Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Tetsuya Gotoh"'
Autor:
Xianlin Zou, Dae Wook Kim, Tetsuya Gotoh, Jingjing Liu, Jae Kyoung Kim, Carla V. Finkielstein
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Circadian rhythms form a self-sustaining, endogenous, time-keeping system that allows organisms to anticipate daily environmental changes. The core of the clock network consists of interlocking transcriptional-translational feedback loops that ensure
Externí odkaz:
https://doaj.org/article/6f4c00e6e53b4021af4de388f2875528
Autor:
Carla V. Finkielstein, jingjing liu, John J. Tyson, Tetsuya Gotoh, Marian Vila-Caballer, Philip E. Stauffer, Jae Kyoung Kim
Publikováno v:
Proceedings of the National Academy of Sciences. 113:13516-13521
The circadian clock and cell cycle networks are interlocked on the molecular level, with the core clock loop exerting a multilevel regulatory role over cell cycle components. This is particularly relevant to the circadian factor Period 2 (Per2), whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f38e9a3eeb997561d6be880d83d3bb3
https://doi.org/10.1073/pnas.1607984113
https://doi.org/10.1073/pnas.1607984113
Autor:
Carla V. Finkielstein, Tetsuya Gotoh, Xianlin Zou, Jingjing Liu, Anne M. Brown, Liang Jiang, Jae Kyoung Kim, Esther L. Wisdom
Publikováno v:
Science Signaling. 11
The circadian clock relies on posttranslational modifications to set the timing for degradation of core regulatory components, which drives clock progression. Ubiquitin-modifying enzymes that target clock components for degradation mainly recognize p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20182b7fc1c4467ba452f8a6865cf11b
https://doi.org/10.1126/scisignal.aau0715
https://doi.org/10.1126/scisignal.aau0715
Autor:
Tetsuya Gotoh, Anne M. Brown, Carla V. Finkielstein, Jae Kyoung Kim, Liang Jiang, Xianlin Zou, Jingjing Liu
The circadian clock relies on post-translational modifications to set the timing for degradation of core regulatory components and, thus, sets clock progression. Ubiquitin-modifying enzymes targeting clock components for degradation are known to most
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d32c93fd764305580017e1ec90772e0a
Publikováno v:
postdoc journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f488cf1975e3667d13908b166acd473b
https://doi.org/10.14304/surya.jpr.v6n3.3
https://doi.org/10.14304/surya.jpr.v6n3.3
Publikováno v:
Developmental Biology. 310(2):341-347
In mammalian cells, E-type cyclins (E1 and E2) are generally believed to be required for entry into S phase. However, in mice, cyclin E is largely dispensable for normal embryogenesis. Moreover, Drosophila cyclin E plays a critical role in cell fate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f35be933dfec193a9640b84ebc5aadee
Publikováno v:
Software: Practice and Experience. 36:761-783
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca89e045a24d9d1c1b11cd6d407023e0
https://doi.org/10.1002/spe.716
https://doi.org/10.1002/spe.716
Publikováno v:
Molecular Biology of the Cell
Association of the circadian Per2 factor to p53 results in cytosol–nuclear shuttling of the complex and further association to Mdm2. The trimeric complex remains in the nucleus until a genotoxic signal frees p53, allowing for a transcriptional chec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19e452064b69b41992c98e8d65c5e8a1
https://pubmed.ncbi.nlm.nih.gov/25411341
https://pubmed.ncbi.nlm.nih.gov/25411341
Autor:
Carlo S. Santos, Jianhua Yang, Carla V. Finkielstein, Tetsuya Gotoh, jingjing liu, Marian Vila-Caballer
Publikováno v:
Molecular Biology of the Cell
Period 2 forms a trimeric complex with p53 and Mdm2. As a result, p53’s transcriptional activity and stability are modulated in unstressed cells, ensuring that basal levels are present if a p53-mediated response is needed. These data provide eviden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47de89930af080fdd130e1f7c89c0f46
https://pubmed.ncbi.nlm.nih.gov/25103245
https://pubmed.ncbi.nlm.nih.gov/25103245
Publikováno v:
Journal of Cell Science. 114:3397-3406
Checkpoint controls ensure chromosomal integrity through the cell cycle. Chk1 and Cds1/Chk2 are effector kinases in the G2-phase checkpoint activated by damaged or unreplicated DNA, and they prevent entry into M-phase through inhibition of cyclin B-C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afd6d9fd756cd75f696ce62360c00d4e
https://doi.org/10.1242/jcs.114.18.3397
https://doi.org/10.1242/jcs.114.18.3397