, Toru Takigawa, Kazumi Miyasato, Kojiro Ishii, Kazuto Kugou, Kunihiro Ohta, Yasushi Hiraoka, Hisao Masukata, Junko Kanoh
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
A chromosome is composed of structurally and functionally distinct domains. Here, Tashiro et al. report that the conserved centromeric protein Sgo2 localizes at the subtelomeres preferentially during G2phase and is essential for the formation of a hi
Externí odkaz:
https://doaj.org/article/fe18f516242748168003ebe110edff16
Autor:
Taiga Yamazaki, Yu Hatano, Tetsuya Handa, Sakiko Kato, Kensuke Hoida, Rui Yamamura, Takashi Fukuyama, Takayuki Uematsu, Noritada Kobayashi, Hiroshi Kimura, Kazuo Yamagata
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0177764 (2017)
To study the impact of epigenetic changes on biological functions, the ability to manipulate the epigenetic status of certain genomic regions artificially could be an indispensable technology. "Epigenome editing" techniques have gradually emerged tha
Externí odkaz:
https://doaj.org/article/765933bdc6f64bfa81377cfa1af57250
Autor:
Hiroki Ozawa, Azusa Kambe, Kodai Hibi, Satoshi Murakami, Akira Oikawa, Tetsuya Handa, Katsunori Fujiki, Ryuichiro Nakato, Katsuhiko Shirahige, Hiroshi Kimura, Nobuaki Shiraki, Shoen Kume
Publikováno v:
Stem cells (Dayton, Ohio).
Human induced pluripotent stem cells (iPSCs) require high levels of methionine (Met). Met deprivation results in a rapid decrease in intracellular S-adenosyl-methionine (SAM), poising human iPSCs for differentiation and leading to the apoptosis of un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e331794bb2343896bd03766bb9f07b3
https://pubmed.ncbi.nlm.nih.gov/36472570
https://pubmed.ncbi.nlm.nih.gov/36472570
Autor:
Yuko Sato, Makio Tokunaga, Tetsuya Handa, Satoshi Uchino, Yasuyuki Ohkawa, Yuma Ito, Hiroshi Kimura
Publikováno v:
The Journal of Cell Biology
Uchino et al. have developed a genetically encoded probe to specifically detect the Ser2-phosphorylated, elongating form of RNA polymerase II in living cells. Ser2-phosphorylated RNA polymerase foci exhibit more dynamic motion than chromatin replicat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c945d0b57dd97faebd1830d7038f5f6
http://europepmc.org/articles/PMC8647360
http://europepmc.org/articles/PMC8647360
Autor:
David M. Gilbert, Vishnu Dileep, Tetsuya Handa, Daniel A. Bartlett, Hiroshi Kimura, Steven Henikoff, Yasuyuki Ohkawa
Publikováno v:
Journal of Cell Biology. 220
Chromatin profiling in single cells has been extremely challenging and almost exclusively limited to histone proteins. In cases where single-cell methods have shown promise, many require highly specialized equipment or cell type–specific protocols
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2c0a116bf29eb514938400228369a24
https://doi.org/10.1083/jcb.202103078
https://doi.org/10.1083/jcb.202103078
Autor:
Megumi Fukuoka, Noriko Saitoh, Kosuke Tomimatsu, Yasuyuki Ohkawa, Shoko Sato, Hitoshi Kurumizaka, Kazumitsu Maehara, Tetsuya Handa, Hiroshi Kimura, Akihito Harada, Seiji Okada, Kaori Tanaka
Publikováno v:
Molecular Systems Biology, Vol 17, Iss 11, Pp n/a-n/a (2021)
Molecular Systems Biology
Molecular Systems Biology
Recent advances in genome‐wide technologies have enabled analyses using small cell numbers of even single cells. However, obtaining tissue epigenomes with cell‐type resolution from large organs and tissues still remains challenging, especially wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6d3e5c8a822dea6284f1a4090833d4b
https://doaj.org/article/a14215197b00491ea6506a7f9089eef7
https://doaj.org/article/a14215197b00491ea6506a7f9089eef7
Autor:
Katsuhiko Shirahige, Kazumitsu Maehara, Yoko Hayashi-Takanaka, Yasuyuki Ohkawa, Jumpei Nogami, Akihito Harada, Hiroshi Kimura, Yasuhiro Arimura, Hitoshi Kurumizaka, Tetsuya Handa
Publikováno v:
Nature Cell Biology. 21:287-296
Chromatin plays a crucial role in gene regulation, and chromatin immunoprecipitation followed by sequencing (ChIP–seq) has been the standard technique for examining protein–DNA interactions across the whole genome. However, it is difficult to obt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d87465b4b893f899d7b4894dc3730bf9
https://doi.org/10.1038/s41556-018-0248-3
https://doi.org/10.1038/s41556-018-0248-3