Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Tetsuya Fukazawa"'
Autor:
Rie Yatsunami, Toshiaki Fukui, Kimiko Endo, Satoshi Nakamura, Tokusuke Hayami, Tetsuya Fukazawa, Sumiko Masuda, Naoya Koizumi
Publikováno v:
Extremophiles. 10:251-255
Alkaliphilic Nocardiopsis sp. strain F96 produced three beta-1,3-glucanase isozymes of different molecular masses (BglF1, BglF2 and BglF3). The N-terminal amino acid sequences of BglFs indicated that these isozymes were the products of a single gene.
Autor:
Katsuyoshi Nakajima, Osamu Mukaiyama, Toshiyasu Takemoto, Yukiko Iio, Tetsuya Fukazawa, Koki Ishibashi, Yamaguchi Takeshi, Kazuhiro Itoh, Takahide Nishi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:1665-1668
We report herein the synthesis and stereochemical structure–activity relationships of novel morpholine analogues 12 and 13 with regards to NK1, NK2 and NK3 tachykinin receptor binding affinity. An essential requirement for more potent binding affin
Publikováno v:
Tetrahedron: Asymmetry. 9:3251-3262
We report herein an efficient and practical synthetic method for the preparation of enantiomerically pure 2-[(2R)-arylmorpholin-2-yl]ethanols 1a–d, key intermediates of tachykinin receptor antagonist. Sharpless catalytic asymmetric dihydroxylation
Publikováno v:
Tetrahedron: Asymmetry. 9:2567-2570
We report simple and efficient methods for the preparation of enantiomerically pure spiro[benzo[ c ]thiophene-1(3 H ),4′-piperidine]-(2 S )-oxide ( S )- 1 , a key intermediate for the synthesis of tachykinin receptor antagonist, by resolution and a
Autor:
Satoshi Nakamura, S. Shimizu, Rie Yatsunami, Tomoko Sunami, Tetsuya Fukazawa, Wataru Adachi, Yuri Sakihama, Mamie Suzuki, Akio Takénaka
Publikováno v:
Acta Crystallographica Section D Biological Crystallography. 60:2081-2083
Chitosanase from Bacillus sp. strain K17 (ChoK) belongs to glycoside hydrolase family 8 and exhibits subclass II specificity. The purified protein is structurally stable over a wide pH range (3-10), but is active in a much narrower pH range (4.5-7.5)
Autor:
Toshihiko Hashimoto, Tetsuya Fukazawa
Publikováno v:
Tetrahedron: Asymmetry. 4:2323-2326
Optically pure (R)-2-cycloalken-1-ols were synthesized via highly enantioselective lipase-catalyzed transesterification of 2-substituted cycloalkanols.
Autor:
Toshihiko Hashimoto, Tetsuya Fukazawa
Publikováno v:
ChemInform. 25
Optically pure (R)-2-cycloalken-1-ols were synthesized via highly enantioselective lipase-catalyzed transesterification of 2-substituted cycloalkanols.
Publikováno v:
ChemInform. 29
We report simple and efficient methods for the preparation of enantiomerically pure spiro[benzo[ c ]thiophene-1(3 H ),4′-piperidine]-(2 S )-oxide ( S )- 1 , a key intermediate for the synthesis of tachykinin receptor antagonist, by resolution and a
Publikováno v:
ChemInform. 30
We report herein an efficient and practical synthetic method for the preparation of enantiomerically pure 2-[(2R)-arylmorpholin-2-yl]ethanols 1a–d, key intermediates of tachykinin receptor antagonist. Sharpless catalytic asymmetric dihydroxylation
Autor:
Mamie Suzuki, Satoshi Nakamura, Wataru Adachi, S. Shimizu, Yuri Sakihama, Akio Takénaka, Tetsuya Fukazawa, Rie Yatsunami, Tomoko Sunami
Publikováno v:
Journal of molecular biology. 343(3)
Crystal structures of chitosanase from Bacillus sp. K17 (ChoK) have been determined at 1.5 A resolution in the active form and at 2.0 A resolution in the inactive form. This enzyme belongs to the family GH-8, out of 93 glycoside hydrolase families, a