Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Tetsuya Hagio"'
Autor:
Masaru Sakai, Tetsuya Hagio, Tetsuya Yasuhiro, Sho Kouyama, Hidenori Miyata, Yasuo Yonetomi, Shinya Sakimoto, Takehiro Ono, Seishi Katsumata, Takashi Sasamura
Publikováno v:
Stroke. 50
Introduction: Factor XI (FXI) is an important component in the intrinsic pathway of the coagulation system. FXI antisense oligonucleotide achieves antithrombotic efficacy with a low risk of bleeding in preclinical and early clinical studies. ONO-8610
Autor:
Masashi Gohda, Kenji Tanaka, Hiromu Habashita, Sho Koyama, Tetsuya Hagio, Kazuhito Kawabata, Akira Imagawa, Hidekazu Matsuya, Masaru Sakai, Yasushi Hirota, Yasuo Yonetomi, Taihei Nishiyama, Ai Hashimoto, Takehiro Ono, Shinya Sakimoto
Publikováno v:
Stroke. 48
Background and Purpose: High levels of blood coagulation factor XI (FXI) are an established risk factor for acute ischemic stroke and thrombosis. Patients with severe FXI deficiency have a low risk of ischemic stroke. In addition, FXI-deficient or an
Autor:
Naoki Hasegawa, Tetsuya Hagio, Akitoshi Ishizaka, Satoru Hashimoto, Katsuya Kishikawa, Kazuhito Kawabata, Sadatomo Tasaka
Publikováno v:
Pulmonary Pharmacology & Therapeutics. 21:884-891
Neutrophil elastase (NE) has been recognized as a double-edge sword as it can be both host-defensive and pro-inflammatory depending on its tissue level and microenvironment. The present study was designed to examine whether inhibition of NE activity
Publikováno v:
Brain Research. 528:231-237
The mechanisms of action of tachykinin peptides thought to be involved in central cardiovascular regulation were examined. Intracerebroventricular injections (i.c.v.) of tachykinin peptides caused dose-dependent increases in blood pressure and heart
Autor:
Tetsuya Hagio, Sho Koyama, Keizo Suzuki, Ai Hashimoto, Kenji Tanaka, Yasushi Hirota, Kazuhito Kawabata, Hidekazu Matsuya, Taihei Nishiyama, Masaru Sakai, Masashi Gohda, Takehiro Ono, Akira Imagawa, Takashi Kondo
Publikováno v:
Blood. 124:1542-1542
Introduction: Congenital human blood coagulation factor XI (FXI) deficiency is associated with bleeding that is less severe than that observed in patients with other coagulation factor deficiencies, whereas severe FXI deficiency confers the decreased
Publikováno v:
Pulmonary pharmacologytherapeutics. 18(4)
The in vivo contribution of neutrophil elastase (NE) in phorbol myristate acetate (PMA)-induced acute lung injury has so far been unclear. This study examined the role of NE in PMA-induced acute lung injury in conscious rabbits, using a specific NE i
Autor:
Tetsuya Hagio, Hiroyuki Ohno, Shintaro Nakao, Taira Abiru, Shigeru Matsumoto, Kazuhito Kawabata
Publikováno v:
European journal of pharmacology. 488(1-3)
This study examined whether the specific inhibition of neutrophil elastase by sivelestat sodium hydrate (sivelestat) reduced deaths associated with severe acute lung injury after hydrochloric acid (HCl) aspiration in hamsters. Animals that received a
Publikováno v:
Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 122(2)
Imbalance between neutrophil elastase (NE) and its endogenous protease inhibitors has been considered to be one of possible mechanisms by which NE causes lung tissue destruction. It has been shown that the amount and/or activity of NE is increased in
Publikováno v:
European journal of pharmacology. 451(1)
Beside its physiological function as a powerful host defense, neutrophil elastase is also known as one of the most destructive enzymes in the body. Current notion holds that neutrophil elastase is able to escape from regulation by multiple protease i
Inhibition of neutrophil elastase activity attenuates complement-mediated lung injury in the hamster
Autor:
Tetsuya Hagio, Hiroyuki Ohno, Shigeru Matsumoto, Hidekazu Matsuoka, Kazuhito Kawabata, Shintaro Nakao
Publikováno v:
European journal of pharmacology. 426(1-2)
The role of neutrophil elastase in complement-mediated lung injury was examined in hamsters using a specific neutrophil elastase inhibitor, sodium N-[2-[4-(2,2 dimethylpropionyloxy)phenylsulfonylamino]benzoyl]aminoacetate tetrahydrate (sivelestat). I